Yes, Pfizer cut estimates of doses by the end of the year in half from a September projection to their early November projection, but the September projection was very early and more of a guesstimate, while the November projection is solid and represents what they already mostly have ready. The combined estimate by the end of the year for both Pfizer and Moderna is 40MM doses for 20MM people, which just about covers the ~21MM health care workers and ~2MM LTC population, i.e., those most at risk.
And Moderna is saying they will have 100-125MM doses during 1Q21, with 85-100MM of those for the US (for 40-50MM people), while Pfizer expects ~100MM doses in 1Q21 (50MM people) and 1.3 billion doses in all of 2021 worldwide. So that's enough for 100MM in the US by the end of 1Q21 (~30% of the population). Throw in the Astra-Zeneca and J&J vaccines, which will very likely also work and be approved by the end of January and there's easily another 100MM doses by the end of 1Q21 for the US (at least 50MM people; J&J is looking at 1 dose). Plus, several more vaccines are likely to be available by March/April.
If things work out well, which I think they will, we're talking about having enough people vaccinated by the end of April to get very close to herd immunity, when factoring in ~30% already likely immune. Having spent 30+ years in Pharma late stage R&D/manufacturing, yes, there is always some risk to any supply chain (and I'm sure there will be some growing pains with distribution), but certainly not to all or most of them at the same time. I'm on the optimistic side with my projections, but even the pessimistic side would likely be that we'll be able to vaccinate >60% of the US by sometime in June.
https://nymag.com/intelligencer/202...t-u-s-covid-19-vaccine-distribution-plan.html
https://time.com/5917847/pfizer-cut-covid-19-vaccine-targets/
https://www.reuters.com/article/us-...doses-globally-in-first-quarter-idUSKBN28D3FA
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So which vaccine is best? Which one would you rather have based upon possible negative reactions ? If I’m betting on this rollout coming off smoothly I’m not expecting it.