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OT: oh oh oh Ozempic !

I can't say if taking this is good or bad in the short term or might hurt your health in the long run.
But like most drugs that come on the scene that seem to be a great thing ot might be wise to go a different route before taking this new cure.
I'd try conventional methods supervised by doctors and nutritionists before jumping on the bandwagon.
If the conventional ways don't seem to be helping, then this drug might be worth a try.
 
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It’s definitely helped me. Been on it since April. Down 50 pounds. I had an issue with constant binge eating. Overeating. This has reduced the “food chatter” in my mind, and has helped me stop eating when I’m full. I’ll deal with issues if they happen, but this has helped me lose weight, control my cholesterol, high blood pressure, and sleep apnea.

side effects I was told about were nausea and heartburn. Honestly after the first dose, I didn’t feel any nausea, haven’t since. Heartburn was a little worse than I normally experience but otc omeprazole helps it just fine. Wasn’t told of any long term effects

Good stuff in this thread . Seems like only one poster has personal experience and it seems good.
Maybe it is the miracle drug
 
No

Not really. Weird flex for you. Pharma and big food want to sell more product. They don't care about healthy people. Make them fat and sick, prescribe a drug with side effects, and prescribe another drug for the side effects. Lather, rinse, repeat.
Sorry, but it's stupid to blame food companies for fat, lazy people that overeat. Nutrition info is available and has been for a long, long time. No excuses (just like smoking).
 
It’s definitely helped me. Been on it since April. Down 50 pounds. I had an issue with constant binge eating. Overeating. This has reduced the “food chatter” in my mind, and has helped me stop eating when I’m full. I’ll deal with issues if they happen, but this has helped me lose weight, control my cholesterol, high blood pressure, and sleep apnea.
Congrats! Great to hear that the wonderful and noble pharma industry helped you get healthier. These medications may truly change society for the better.
 
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Weirdest flex of the thread. First, I wish you good health and that your medical team finds a long term solution to your issue. Second, you post confirms that I have you on ignore for good reason. Nuance matters.

Not sure what you mean by nuance. You are putting forward generalized conspiracy theories linking pharma to not caring about patients. That could be interpreted as advocating for not using Pharma products. Not sure how you don't realize that. I gave a personal example regarding how Pharma can be potentially life altering/saving. I know a lot of people who work or worked in Pharma and pretty much all have very good motives while you refer to Big Pharma as "they" which is a generalized negative indictment of anyone who potentially even works or supports that industry.

As far as the ignore feature LOL. Nice nuanced personal attack that has nothing to do with the issue we are discussing.
 
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I can't say if taking this is good or bad in the short term or might hurt your health in the long run.
But like most drugs that come on the scene that seem to be a great thing ot might be wise to go a different route before taking this new cure.
I'd try conventional methods supervised by doctors and nutritionists before jumping on the bandwagon.
If the conventional ways don't seem to be helping, then this drug might be worth a try.
I think that’s usually how it works for most people. I don’t think it’s the first option but more an option that is used when other things didn’t work.
 
Not sure what you mean by nuance. You are putting forward generalized conspiracy theories linking pharma to not caring about patients. That could be interpreted as advocating for not using Pharma products. Not sure how you don't realize that. I gave a personal example regarding how Pharma can be potentially life altering/saving. I know a lot of people who work or worked in Pharma and pretty much all have very good motives while you refer to Big Pharma as "they" which is a generalized negative indictment of anyone who potentially even works or supports that industry.

As far as the ignore feature LOL. Nice nuanced personal attack that has nothing to do with the issue we are discussing.
Knight Shift seems to blame a lot of other people for his past unhealthy habits. This is where his conspiracy theories originate from.
 
Knight Shift seems to blame a lot of other people for his past unhealthy habits. This is where his conspiracy theories originate from.

Must be, seem to have hit a personal touchy nerve that he reverted almost immediately to personal attacks.
 
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I’m going on it as soon as I can get it. Which you haven’t been able to get the starting dose since the fall. I’ve been heavy my whole life, done every diet, lose weight put it back on, lose weight put it back on. I personally know 3 people who are just like me and are on it and are now thinner then they ever have been and all their other health problems are much better. I see it as being Fat and everything that comes along with that versus unknown possible long term effects. F’ it. I’m rolling the dice.
 
That’s how it should work. But from what I see that’s not what is happening with ozempic. People telling doctors they tried everything bs. Docs happy to write the scrips . Or write it for the person that needs to lose “the last 20”
 
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I’m going on it as soon as I can get it. Which you haven’t been able to get the starting dose since the fall. I’ve been heavy my whole life, done every diet, lose weight put it back on, lose weight put it back on. I personally know 3 people who are just like me and are on it and are now thinner then they ever have been and all their other health problems are much better. I see it as being Fat and everything that comes along with that versus unknown possible long term effects. F’ it. I’m rolling the dice.
I just know 2 people that got the starting dose. That is part of why I made the original post. They are not diabetics and Not obese . Just fat and looking to lose weight as part of New Year’s resolutions
 
Disclosure, I’ve been in pharma biotech industry over 20 years. There have been some bad actors that have soured people on the space but the degrees of difficulty and innovation are high. Ethics and patient safety are paramount, can’t cut corners. Highly regulated. I don’t work in metabolic or diabetes space now but GLP-1 agonists like Ozempic hold promise in other conditions that are centrally regulated, perhaps some forms of addiction. Still quite early.

