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COVID-19 Pandemic: Transmissions, Deaths, Treatments, Vaccines, Interventions and More...

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I thought you were saying we should be lifting restrictions by day 15 (about 7 days from now) which is what Trump would probably push to do based of today’s presser.

I think this week you’re going to see a lot of spikes in other areas of the country since it’s clearly been in the NY area for 3-4 weeks now and well before social distancing became a thing.

Isolating is gonna have to continue through the majority of April but agree at some point you have to loosen restrictions and let people start living, working and spending $. It sounds like a larger portion of the population may actually be asymptomatic which sucks you don’t know you have it or can pass it but also good because we could have a very large population who’ve built some immunity.


I could say that perhaps another 10-14 days after the 15 day period ends, at least half of the country goes back to somewhat normal as states take over monitoring....especially if the next week does not see a big spike in those areas, the numbers are currently low, i dont know how much testing is going on but some of those states added no new reported cases
 
In case not posted, yet, the WHO is launching a 4-pronged mega-trial now, which is great to hear...

Scientists have suggested dozens of existing compounds for testing, but WHO is focusing on what it says are the four most promising therapies: an experimental antiviral compound called remdesivir; the malaria medications chloroquine and hydroxychloroquine; a combination of two HIV drugs, lopinavir and ritonavir; and that same combination plus interferon-beta, an immune system messenger that can help cripple viruses. Some data on their use in COVID-19 patients have already emerged—the HIV combo failed in a small study in China—but WHO believes a large trial with a greater variety of patients is warranted.

Enrolling subjects in SOLIDARITY will be easy. When a person with a confirmed case of COVID-19 is deemed eligible, the physician can enter the patient’s data into a WHO website, including any underlying condition that could change the course of the disease, such as diabetes or HIV infection. The participant has to sign an informed consent form that is scanned and sent to WHO electronically. After the physician states which drugs are available at his or her hospital, the website will randomize the patient to one of the drugs available or to the local standard care for COVID-19.

“After that, no more measurements or documentation are required,” says Ana Maria Henao Restrepo, a medical officer at WHO’s Department of Immunization Vaccines and Biologicals. Physicians will record the day the patient left the hospital or died, the duration of the hospital stay, and whether the patient required oxygen or ventilation, she says. “That’s all.”

The design is not double-blind, the gold standard in medical research, so there could be placebo effects from patients knowing they received a candidate drug. But WHO says it had to balance scientific rigor against speed. The idea for SOLIDARITY came up less than 2 weeks ago, Henao Restrepo says, and the agency hopes to have supporting documentation and data management centers set up next week. “We are doing this in record time,” she says.




https://www.sciencemag.org/news/202...al-four-most-promising-coronavirus-treatments


That's great, but they are behind the eight ball. All these trials are already being conducted as of today ............

https://clinicaltrials.gov/ct2/resu...Search=Apply&recrs=a&age_v=&gndr=&type=&rslt=

Also, if you look for Kaletra, you will notice that there is no trial registered as a mono therapy, which suggests that scientist/MDs already knew it is not effective as a stand alone. The July trial results I referenced in my past post is in combination with ribavibrin and an interferon beta 1B. The "anecdotal" results from various sources were using this cocktail.

https://clinicaltrials.gov/ct2/show/NCT04276688?recrs=a&cond=coronavirus&draw=2&rank=12


When this is all said and done - it isn't WHO who will save the day. It will be the "evil" drug companies.
 
After reading this article from the Washington Post about how the CDC fumbled creating a proper test to mass produce all the while you had a company in Germany and the WHO could have help the US efforts in January to mass produce and ship quality test kits throughout the US by early Feb is fracking infuriating to read.

“Founder of a small Berlin-based company, the ponytailed 54-year-old first raced to help German researchers come up with a diagnostic test and then spurred his company to produce and ship more than 1.4 million tests by the end of February for the World Health Organization.

“My wife and I have been working 16 hours a day, seven days a week, ever since,” Landt said by phone about 1 a.m. Friday, Berlin time. “Our days are full.”

By contrast, over the same critical period, U.S. efforts to distribute tests ground nearly to a halt, and the country’s inability to produce them left public health

The United States’ struggles, in Landt’s view, stemmed from the fact the country took too long to use private companies to develop the tests. The coronavirus pandemic was too big and moving too fast for the CDC to develop its own tests in time, he said.

“There are 10 companies in the U.S. who could have developed the tests for them,” Landt said. “Commercial companies will run to an opportunity like this.”

Sign up for our Coronavirus Updates newsletter to track the outbreak. All stories linked in the newsletter are free to access.

As the coronavirus continues to spread across the United States, causing more than 80 deaths and over 4,000 confirmed cases, the struggles that overwhelmed the nation’s testing are becoming clearer.

First, the CDC moved too slowly to tap into the expertise of academia and private companies such as Landt’s, experts said. For example, it wasn’t until last week that large companies such as Roche and Thermo Fisher won approval from the Food and Drug Administration to produce their own tests.


As early as Feb. 6, four weeks after the genome of the virus was published, the WHO had shipped 250,000 diagnostic tests to 70 laboratories around the world, the agency said.

By comparison, the CDC at that time was shipping about 160,000 tests to labs across the nation — but then the manufacturing troubles were discovered, and most would be deemed unusable because they produced confusing results. Over the next three weeks, only about 200 of those tests sent to labs would be used, according to CDC statistics.


In fact, the U.S. efforts to distribute a working test stalled until Feb. 28, when federal officials revised the CDC test and began loosening up FDA rules that had limited who could develop coronavirus diagnostic tests.

In the absence of tests, the calls for the United States to tap into the expertise of academia, hospitals and private companies, such as Landt’s, grew more insistent.

“It took [the CDC] awhile to come up with the test, honestly,” said Alex Greninger of the University of Washington.

