I think of the misses as part of the Ron Dayne Syndrome. Dayne had great stats at Wisconsin but when you looked at the highlight films he was usually running through massive holes from great blocking. But stats and awards said he was "a lock" when he wasn't. Same for John Hicks - won the Lambert Trophy and was runner-up for Heisman so he must be a lock.
GMs and coaches who don't have strong insight into players like to rely on press and stats if the pick backfires. Pacheco didn't have great game stats but when he broke 4.4 during a great combine (27 reps on bench) he came with CYA bust insurance.
Guys like Flowers, Hernandez, Thomas, Evan Neal had all the great size and strength stats but they couldn't move well enough to deal with all the Marvel defenders running like WRs and all juiced-up (ex Pro Bowl Army OT said).