While Yahoo! only scolded the other side for doing the same.
Sun’s out, let’s all try and get some Vitamin D. 🌞
OT: COVID Science - Pfizer/Moderna vaccines >90% effective; Regeneron antibody cocktail looks very promising in phase II/III trial and more
- Thread starter RU848789
- Start date
- Status
Sun’s out, let’s all try and get some Vitamin D. 🌞
Hospitals Retreat From Early Covid Treatment and Return to Basics
Changing practices, based on data and experience, appear to be improving outcomes for the sickest coronavirus patients. One key difference: using ventilators in ways that conform more to pre-pandemic guidelines.
www.wsj.com
AUGH. The woman is on record saying they kissed the deadline because there was too much information to put into the system. I hope she's fired.
Lost a family member this past week to COVID in a rehab facility here in NJ where they were recovering from surgery. The facility had/has an ongoing outbreak among staff that has now spread to residents. Turns out the admin was covering up positive staff tests and was sending them back to work while positive. We are beyond livid, and are working with our lawyers on litigation. These admin officials need to be locked away without a key. This should NEVER have happened.
sorry to here this news Joey. Prayers to you and your family
cases in NJ long term care facilities are exploding. We have known from the beginning its staff that spread the infections but yet no one has figured out what to do
In what is poetic justice for our board....the next man up said we probably won’t get everyone vaccinated before end next year... blames the guy now there for all the future delays... so is he correct on the timeline predictions? End of summer...end of Year 2021? Oh do we have any ophthalmologists on the board? For the love of God get JB some reading specs in order to read his teleprompter. He read like a 2nd grader a hillybilly from Rocky Mount NC... oh and vaccinating thousands of inmates with felonies before healthcare, first responders, nursing homes and the over 65 crowd is a complete sham...
Last edited:
Thank you.
If anyone has an elderly family member who needs rehab please try for in-home care if at all possible. Yes it's significantly more expensive but if we had known what the outcome would have been we all would have chipped in to get the in-home care. The current rehab/therapy/LTC facilities in NJ are beyond a disaster. In many cases they are a death sentence right now.
Derek Lowe weighed in today on the issues associated with new variants in the UK and South Africa, largely aligned with the posts I've made, so far, on this, with regard to the big picture, as per the excerpt below. His basic message is we need more data/studies to truly understand whether these variants are more infectious (possible, but certainly not proven yet), more deadly (unlikely), or have any ability to evade antibodies from one's immune system or activated by a vaccine (again, unlikely).
However, he dives much more deeply into the actual mutations, which make for interesting reading and has a nice discussion of the work going on feverishly now to assess the nature and risks from these variants - and includes links to even deeper scientific papers/analyses of these variants if interested. Enjoy and as I said yesterday, "remain calm!"
https://blogs.sciencemag.org/pipeline/archives/2020/12/22/the-new-mutations
So I think the amount of scientific attention being paid to these new strains is completely appropriate. The popular press might be another story. It’s important to remember that (as mentioned) we haven’t even established for sure that these strains are in fact more infectious, and that we don’t know a thing yet for sure about what effect they have in humans compared to the other variants. So if you see any headlines about Relentless March of the Supervirus, go read something else, because that stuff is (fortunately) way out ahead of the facts on the ground. These are by no means the last variants like these that we’re going to be seeing, and we need to learn how to cover them in a responsible way.
So what’s coming next, and when we will know more? We will have animal-model data coming soon to tell us something about infectiousness, and there are already studies underway using human antibody mixtures (from infected patients and vaccinated ones) to see if these new strains are any less susceptible to our immune response. This will be a matter of weeks; I wouldn’t expect to see any clarity before then. And that’s also at least the time scale we would need to start confirming the clinical effects in the human population – you can be sure that medical centers around the world will be monitoring patients who have been confirmed with these variants to see if there are any differences. We’ll also want to know how these look in different age cohorts, in people with pre-existing conditions, and so on, but all of this will take irreducible amounts of time to get a meaningful picture.
My speculations are worth what you’re paying for them. But I think that odds are reasonable that UK strain, based on what we’re seeing so far, may well be more infectious than the existing ones. I hope I’m wrong about that, and I want to re-emphasize that I very well could be. At the same murky level of clarity, I’m not seeing anything so far that makes me think that it causes a worse form of the disease, and I very much hope that I’m not wrong about that. As for vaccine effects, my money is on the antibody response from the vaccines still being protective – and that’s going to be some of the first hard data that we get, because those are some of the most straightforward experiments to run. Updates as we get them.