His lab had developed its own test and began seeking approval to use it on patients on Feb. 18. But that test, along with others that had been developed in various academic centers and hospitals, could not be used on patients until the FDA relaxed its testing rules on Feb 29.

He noted that many of the state public health labs had also figured out how to use the CDC test properly — by tossing one of its components — but were not allowed to actually do so until the FDA approved the workaround that same day.


“We had all these state public health labs that had a perfectly good [test] on their hands, and they knew it, they were upset,” Greninger said.

“What surprised me the most was to hear how much emphasis there is at CDC on quality control — to the point where, in my opinion, it really compromised surveillance,” said Michelle Mello, a professor of law and medicine and Stanford who recently wrote a paper about the delays in testing for coronavirus in the United States. “You can’t track what you don’t see.”

On March 7, FDA Commissioner Stephen M. Hahn stressed the importance of quality, noting that diagnostic tests in some other countries have been flawed. He did not specify which countries he meant, but China’s test may have produced lots of false positives, according to a recent publication by Chinese researchers.


“What’s important here is that we have a test that the American people can trust,” Hahn said.

But even a small firm, like Landt’s, is capable of producing a lot of high-quality tests and could have helped the efforts in the U.S., Landt said. His company, known as TIB for TIB Molbiol Syntheselabor GmbH, based their tests on the methods the German researchers published in January.

Though it has just 55 employees globally, TIB had experience in developing tests for SARS and the swine flu. It began producing the coronavirus tests in mid-January, just days after the Chinese researchers posted the virus’s genome, Landt said. It can produce about a million of them a week.”


Why did the CDC F up early test kits and not consult outside firms to help when the work product was solid in other countries and not only that the intellectual capital was available throughout the US at many companies to develop, produce and distribute quality test kits but we’re not asked? Something doesn’t smell right.



https://www.google.com/amp/s/www.washingtonpost.com/business/2020/03/16/cdc-who-coronavirus-tests/?outputType=amp
 
After reading this article from the Washington Post about how the CDC fumbled creating a proper test to mass produce all the while you had a company in Germany and the WHO could have help the US efforts in January to mass produce and ship quality test kits throughout the US by early Feb is fracking infuriating to read.

“Founder of a small Berlin-based company, the ponytailed 54-year-old first raced to help German researchers come up with a diagnostic test and then spurred his company to produce and ship more than 1.4 million tests by the end of February for the World Health Organization.

“My wife and I have been working 16 hours a day, seven days a week, ever since,” Landt said by phone about 1 a.m. Friday, Berlin time. “Our days are full.”

By contrast, over the same critical period, U.S. efforts to distribute tests ground nearly to a halt, and the country’s inability to produce them left public health

The United States’ struggles, in Landt’s view, stemmed from the fact the country took too long to use private companies to develop the tests. The coronavirus pandemic was too big and moving too fast for the CDC to develop its own tests in time, he said.

“There are 10 companies in the U.S. who could have developed the tests for them,” Landt said. “Commercial companies will run to an opportunity like this.”

Sign up for our Coronavirus Updates newsletter to track the outbreak. All stories linked in the newsletter are free to access.

As the coronavirus continues to spread across the United States, causing more than 80 deaths and over 4,000 confirmed cases, the struggles that overwhelmed the nation’s testing are becoming clearer.

First, the CDC moved too slowly to tap into the expertise of academia and private companies such as Landt’s, experts said. For example, it wasn’t until last week that large companies such as Roche and Thermo Fisher won approval from the Food and Drug Administration to produce their own tests.


As early as Feb. 6, four weeks after the genome of the virus was published, the WHO had shipped 250,000 diagnostic tests to 70 laboratories around the world, the agency said.

By comparison, the CDC at that time was shipping about 160,000 tests to labs across the nation — but then the manufacturing troubles were discovered, and most would be deemed unusable because they produced confusing results. Over the next three weeks, only about 200 of those tests sent to labs would be used, according to CDC statistics.


In fact, the U.S. efforts to distribute a working test stalled until Feb. 28, when federal officials revised the CDC test and began loosening up FDA rules that had limited who could develop coronavirus diagnostic tests.

In the absence of tests, the calls for the United States to tap into the expertise of academia, hospitals and private companies, such as Landt’s, grew more insistent.

“It took [the CDC] awhile to come up with the test, honestly,” said Alex Greninger of the University of Washington.

His lab had developed its own test and began seeking approval to use it on patients on Feb. 18. But that test, along with others that had been developed in various academic centers and hospitals, could not be used on patients until the FDA relaxed its testing rules on Feb 29.

He noted that many of the state public health labs had also figured out how to use the CDC test properly — by tossing one of its components — but were not allowed to actually do so until the FDA approved the workaround that same day.


“We had all these state public health labs that had a perfectly good [test] on their hands, and they knew it, they were upset,” Greninger said.

“What surprised me the most was to hear how much emphasis there is at CDC on quality control — to the point where, in my opinion, it really compromised surveillance,” said Michelle Mello, a professor of law and medicine and Stanford who recently wrote a paper about the delays in testing for coronavirus in the United States. “You can’t track what you don’t see.”

On March 7, FDA Commissioner Stephen M. Hahn stressed the importance of quality, noting that diagnostic tests in some other countries have been flawed. He did not specify which countries he meant, but China’s test may have produced lots of false positives, according to a recent publication by Chinese researchers.


“What’s important here is that we have a test that the American people can trust,” Hahn said.

But even a small firm, like Landt’s, is capable of producing a lot of high-quality tests and could have helped the efforts in the U.S., Landt said. His company, known as TIB for TIB Molbiol Syntheselabor GmbH, based their tests on the methods the German researchers published in January.

Though it has just 55 employees globally, TIB had experience in developing tests for SARS and the swine flu. It began producing the coronavirus tests in mid-January, just days after the Chinese researchers posted the virus’s genome, Landt said. It can produce about a million of them a week.”


Why did the CDC F up early test kits and not consult outside firms to help when the work product was solid in other countries and not only that the intellectual capital was available throughout the US at many companies to develop, produce and distribute quality test kits but we’re not asked? Something doesn’t smell right.



https://www.google.com/amp/s/www.washingtonpost.com/business/2020/03/16/cdc-who-coronavirus-tests/?outputType=amp

It is the biggest failure, to date, of the CDC and the administration. I've posted about this issue many times since about mid-February and it's been like watching a train wreck in slow motion with no ability to change the outcome. Testing early on during an outbreak, in particular, is the most important tool in the infectious disease toolkit (after figuring out what the infectious agent is, of course) and it was botched beyond belief.

There was no way to "stop" the outbreak since 300K Chinese came to the US before the travel ban, which slowed progression down in the US, but there's zero reason why the most advanced country on the planet couldn't have had unlimited working tests available from day one, like South Korea did (SK and the US had first patients on the same day) and had an outcome like theirs or Taiwan's. Single sourcing of the most important diagnostic tool was a colossal blunder, especially when there was a readily available test that was working just fine (and false positives don't matter with CV2, only false negatives do).

But no, we're about to become Italy, instead, at least with cases (unclear on deaths, as we're much lower now, but earlier in the outbreak) and we now can't figure out a way to get ventilators and masks (and increased hospital beds/ICU beds) to states that need them, meaning people will die unnecessarily within the next week or two as this outbreak likely continues to accelerate and overwhelms the health care system in NYC and probably other locations. I honestly can't believe the Federal Government might sit idly by and watch that happen.

Gov Cuomo isn't making these numbers up and they really haven't been that hard to see coming. I'm just a guy on a message board and I predicted 8 days in advance when we'd hit 5000 cases and we did and I predicted on Saturday that we'd hit 80,000 cases by this Wednesday and unfortunately, we're on our way to that and a far higher number beyond that eventually, especially if POTUS is actually thinking of backing off on social distancing and containment policies after the 15 Day period which ends next Monday.

That would be one of the dumbest moves in the history of this country, with an accelerating outbreak, although thankfully, it's not really a decision that's his to make as the Governors of the hardest hit and next in line to be hardest hit states (which probably generate 75% of the business and tax revenues for this country) are having none of that with 13 or so states in various stages of lockdown. These states need more than a stimulus package (which will be greatly welcomed though) - they need leadership from the President, supporting the guidance of his best scientific advisors and working with the states to ensure they have what they need to support their health care systems, doctors, and patients. It shouldn't have to be this hard to rally around defeating this pandemic as one Nation, like every other country is doing.

We've been trying to keep this thread focused on the scientific/medical issues associated with COVID-19, but right now it's hard to not talk about how political issues will potentially impact the medical outcomes, perhaps devastatingly.

@DJ Spanky - if you think this is too political, I'll move this post to the CE board, as I'd rather do that than have this thread become a pissing contest - let me know.
 
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you dont know that, you dont know the infomation they have or what they have learned

the other option is shutting down the country for 6 months more


they may be basing this that people are not flooding the emergency rooms across the country...if people are not sick then what we may be finding out is there are alot of people having coronavirus without any symptoms or getting sick at all. You or I have no idea what information they have about testing. Birx said 92% of cases across the country are negative. If they open in say 2 weeks in parts of the country, these will be areas where simply there are no coronavirus cases going on.

Look people are going to die..as Trump said 50K from the flu, people die of car accidents everyday, Unfortunately at some point we need to plow through, isolate the senior citizens and concentrate on eradicating from the hotspots

Almost every state has an accelerating outbreak, which is likely underestimated due to lack of testing and yes we know there's lack of testing, because when NY State has run over 25% of the tests in the country and WA has another 10%, it's pretty easy to say that the other states aren't doing the amount of testing per capita that they should be doing.

Also, what makes you think there will magically be decreases or even no cases in some states in 2 weeks, especially if everything just opens up? The virus is highly contagious and most of our states have >0.01% of their people infected. I'm just about certain that the 70% total infection rate number is way too high, but the Diamond Princess showed at least 20% is possible, albeit in a fairly confined space, but to not think most locations won't reach at least 1% infected without interventions is just kooky talk.
 
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there are likely thousands who have it who will never be tested and if they are staying in and not getting they are not giving it to anyone,remember we still have at least a week to go, I bet it goes another week after that. If people were staying in then that would have been 3 weeks of social distancing.
This is another major problem with the CDC guidance. Telling people to "stay at home" is ok if that person lives alone, but nobody who thinks they might have CV2 should be quarantining at home with other family members, as that's a sure fire way to spread the virus - in China 75-80% of transmissions were within households. In China and South Korea and other countries that have mostly contained the virus, suspected positive and actual positive cases were put in quarantine with other people in the same boat, where they could be monitored and treated and/or moved to the hospital if their symptoms became worse. That is how one stops the spread. And not testing everyone with symptoms is simply nuts - in outbreaks the first rule is to capture as much data as humanly possible.
 
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Birx talked on how each area of the country is following their own curve.....Washington is starting to get a handle on things....they are at least two weeks ahead of NYC right now., Each part of the country is facing a different situation. I think we get two weeks of extension after the first 15 day period, that is a full month, alot of data in at that time, no NYC and NJ will still be under severe restriction but Iowa and Idaho will not nor should they

Washington is not "getting a handle on things" at all, as their case rate continues to climb, albeit not as quickly as NY or NJ. I'm sure you mean well with your flurry of posts on this thread today, but please try to verify your facts before posting inaccurate things, as I've had to correct several of your posts.

Also, what makes you think that not having a national approach to this epidemic, led by the Feds instead of the governors, is the way to go? That doesn't mean every state is identical, but it does mean one body directing and coordinating many of the key activities across the states for consistency and to improve support. Every other country has done it that way.