Got my shot at 9am, no side effects so far, psychologically, a huge boost for front line workers, second dose scheduled for 1/12/21
Last edited:
REPORT: The Murphy Administration wanted mask wearers penalized at COVID-ravaged N.J. veterans homes
TRENTON, N.J. - New Jersey's veterans homes have been among the hardest hit places in the country during the COVID-19 pandemic. Now we have more insight into the reasons behind the severity of the outbreaks, and it doesn't reflect well on the Murphy Administration. On Tuesday, The Record and North
savejersey.com
The Murphy administration is terrible!!
Therapeutic Management of Patients with COVID-19
Last Updated: December 3, 2020
Executive Summary
Two main processes are thought to drive the pathogenesis of COVID-19. Early in the course of the infection, the disease is primarily driven by replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Later in the course of infection, the disease is driven by an exaggerated immune/inflammatory response to the virus that leads to tissue damage. Based on this understanding, it is anticipated that antiviral therapies would have the greatest effect early in the course of disease, while immunosuppressive/anti-inflammatory therapies are likely to be more beneficial in the later stages of COVID-19.
In the earliest stages of infection, before the host has mounted an effective immune response, anti-SARS-CoV-2 antibody-based therapies may have their greatest likelihood of having an effect. In this regard, although there are insufficient data from clinical trials to recommend either for or against the use of any specific therapy in this setting, preliminary data suggests that outpatients may benefit from receiving anti-SARS-CoV-2 monoclonal antibodies early in the course of infection. The anti-SARS-CoV-2 monoclonal antibodies bamlanivimab and casirivimab plus imdevimab are available through Emergency Use Authorizations for outpatients who are at high risk for disease progression.
Remdesivir, an antiviral agent, is currently the only drug that is approved by the Food and Drug Administration for the treatment of COVID-19. It is recommended for use in hospitalized patients who require supplemental oxygen. However, it is not routinely recommended for patients who require mechanical ventilation due to the lack of data showing benefit at this advanced stage of the disease.1-4
Dexamethasone, a corticosteroid, has been found to improve survival in hospitalized patients who require supplemental oxygen, with the greatest effect observed in patients who require mechanical ventilation. Therefore, the use of dexamethasone is strongly recommended in this setting.5-8
The COVID-19 Treatment Guidelines Panel (the Panel) continues to review the most recent clinical data to provide up-to-date treatment recommendations for clinicians who are caring for patients with COVID-19. Figure 1 summarizes the Panel’s recommendations for managing patients with varying severities of disease. A comprehensive summary of the clinical data for the drugs that are being investigated for the treatment of COVID-19 can be found in the Antiviral Therapy, Immune-Based Therapy, and Adjunctive Therapy sections of these Guidelines.
FROM THE LATEST NIH GUIDELINES
Last Updated: December 3, 2020
Executive Summary
Two main processes are thought to drive the pathogenesis of COVID-19. Early in the course of the infection, the disease is primarily driven by replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Later in the course of infection, the disease is driven by an exaggerated immune/inflammatory response to the virus that leads to tissue damage. Based on this understanding, it is anticipated that antiviral therapies would have the greatest effect early in the course of disease, while immunosuppressive/anti-inflammatory therapies are likely to be more beneficial in the later stages of COVID-19.
In the earliest stages of infection, before the host has mounted an effective immune response, anti-SARS-CoV-2 antibody-based therapies may have their greatest likelihood of having an effect. In this regard, although there are insufficient data from clinical trials to recommend either for or against the use of any specific therapy in this setting, preliminary data suggests that outpatients may benefit from receiving anti-SARS-CoV-2 monoclonal antibodies early in the course of infection. The anti-SARS-CoV-2 monoclonal antibodies bamlanivimab and casirivimab plus imdevimab are available through Emergency Use Authorizations for outpatients who are at high risk for disease progression.
Remdesivir, an antiviral agent, is currently the only drug that is approved by the Food and Drug Administration for the treatment of COVID-19. It is recommended for use in hospitalized patients who require supplemental oxygen. However, it is not routinely recommended for patients who require mechanical ventilation due to the lack of data showing benefit at this advanced stage of the disease.1-4
Dexamethasone, a corticosteroid, has been found to improve survival in hospitalized patients who require supplemental oxygen, with the greatest effect observed in patients who require mechanical ventilation. Therefore, the use of dexamethasone is strongly recommended in this setting.5-8
The COVID-19 Treatment Guidelines Panel (the Panel) continues to review the most recent clinical data to provide up-to-date treatment recommendations for clinicians who are caring for patients with COVID-19. Figure 1 summarizes the Panel’s recommendations for managing patients with varying severities of disease. A comprehensive summary of the clinical data for the drugs that are being investigated for the treatment of COVID-19 can be found in the Antiviral Therapy, Immune-Based Therapy, and Adjunctive Therapy sections of these Guidelines.