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That's great, but they are behind the eight ball. All these trials are already being conducted as of today ............

https://clinicaltrials.gov/ct2/resu...Search=Apply&recrs=a&age_v=&gndr=&type=&rslt=

Also, if you look for Kaletra, you will notice that there is no trial registered as a mono therapy, which suggests that scientist/MDs already knew it is not effective as a stand alone. The July trial results I referenced in my past post is in combination with ribavibrin and an interferon beta 1B. The "anecdotal" results from various sources were using this cocktail.

https://clinicaltrials.gov/ct2/show/NCT04276688?recrs=a&cond=coronavirus&draw=2&rank=12


When this is all said and done - it isn't WHO who will save the day. It will be the "evil" drug companies.

Agreed and very aware of ongoing trials, but the WHO design is somewhat novel being open label in an emergency situation - it's possible they'll get a lot more data that way. And either way, the more trials the better. My guess is the Regeneron antibody therapy platform, which worked very well as an Ebola treatment (which others are also working on) will be the best approach for treatment (and maybe medium term prevention), but won't be ready until summer - which is why I'm praying for seasonality and a transmission slowdown by maybe mid/late April. Would be really nice to have somewhat of a break and then a clinical hit before a return of the virus next fall - if it is seasonal, like flu.
 
I've been checking the international and US by state stats on the number of cases every day for the past two weeks. This week, NJ was in fourth place after NY, WA, and CA. Then yesterday NJ edged past CA into 3rd place. An hour ago, I saw that NJ is now at about 2850 cases, just over doubling the CA total.

I'm in Arizona so am not aware of what might have spiked this huge jump all of a sudden. And I haven't seen anything the geographical distribution of NJ's cases. Is it due to a huge jump in the number of tests being administered?

I'm from NJ, not AZ, and still have family there, including a cousin who would be classified as very vulnerable, which is why I'm so concerned.

I appreciate any insights anyone might provide about this.

thank you.
Yes, it's due to testing. NJ likely has at least 20,000 positive cases right now, as the rule of thumb is 10X in a grossly undertested area - people didn't believe me when I said that about NY about 5 days ago likely having 20,000+ cases when they had ~2000 positives - most of the new positives are not from new transmissions, but from testing more.

The biggest piece of advice I can give anyone is to simply assume that everybody you see outside of your home (and maybe even inside if you don't know their contact history) has the virus and keep 6 feet away. That's even more important than hand washing, as person-to-person transmission is responsible for the vast majority of infections. It's also why it's borderline negligent that we don't have surgical masks for every citizen, like they do in the Asian countries that have largely controlled their outbreaks - they're very effective in keeping the germs in (i.e., trapping the virus laden droplets from infected people, even those who don't know they're infected).
 
Virus lived up to 17 days on the cruise ship after passengers both symptomatic and asymptomatic left. Just around half the positive cases on the cruise ship were asymptomatic at the time of testing. Not sure if it was still active that far along though.

From the article:

The virus “was identified on a variety of surfaces in cabins of both symptomatic and asymptomatic infected passengers up to 17 days after cabins were vacated on the Diamond Princess but before disinfection procedures had been conducted,” the researchers wrote, adding that the finding doesn’t necessarily mean the virus spread by surface.

The new study set out to determine how “transmission occurred across multiple voyages of several ships.” They noted that as of March 17, there were at least 25 cruise ship voyages with confirmed COVID-19 cases that were detected either during or after the cruise ended.

Almost half, 46.5%, of the infections aboard the Diamond Princess were asymptomatic when they were tested, partially explaining the “high attack rate” of the virus among passengers and crew.

https://www.cnbc.com/2020/03/23/cdc...bins-up-to-17-days-after-passengers-left.html

Was discussing this on Reddit and my guess is that the observation that there were virus RNA particles found 17 days after the passengers disembarked means that transmission from those particles is likely near nil, since the ship quarantine didn't go into effect until day 14 and almost 20% were infected, which means the vast majority of the ship likely contained virus particles and if they were truly capable of transmission, it's hard to believe that there wouldn't be more than 19% who tested positive. Most experts estimate that 95+% of transmission is person-to-person, not surface to person. This is also why we need to see antibody testing of the 81% of the passengers who tested negative for the virus (maybe many of them were exposed and developed antibodies, but didn't have viral loads high enough to be detected).
 
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It is the biggest failure, to date, of the CDC and the administration. I've posted about this issue many times since about mid-February and it's been like watching a train wreck in slow motion with no ability to change the outcome. Testing early on during an outbreak, in particular, is the most important tool in the infectious disease toolkit (after figuring out what the infectious agent is, of course) and it was botched beyond belief.

There was no way to "stop" the outbreak since 300K Chinese came to the US before the travel ban, which slowed progression down in the US, but there's zero reason why the most advanced country on the planet couldn't have had unlimited working tests available from day one, like South Korea did (SK and the US had first patients on the same day) and had an outcome like theirs or Taiwan's. Single sourcing of the most important diagnostic tool was a colossal blunder, especially when there was a readily available test that was working just fine (and false positives don't matter with CV2, only false negatives do).

But no, we're about to become Italy, instead, at least with cases (unclear on deaths, as we're much lower now, but earlier in the outbreak) and we now can't figure out a way to get ventilators and masks (and increased hospital beds/ICU beds) to states that need them, meaning people will die unnecessarily within the next week or two as this outbreak likely continues to accelerate and overwhelms the health care system in NYC and probably other locations. I honestly can't believe the Federal Government might sit idly by and watch that happen.

Gov Cuomo isn't making these numbers up and they really haven't been that hard to see coming. I'm just a guy on a message board and I predicted 8 days in advance when we'd hit 5000 cases and we did and I predicted on Saturday that we'd hit 80,000 cases by this Wednesday and unfortunately, we're on our way to that and a far higher number beyond that eventually, especially if POTUS is actually thinking of backing off on social distancing and containment policies after the 15 Day period which ends next Monday.

That would be one of the dumbest moves in the history of this country, with an accelerating outbreak, although thankfully, it's not really a decision that's his to make as the Governors of the hardest hit and next in line to be hardest hit states (which probably generate 75% of the business and tax revenues for this country) are having none of that with 13 or so states in various stages of lockdown. These states need more than a stimulus package (which will be greatly welcomed though) - they need leadership from the President, supporting the guidance of his best scientific advisors and working with the states to ensure they have what they need to support their health care systems, doctors, and patients. It shouldn't have to be this hard to rally around defeating this pandemic as one Nation, like every other country is doing.

We've been trying to keep this thread focused on the scientific/medical issues associated with COVID-19, but right now it's hard to not talk about how political issues will potentially impact the medical outcomes, perhaps devastatingly.

@DJ Spanky - if you think this is too political, I'll move this post to the CE board, as I'd rather do that than have this thread become a pissing contest - let me know.

You stated that "I honestly can't believe the Federal Government might sit idly by and watch that happen." In reference to NYC, sorry in advance if I m miss reading your meanining, but FEMA is building and staffing a 1000 person hospital in the Javits center, the Army Corp of Engineers has scouted multiple sites for more temporary hospitals, that Cuomo said he gave the go ahead to start building on Monday. 400 ventilators 500000 masks were shipped to NYC.
 
You stated that "I honestly can't believe the Federal Government might sit idly by and watch that happen." In reference to NYC, sorry in advance if I m miss reading your meanining, but FEMA is building and staffing a 1000 person hospital in the Javits center, the Army Corp of Engineers has scouted multiple sites for more temporary hospitals, that Cuomo said he gave the go ahead to start building on Monday. 400 ventilators 500000 masks were shipped to NYC.

New York has stated that they will need 30,000 ventilators not 500. Only the federal government has the ability to procure that many. They will also need to create 25,000 ICU beds.

The governor, health officials, hospitals, doctors, nurses, etc. have all stated that people will die unless they can get the thousands of ventilators needed and have been begging for help. So far the administrations response has been to send a fraction of what is needed and state that automakers will produce the ventilators.

Meanwhile, the automakers (as of today) are still conducting their feasibility study to determine if they can.

We are all hoping this works out, but the administrations response at this point in time has not been adequate. And it will become obvious to everyone, if bodies begin to pile up. Let’s hope that doesn’t happen, but there should be hell to pay if it does.
 
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New York has stated that they will need 30,000 ventilators not 500. Only the federal government has the ability to procure that many. They will also need to create 25,000 ICU beds.

The governor, health officials, hospitals, doctors, nurses, etc. have all stated that people will die unless they can get the thousands of ventilators needed and have been begging for help. So far the administrations response has been to send a fraction of what is needed and state that automakers will produce the ventilators.

Meanwhile, the automakers (as of today) are still conducting their feasibility study to determine if they can.

We are all hoping this works out, but the administrations response at this point in time has not been adequate. And it will become obvious to everyone, if bodies begin to pile up. Let’s hope that doesn’t happen, but there should be hell to pay if it does.

Exactly and NY has 5000 ventilators vs. the 30,000 needed and 53K beds vs. the 110K needed and 3K ICU beds vs. 18-37K needed and NY's projection is that they'll need these numbers in about 2-3 weeks given the coming tidal wave of cases and hospitalizations. He did not say when the State would run out of their current supplies, but presumably in <2 weeks. I had summarized Cuomo's presser, live, yesterday, with the numbers above (first link). And if US manufacturers can't come through, perhaps the Chinese can, as per the 2nd link. At this point, I'm sure New Yorkers don't really care where the supplies come from.

https://rutgers.forums.rivals.com/t...social-distancing.191275/page-28#post-4465651

https://www.straitstimes.com/busine...na-work-247-to-build-ventilators-for-italy-us
 
New York has stated that they will need 30,000 ventilators not 500. Only the federal government has the ability to procure that many. They will also need to create 25,000 ICU beds.

The governor, health officials, hospitals, doctors, nurses, etc. have all stated that people will die unless they can get the thousands of ventilators needed and have been begging for help. So far the administrations response has been to send a fraction of what is needed and state that automakers will produce the ventilators.

Meanwhile, the automakers (as of today) are still conducting their feasibility study to determine if they can.

We are all hoping this works out, but the administrations response at this point in time has not been adequate. And it will become obvious to everyone, if bodies begin to pile up. Let’s hope that doesn’t happen, but there should be hell to pay if it does.

Do you believe that the Federal Government is sitting on a supply of 100,000 ventilators and not supplying them? They cannot conjure up ventilators and retooling lines and producing items takes time.

GM is beyond the fesibility study:

General Motors is partnering up with Seattle-area medical equipment manufacturer Ventech Life Systems on what it’s calling Project V.

Working together, GM and Ventec want to rapidly scale up production of ventilators.

The plan has GM converting its parts plant in Kokomo, Indiana, to assemble the components necessary for ventilators. The goal of the venture is to build up to 200,000 ventilators, people familiar with the plans who asked not to be identified told Reuters.

As part of the effort to boost ventilator output from Ventec, GM has arranged for the supply of 95% of the parts needed to build the ventilator and is seeking to source the remaining 37 necessary parts, according to an email to suppliers from Shilpan Amin, GM’s vice president of global purchasing.

Ventec and GM have been working around the clock to develop the plans to build more ventilators. With GM on board to help, Ventec “is now planning exponentially higher ventilator production as fast as possible,” GM spokesperson Dan Flores told Reuters, adding that the Kokomo plant is the site being targeted to handle the production.

GM suppliers have jumped into action, working to convert their facilities from auto parts to ventilators parts. Additionally, some of Ventech’s suppliers are taking the steps necessary to exponentially grow their production rates to meet the expected demand.
 