FROM THE LATEST NIH GUIDELINES
Interesting stuff about Vitamin D and Covid.
www.nutraingredients.com
Experts send Vitamin D and Covid-19 open letter to world's governments
In an open letter being sent to world governments today (21st December), 120 health, science and medical experts from the UK, US, and Europe say there is clear scientific evidence that vitamin D reduces Covid-19 infections, hospitalisations, and deaths.
Today, Dr. Fauci, after receiving his vaccine, reiterated what he and other experts have said, so far, i.e., that we'll be done with the vaccinations of all of the priority groups (health care workers/LTC people by early January, then elderly and those with underlying conditions and front-line workers from Jan-Mar) by the end of March and should start vaccinating "everyone else" by early April, but that it could take a couple of months to vaccinate everyone who requests a vaccine - I'm optimistic that will be by June.
REPORT: The Murphy Administration wanted mask wearers penalized at COVID-ravaged N.J. veterans homes
TRENTON, N.J. - New Jersey's veterans homes have been among the hardest hit places in the country during the COVID-19 pandemic. Now we have more insight into the reasons behind the severity of the outbreaks, and it doesn't reflect well on the Murphy Administration. On Tuesday, The Record and North
The Murphy administration is terrible!!
Well until the press in nj or ny starts doing their job...but they won't ask questions
He was not so optimistic on ABC this morning. Talked about timeliness and admitted no one really knows. Did not dispute those with longer timeliness.
He has repeatedly said what he said last night and today on CNN, with regard to vaccines being generally available to all by early April. How long it takes to provide vaccines to all who want them is an open question, but I'd say by the end of June (since 40% have said they won't get a vaccine) and some say late summer (which I think assumes a far higher percentage get the vaccine).
https://www.dailymail.co.uk/news/ar...ceive-COVID-19-vaccine-early-spring-2021.html
The lack of progress with therapeutics is very disappointing. Seems like we went all in on vaccines but forgot about everything else.
Why there isn’t more focus on therapeutics that can be administered outside of a hospital setting is beyond me. You can’t tell me trials for antivirals and inhaled versions of monoclonal antibodies takes longer than vaccine trials.
Do you treat covid patients in a hospital? If so, any opinion on the growing controversy about ivermectin?
I know there's been some talk in this thread about this recently. Videos in support of ivermectin that wind up on youtube are often removed pretty quickly. I came across this one a couple of hours ago, one of the doctors advocating for ivermectin (Pierre Kory) being interviewed by a doctor in Canada. It's fairly long (about an hour) but interesting if you're into this kind of stuff. One item worth noting is that Kory had to leave his current position at the U of Wisconsin (I think) because his employer tried to put restrictions on him speaking out about this treatment.
Anyway, I don't know how long this video will be available so anyone interested should check it out now.
I wish the HCQ crazies chose Ivermectin instead of HCQ. At least Ivermectin has shown something....but it needs a proper trial. Feels like it’s too late at this point.
IVERMECTIN – STROMECTOL (MSD) (updated 11/4/2020) Dosage: ▪ Dosage for COVID-19 not established 200-400 mcg/kg/dose PO1 ▪ Inhibits SARS-CoV-2 in vitro; ~5000- fold reduction in viral RNA in cell culture 48 hours after a single treatment2 Rajter et al. Chest 20205 (updated 10/26/2020) Population: hospitalized patients (n=280) Design: retrospective cohort; ivermectin compared to usual care ▪ 200 mcg/kg x 1 dose, 2nd dose given after 7 days if still hospitalized Results: ▪ Most patients in both groups also received hydroxychloroquine and/or azithromycin ▪ Ivermectin associated with lower all-cause mortality compared to usual care (15.0% vs 25.2%; p=0.03) ▪ In the propensity-matched cohort, mortality remained lower with ivermectin (13.3% vs 24.5%; OR 0.47, CI 0.22-0.99; p<0.05) ▪ In 75 patients with severe pulmonary disease, mortality was lower with ivermectin (38.8% vs 80.7%, p=0.001) ▪ No significant difference in extubation rates (36.1% vs 15.4%, p=0.07) Limitations: retrospective data; intervention timing not standardized Adverse Effects: ▪ Generally well tolerated when used for treatment of lice; diarrhea has occurred ▪ Diarrhea, nausea, dizziness, pruritis, dermatologic reactions, lymphadenitis, arthralgia, and fever have been reported when used for treatment of onchocerciasis Drug Interactions: ▪ Azithromycin may increase serum concentrations of ivermectin ▪ FDA-approved for treatment of intestinal strongyloidiasis and onchocerciasis; used off-label for a variety of other parasitic infections including lice and scabies ▪ Inhibited SARS-CoV-2 in vitro; may inhibit