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Agreed and very aware of ongoing trials, but the WHO design is somewhat novel being open label in an emergency situation - it's possible they'll get a lot more data that way. And either way, the more trials the better. My guess is the Regeneron antibody therapy platform, which worked very well as an Ebola treatment (which others are also working on) will be the best approach for treatment (and maybe medium term prevention), but won't be ready until summer - which is why I'm praying for seasonality and a transmission slowdown by maybe mid/late April. Would be really nice to have somewhat of a break and then a clinical hit before a return of the virus next fall - if it is seasonal, like flu.

This is the company I have my money on to come out with an effective vaccine against covid2.

https://techcrunch.com/2020/03/23/m...cine-available-to-healthcare-workers-by-fall/

https://www.modernatx.com/modernas-work-potential-vaccine-against-covid-19

Their success rate for other vaccine trials that they have conducted using their unique technology (using mRNA rather than a small sample of the virus being injected into humans) has been 100% effective.

Stay vigilant and survive this year and by next year covid2 will go the way of the Dodo and we can go back to talking about how Schiano is doing.
 
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Do you believe that the Federal Government is sitting on a supply of 100,000 ventilators and not supplying them? They cannot conjure up ventilators and retooling lines and producing items takes time.

GM is beyond the fesibility study:

General Motors is partnering up with Seattle-area medical equipment manufacturer Ventech Life Systems on what it’s calling Project V.

Working together, GM and Ventec want to rapidly scale up production of ventilators.

The plan has GM converting its parts plant in Kokomo, Indiana, to assemble the components necessary for ventilators. The goal of the venture is to build up to 200,000 ventilators, people familiar with the plans who asked not to be identified told Reuters.

As part of the effort to boost ventilator output from Ventec, GM has arranged for the supply of 95% of the parts needed to build the ventilator and is seeking to source the remaining 37 necessary parts, according to an email to suppliers from Shilpan Amin, GM’s vice president of global purchasing.

Ventec and GM have been working around the clock to develop the plans to build more ventilators. With GM on board to help, Ventec “is now planning exponentially higher ventilator production as fast as possible,” GM spokesperson Dan Flores told Reuters, adding that the Kokomo plant is the site being targeted to handle the production.

GM suppliers have jumped into action, working to convert their facilities from auto parts to ventilators parts. Additionally, some of Ventech’s suppliers are taking the steps necessary to exponentially grow their production rates to meet the expected demand.


The federal government is sitting on a supply of at least 10,000 which they have stated is in their stockpile. So yes they are sitting on it.

I understand they are holding them back because other parts may need them too.

But what they can do is order manufacturers that already make them or others who have similar manufacturing processes to churn them out 24/7. Send those manufacturers any support they need (supplies, workforce, anything). I have not heard that this has been done to a large scale at this point in time.

If the federal government is relying on GM to solve it’s problems, they should release the ventilators from the stockpile and then restock once GM has them produced.
 
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Do you believe that the Federal Government is sitting on a supply of 100,000 ventilators and not supplying them? They cannot conjure up ventilators and retooling lines and producing items takes time.

GM is beyond the fesibility study:

General Motors is partnering up with Seattle-area medical equipment manufacturer Ventech Life Systems on what it’s calling Project V.

Working together, GM and Ventec want to rapidly scale up production of ventilators.

The plan has GM converting its parts plant in Kokomo, Indiana, to assemble the components necessary for ventilators. The goal of the venture is to build up to 200,000 ventilators, people familiar with the plans who asked not to be identified told Reuters.

As part of the effort to boost ventilator output from Ventec, GM has arranged for the supply of 95% of the parts needed to build the ventilator and is seeking to source the remaining 37 necessary parts, according to an email to suppliers from Shilpan Amin, GM’s vice president of global purchasing.

Ventec and GM have been working around the clock to develop the plans to build more ventilators. With GM on board to help, Ventec “is now planning exponentially higher ventilator production as fast as possible,” GM spokesperson Dan Flores told Reuters, adding that the Kokomo plant is the site being targeted to handle the production.

GM suppliers have jumped into action, working to convert their facilities from auto parts to ventilators parts. Additionally, some of Ventech’s suppliers are taking the steps necessary to exponentially grow their production rates to meet the expected demand.
I'd bet that Congress has around 600 ventilators set aside somewhere.
 
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This is the company I have my money on to come out with an effective vaccine against covid2.

https://techcrunch.com/2020/03/23/m...cine-available-to-healthcare-workers-by-fall/

https://www.modernatx.com/modernas-work-potential-vaccine-against-covid-19

Their success rate for other vaccine trials that they have conducted using their unique technology (using mRNA rather than a small sample of the virus being injected into humans) has been 100% effective.

Stay vigilant and survive this year and by next year covid2 will go the way of the Dodo and we can go back to talking about how Schiano is doing.
Agreed. And as I think we were discussing a couple of weeks ago (hard to even think that far back isn't it?), emergency/compassionate use by this fall (especially for healthcare workers) could be in the cards if the trials proceed well, as per the last bullet in the link. Still think the antibody approach will be ready by mid-summer, before even an emergency rollout of a vaccine in the fall. But it's good to have a ton of parallel efforts going on on many treatment and prevention fronts.

On March 23, 2020, Moderna filed a Current Report on Form 8-K which included, among other things, information regarding the potential timing of the availability of a vaccine against COVID-19. The Company reported that the Phase 1 study is proceeding in accordance with the protocol under the direction of NIAID. The Company further reported that while a commercially-available vaccine is not likely to be available for at least 12-18 months, it is possible that under emergency use, a vaccine could be available to some people, possibly including healthcare professionals, in the fall of 2020. Any emergency use would be subject to authorization by the appropriate regulatory agencies, based on the emergence of clinical data for mRNA-1273 that would support use of the vaccine prior to licensure. In addition, the Company confirmed that it is scaling up manufacturing capacity toward the production of millions of doses per month, in the potential form of individual or multi-dose vials. As has previously been disclosed, the ability of the Company to make millions of doses per month is contingent on investments in the scale up and further buildout of the Company’s existing manufacturing infrastructure.
 
Folks, we are straying into politics with this thread, speculating on what the government has, criticizing politicians and government entities, bickering about health care workers going back and forth between NJ and NY, quibbling about what Trump may or may not have said, posting rumors with no backing evidence or articles, posting memes, videos, etc., etc.

Let's dial it back. This thread is meant to be informative for all on the board, as a way of disseminating the latest changes and conditions which may affect all of us, and to open up discussion, where warranted, of how to deal with everything being thrown at us from this virus.
 
The federal government is sitting on a supply of at least 10,000 which they have stated is in their stockpile. So yes they are sitting on it.

I understand they are holding them back because other parts may need them too.

But what they can do is order manufacturers that already make them or others who have similar manufacturing processes to churn them out 24/7. Send those manufacturers any support they need (supplies, workforce, anything). I have not heard that this has been done to a large scale at this point in time.

If the federal government is relying on GM to solve it’s problems, they should release the ventilators from the stockpile and then restock once GM has them produced.

Fridley, Minn.-based Medtronic doubled the number of shifts in manufacturing ventilators at its Galway, Ireland manufacturing facility. The plant is being brought to a 24/7 operation and additional staff is being transferred from other Medtronic sites to increase activities, according to a news release. The company said it is prioritizing high-risk/high-need areas for ventilator allocation on a weekly basis, but is monitoring the situation as it unfolds.

https://biztimes.com/ge-healthcare-to-produce-ventilators-around-the-clock/

“Our dedicated teams are working around the clock to ensure that our customers and partners on the front lines have the equipment and servicing needed to diagnose and treat patients with COVID-19,” Kieran Murphy, president and chief executive officer of GE Healthcare, said in a statement.

Steps the company is taking include adding manufacturing lines to ventilator production and increasing shifts to produce around the clock, hiring additional manufacturing employees, working with supply chain partners to mitigate shortages, monitoring the health of field staff engineers and working with global regulators to help address customer questions about how to meet patient needs.

https://www.massdevice.com/major-u-s-manufacturers-answering-call-for-ventilator-needs/

https://www.kolotv.com/content/news/COVID-19-Buisness-making-ventilators-24-7-569041301.html

Chicago-based Vyaire Medical VP of corporate communications Cheston Turbyfill told The Desert Sun that the company has already doubled its production and will have to push it even further. According to the report, the ventilator-maker is hoping to double its workforce soon as the pandemic rolls on.

Seattle-based ventilator maker Ventec told The Seattle Times that it shipped 250 units of its deployable ventilators last month and is heightening production to potentially 1,000 per month in the next 90 days and 2,000 per month within 120 days. Ventec also reportedly plans to make an additional 100 hires to its current staff of 130.

Ventec is also teaming with GM to produce even more as I stated above. Tesla and Ford are also stepping in.

You can order people to do things all you want but logistics are logistics and things take time.
 
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Did those Israeli's develop the vaccine yet?
Realistically, no vaccine will be available from anywhere for at least 9 months, and maybe as long as 18 months.

In the short term, the best hope is finding an effective treatment. Even if a treatment isn't 100%, it could still provide a huge benefit in helping to reduce hospitalizations, especially severe cases and mortality. That is another way to "flatten the curve".
 
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Realistically, no vaccine will be available from anywhere for at least 9 months, and maybe as long as 18 months.

In the short term, the best hope is finding an effective treatment. Even if a treatment isn't 100%, it could still provide a huge benefit in helping to reduce hospitalizations, especially severe cases and mortality. That is another way to "flatten the curve".

A vaccine can be developed soon, but yeah, clinical trial, etc can take a year
 
Fridley, Minn.-based Medtronic doubled the number of shifts in manufacturing ventilators at its Galway, Ireland manufacturing facility. The plant is being brought to a 24/7 operation and additional staff is being transferred from other Medtronic sites to increase activities, according to a news release. The company said it is prioritizing high-risk/high-need areas for ventilator allocation on a weekly basis, but is monitoring the situation as it unfolds.

https://biztimes.com/ge-healthcare-to-produce-ventilators-around-the-clock/

“Our dedicated teams are working around the clock to ensure that our customers and partners on the front lines have the equipment and servicing needed to diagnose and treat patients with COVID-19,” Kieran Murphy, president and chief executive officer of GE Healthcare, said in a statement.

Steps the company is taking include adding manufacturing lines to ventilator production and increasing shifts to produce around the clock, hiring additional manufacturing employees, working with supply chain partners to mitigate shortages, monitoring the health of field staff engineers and working with global regulators to help address customer questions about how to meet patient needs.

https://www.massdevice.com/major-u-s-manufacturers-answering-call-for-ventilator-needs/

https://www.kolotv.com/content/news/COVID-19-Buisness-making-ventilators-24-7-569041301.html

Chicago-based Vyaire Medical VP of corporate communications Cheston Turbyfill told The Desert Sun that the company has already doubled its production and will have to push it even further. According to the report, the ventilator-maker is hoping to double its workforce soon as the pandemic rolls on.

Seattle-based ventilator maker Ventec told The Seattle Times that it shipped 250 units of its deployable ventilators last month and is heightening production to potentially 1,000 per month in the next 90 days and 2,000 per month within 120 days. Ventec also reportedly plans to make an additional 100 hires to its current staff of 130.

Ventec is also teaming with GM to produce even more as I stated above. Tesla and Ford are also stepping in.