nuclear transport activity ▪ NIH guidelines recommend against use, except in a clinical trial3 (updated 8/29/2020) ▪ FDA warns against human use of ivermectin intended for use in animals4 ▪ Results of an in vitro study suggest that ivermectin concentrations needed to inhibit SARS-CoV-2 in humans may not be achievable without toxic dosages of the drug6 (updated 10/26/2020) Pregnancy: ▪ Limited data available in pregnant women - 88 - IVERMECTIN (continued) R Mahmud et al. 20207 (added 10/26/2020) Population: patients with mild to moderate COVID-19 in Bangladesh (n=400) Design: randomized, double-blind, placebo-controlled ▪ Ivermectin + doxycycline added to standard care vs placebo plus standard care ▪ Ivermectin 6 mg stat; doxycycline 100 mg bid x 5 days Results: ▪ More patients receiving ivermectin + doxycycline had early clinical improvement (60.7% vs 44.4%: p<0.03) ▪ Fewer patients receiving ivermectin + doxycycline had late clinical recovery (23.0% vs 37.2%; p<0.004) Limitations: limited information available; has not been published or become available on a pre-print server; not peer reviewed HA Hashim et al. MedRxiv 2020 8 (added 11/4/2020) Population: outpatients or inpatients in Baghdad with COVID-19 with severity ranging from mild to critical (most patients had mild to moderate disease) (n=140) Design: randomized controlled trial Ivermectin (200 mcg/kg/day x 2 days; some patients received a 3rd dose 7 days after the 1st) plus doxycycline (100 mg bid x 5-10 days) added to standard care vs standard care alone - 89 - IVERMECTIN (continued) Results: ▪ Patients with critical disease were not included in the control group ▪ 3/70 patients (4.28%) treated with ivermectin/doxycycline and 7/70 patients (10%) given standard care alone progressed to more advanced COVID-19 (p>0.05) ▪ Among patients with severe disease at randomization, 9% (1/11) given the active treatment and 31.81% (7/22) given standard care progressed to more advanced disease (p>0.05) ▪ Mortality rate in patients with severe disease was 0% (0/11) in patients treated with ivermectin/doxycycline and 27.27% (6/22) in those given standard care (p=0.14) ▪ Mean time to recovery was 10.61 days with ivermectin/doxycycline vs 17.9 days with standard care (p<0.05) Limitations: not peer reviewed, small sample size, single-blind
Looks promising-but needs far more rigorous testing before the FDA will even sniff this
Looks promising-but needs far more rigorous testing before the FDA will even sniff this
Last edited:
Well, it’s a two dose vaccine, so they were probably already planning on it
For sure. I don't expect FDA or NIH or any of those to get around to evaluating/promoting the stuff in time to make a difference (if it really works). I don't even know if any trials are being done in the US.
There apparently are a bunch of other similar studies (Kory has written a review article that is available on one of the preprint servers). All supposedly show strong benefit for ivermectin treatment. I've read/heard enough to know that I want it if I get covid. My opinion may change as more studies are done, but right now the only other choice if you get covid is stay home and hope you're not one of the unlucky ones.
Would love for ivermectin to work, as I worked on the drug a bit in the late 80s/early 90s, but this looks like another HCQ, as both are anti-parasitic compounds that show in-vitro activity against SARS-CoV-2, but have shown mixed results in clinical trials, to date, except HCQ was completely ineffective in every well run RCT (randomized controlled trial) and I don't think any well run RCTs have been run on ivermectin so far.
Given some promising results, I'd have no issue with running a well-controlled trial, but I agree with the NIH Guidelines on Ivermectin to only allow use in such approved trials and not to get an EUA for use in COVID patients. Especially because the dose that would be needed to attain the blood levels seen to have an antiviral effect in-vitro is 100X the approved human dose (as an anti-parasitic - it's been fantastic for river blindness for decades at very low doses).
https://apnews.com/article/fact-checking-afs:Content:9768999400
https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/ivermectin/
Last edited:
No #’s it’s not happening ...and this 40% is a crock BS... You’re next guy up said today... gonna be dark times ahead... now how sad is that? But we’re gonna give these vaccines to felons in prisons before first responders, healthcare workers , teachers, nursing facilities, caregivers in those VA hospitals... and he reads as a 2nd grader On his teleprompter stating end of year and not 2020... I will bet you if available ( it won’t be) at minimum 60-65% will get the vaccine... if the new strain is here already and it probably is people will be stepping over themselves to get it...everything after the new guy takes over will be blamed on the past administration... no secret he is lost and confused... by this guy a pair of glasses.