You can order people to do things all you want but logistics are logistics and things take time.
Thanks for posting and these are all great developments, but a few thousand a month is nowhere near enough, and like testing, this is occurring weeks later than it should have been, as we've known for weeks that this was coming.
 
Thanks for posting and these are all great developments, but a few thousand a month is nowhere near enough, and like testing, this is occurring weeks later than it should have been, as we've known for weeks that this was coming.

None of these articles give a date as to when much of this, with respect to the private ventilator companies, was planned. It would seem to me a lot of this was in the works because it takes time to get this type of thing going. Just on boarding the extra staff and training them would seem to me to take a while.
 
None of these articles give a date as to when much of this, with respect to the private ventilator companies, was planned. It would seem to me a lot of this was in the works because it takes time to get this type of thing going. Just on boarding the extra staff and training them would seem to me to take a while.
It's also possible that a single ventilator can be used for 2 patients, by splitting the flow, assuming enough oxygen pressure, but the issue then becomes controlling flow/pressure separately, as patients have individual medical needs. I could imagine that simply getting production of flow controllers could allow this doubling to be done well and this could obviously double capacity. Also, HHS has 20,000 ventilators in the emergency stockpile, most of which should be released to NY, since NY will be facing the crisis first.

Cuomo also just amplified on my point above that NY is being hit first, so send the 20K ventilators in the stockpile to NY now, which should allow NY to handle the peak and then, when critical cases decline, he said NY would be happy to then send ventilators, other supplies and seasoned medical staff to other states to help them in their later peaks.
 
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It's also possible that a single ventilator can be used for 2 patients, by splitting the flow, assuming enough oxygen pressure, but the issue then becomes controlling flow/pressure separately, as patients have individual medical needs. I could imagine that simply getting production of flow controllers could allow this doubling to be done well and this could obviously double capacity. Also, HHS has 20,000 ventilators in the emergency stockpile, most of which should be released to NY, since NY will be facing the crisis first.
Cuomo saying exactly that right now on tv
 
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It's also possible that a single ventilator can be used for 2 patients, by splitting the flow, assuming enough oxygen pressure, but the issue then becomes controlling flow/pressure separately, as patients have individual medical needs. I could imagine that simply getting production of flow controllers could allow this doubling to be done well and this could obviously double capacity. Also, HHS has 20,000 ventilators in the emergency stockpile, most of which should be released to NY, since NY will be facing the crisis first.

Listening to Cuomo right now. How do we know that's not the plan? Does NY have the current bed, electrical, expertise to use 20,000 ventilators right now? What's the need in other parts of the country, not in terms of cases but in terms of infrastructure vs cases? Cuomo has to take care of NY, but the Fed government has responsibility for the other 49 states.
 
It's also possible that a single ventilator can be used for 2 patients, by splitting the flow, assuming enough oxygen pressure, but the issue then becomes controlling flow/pressure separately, as patients have individual medical needs. I could imagine that simply getting production of flow controllers could allow this doubling to be done well and this could obviously double capacity. Also, HHS has 20,000 ventilators in the emergency stockpile, most of which should be released to NY, since NY will be facing the crisis first.

Cuomo also just amplified on my point above that NY is being hit first, so send the 20K ventilators in the stockpile to NY now, which should allow NY to handle the peak and then, when critical cases decline, he said NY would be happy to then send ventilators, other supplies and seasoned medical staff to other states to help them in their later peaks.

Your thoughts on this?
http://systrom.com/blog/the-us-just-crossed-a-dangerous-threshold/
 
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Cuomo saying exactly that right now on tv
Yep, just edited my post to add his comments about wanting the 20K federal stockpile to be released to NY first. Impressed by his command of every element of the response and plans. I wish, though, they would share the slides they show at these pressers, as they're loaded with good info/data. More on the presser...
  • 90K tested in NY now (12,000 yesterday); up to 25K positives in NY (14K in NYC) vs. 48K in US total, with 3200 hospitalized and 756 in ICU (with ventilators).
  • NYs high rate vs. the rest of the US is no surprise - it's due to earlier testing and the very high population density - and most other cities are likely to see similar spikes as NY a bit later on.
  • NY has enough other supplies for immediate needs (masks, gowns, gloves, N95 respirators, etc.), but will need more down the road.
  • NY peak looks to be 14-21 days away, so there is some time, but it's growing short.
 
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Listening to Cuomo right now. How do we know that's not the plan? Does NY have the current bed, electrical, expertise to use 20,000 ventilators right now? What's the need in other parts of the country, not in terms of cases but in terms of infrastructure vs cases? Cuomo has to take care of NY, but the Fed government has responsibility for the other 49 states.

It seems like it’s not the case as of now because he publicly asking for it to be the case.

For example his comment that it is “inexplicable” that they aren’t helping more with regards to the ventilator. He is also asking that they release from the stockpile and use the production act. I don’t see why he would be asking for all of this if there wasn’t a potential issue in the horizon.

Hopefully it will become the case which is what many here are arguing for.
 
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It's accurate and the focus on states is important, as the concept of each state having a curve (each city really) is a good one vs just looking at countries, but these graphs all share one flaw in that they show total cases without factoring in population - that would be a better apples to apples comparison - someone on Medium.com did that, but it's not at my fingertips. I also think NY's numbers are much higher than other states partly due to much more aggressive testing - other states will likely catch up once they start testing more.
 
Apparently the FEMA director said this morning on CNN that were going to use the Defense Productionn Act to direct companies make ventilators, but the administration shot him down.
 
As John Newland would say:"It would be fascinating to know how many of these cases received the regular flu shot last fall."

Especially those who are not elderly.
 
SIAP...don't have time or mental energy to read through all the posts since I last checked in.

Twitter thread from an ER doctor in NYC. This guy worked on ebola patients in Africa and now dealing with a crush of coronavirus patients. Sobering though not much different than other stories that have been posted here already.

(Edit to correct - actually he was also infected by ebola but survived)

 
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