One period ends a sentence. I cant take it anymore. As to whether or not you want to go with the double space after the period, that can get trivial. But for the love of Jesus, end a sentence with one period. It is impossible to take anything you say seriously when every sentence ends in ...
Been around forever. There is an animal version and human version. Human version shows great potential. I have multiple friends taking it. It’s cheap and has shown to greatly reduce risk of infection. Don’t take animal version. Lol
Rather than making error-filled posts, do a little research first, as your ridiculous claims are easy to check - try Google. The latest polling indicates that 60% of Americans will get the vaccine, so 40% wouldn't, as per the link below. I actually believe 70% will get the vaccine, so there's nothing to bet on, since that exceeds your 60-65% estimate, which is the same as the 40% I said who won't get it above - did you misread my post?
Also, do you want your President to tell you the truth, which is our darkest times are ahead of us, as the next 4-6 weeks will be the worst of the pandemic, especially as the Christmas-induced peak hits in January and before enough are vaccinated to make a big difference (except perhaps for reduced deaths in the elderly)? Or would you rather have him say it's going to just magically disappear?
I also thought his remarks were fine and I especially liked the honest, caring message preparing us for tough times, but urging everyone to stick together and get their vaccines and wear masks and be careful (I wish we had been hearing messages like that before). He may have stumbled over a word or two, but does that really matter that much to you?
And one state, so far, is prioritizing prisoners (and the homeless, both of which are major disease vectors) ahead of the elderly and front-line workers, but not in front of first responders or health care workers or those in nursing facilities - they are first everywhere, so you got that wrong also (2nd link).
https://www.webmd.com/vaccines/covi...ns-increasinglyi-say-theyll-get-covid-vaccine
https://www.nytimes.com/2020/12/18/health/coronavirus-vaccine-prisons-massachusetts.html
Wait just one second. Two spaces after a period!! Or at least that's how I was taught, lol...(I do like the ellipsis, though, but not more than one per post)
I had my single space conversion forced upon me by an intern in 07.
Bobs pure insanity. Have to give it to numbers for using that much of your personal time to write reasoned responses. I personally, don’t think it’s worth it.
Say it ain't so! And please don't ruin Christmas by telling me you don't use the Oxford comma...
This vaccine tracker from Bloomberg is pretty cool. Shows 2.4MM vaccinated worldwide and 776K in the US, through today. I assume it's updated daily. I don't think we'll make it to 20MM in the US by the end of the year, as hoped, but I'd guess by about a week or so later.
Also, for people nervous about vaccine distribution, I'm pretty sure if we can vaccinate 65% of children and ~50% of Americans over 3-4 months for influenza, we can vaccinate the ~60% of adult Americans who say they will get a vaccine between now and the end of April (that's 160MM people and we should have doses for 200MM by the end of June, so it might take until past the end of April by a bit). The distribution system for COVID is essentially identical to what we've been doing for the flu for decades, apart from the cryogenic storage requirements for the Pfizer vaccine, which isn't that complicated really (just needs dry ice).
https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/
Also, for people nervous about vaccine distribution, I'm pretty sure if we can vaccinate 65% of children and ~50% of Americans over 3-4 months for influenza, we can vaccinate the ~60% of adult Americans who say they will get a vaccine between now and the end of April (that's 160MM people and we should have doses for 200MM by the end of June, so it might take until past the end of April by a bit). The distribution system for COVID is essentially identical to what we've been doing for the flu for decades, apart from the cryogenic storage requirements for the Pfizer vaccine, which isn't that complicated really (just needs dry ice).
https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/
Last edited:
I can't believe GoRU(?) didn't post this release about Cytodyn's leronlimab monoclonal antibody drug, which is a CCR5 (chemokine receptor) antagonist that has been repurposed for COVID to help halt over-inflammatory responses to the virus in severely ill COVID patients. They completed their phase III enrollment and expect results in mid-January. Let's hope it works - I'm sure he has a lot invested and can donate millions to RU football should the drug work.
https://www.proactiveinvestors.com/...ere-to-critical-covid-19-patients-937181.html
https://www.proactiveinvestors.com/...ere-to-critical-covid-19-patients-937181.html
Someone has a sarcasm detector that isn't working. But thanks for trying to help out sweet heart.
- Status
Latest posts
-
FB Recruiting 10+ Rutgers Football Transfer Portal entries this morning.....- Latest: Rusty_Screw_88
-
-