I don’t think we fully know how long should be on drug for weight loss and what happens when stop taking it, if have weight gain and how much. It is quite strong for type 2 diabetes who also benefit from weight loss. Also not clear where weight loss coming from.

But, IMO, like most things, this is not a recreational drug to be taken to cut corners in losing weight.

Re measles comeback, it would help if people actually did what they are supposed to do and get vaccinated.
 
This X1000. Any doctor whose fist line is a drug like this instead of diet and exercise should lose their license.

Processed foods and seed oils and sugar are the culprits. Eat whole foods, watch saturated fat intake, and the weight will come off.
We agree. People should always try diet and exercise first and not pharmaceuticals for chronic/lifestyle conditions, IMO. Unfortunately, that's not the way our society works - too many people want instant gratification and results without effort. Also, some people simply can't overcome their own biology (like diabetes, glaucoma, certain heart diseases, cancer, etc.) and pharmaceuticals are often lifesavers/life improvers for these people. I am still a big proponent of the incredible breakthroughs Pharma has made over decades, especially with regard to vaccines, antibiotics, oncology and acute care/surgery, but sometimes usage is overdone.

Having said all that, though, Pharma is still >>>>> neutraceuticals, which are generally not tested clinically and have almost no safety/quality oversight with regard to manufacturing or side effects, as they're not governed by the FDA, like pharmaceuticals and vaccines are, which are held to highly rigorous manufacturing and clinical trial standards.
 
Disclosure, I’ve been in pharma biotech industry over 20 years. There have been some bad actors that have soured people on the space but the degrees of difficulty and innovation are high. Ethics and patient safety are paramount, can’t cut corners. Highly regulated. I don’t work in metabolic or diabetes space now but GLP-1 agonists like Ozempic hold promise in other conditions that are centrally regulated, perhaps some forms of addiction. Still quite early.

I don’t think we fully know how long should be on drug for weight loss and what happens when stop taking it, if have weight gain and how much. It is quite strong for type 2 diabetes who also benefit from weight loss. Also not clear where weight loss coming from.

But, IMO, like most things, this is not a recreational drug to be taken to cut corners in losing weight.

Re measles comeback, it would help if people actually did what they are supposed to do and get vaccinated.
Great post. And people should be worried about the decreased uptake of childhood vaccines, which is threatening the entire population with future outbreaks of previously controlled infectious diseases like measles, polio, mumps, etc. Really good article on this in the link below. Sadly, the antiscientific backlash against mRNA vaccines, which have saved millions of lives and won the Nobel Prize last year in Medicine, is now fueling the backlash against vaccines of all kinds, which is scary, as vaccines, antibiotics and clean water are the cornerstones of how life expectancy went from about 50 in 1900 to nearly 80 now.

https://jamanetwork.com/journals/jama/fullarticle/2813910
 
We agree. People should always try diet and exercise first and not pharmaceuticals for chronic/lifestyle conditions, IMO. Unfortunately, that's not the way our society works - too many people want instant gratification and results without effort. Also, some people simply can't overcome their own biology (like diabetes, glaucoma, certain heart diseases, cancer, etc.) and pharmaceuticals are often lifesavers/life improvers for these people. I am still a big proponent of the incredible breakthroughs Pharma has made over decades, especially with regard to vaccines, antibiotics, oncology and acute care/surgery, but sometimes usage is overdone.

Having said all that, though, Pharma is still >>>>> neutraceuticals, which are generally not tested clinically and have almost no safety/quality oversight with regard to manufacturing or side effects, as they're not governed by the FDA, like pharmaceuticals and vaccines are, which are held to highly rigorous manufacturing and clinical trial standards.
So numbers you think the ozempic craze is good? It works miracles for the fat and obese?
 
Disclosure, I’ve been in pharma biotech industry over 20 years. There have been some bad actors that have soured people on the space but the degrees of difficulty and innovation are high. Ethics and patient safety are paramount, can’t cut corners. Highly regulated. I don’t work in metabolic or diabetes space now but GLP-1 agonists like Ozempic hold promise in other conditions that are centrally regulated, perhaps some forms of addiction. Still quite early.

I don’t think we fully know how long should be on drug for weight loss and what happens when stop taking it, if have weight gain and how much. It is quite strong for type 2 diabetes who also benefit from weight loss. Also not clear where weight loss coming from.

But, IMO, like most things, this is not a recreational drug to be taken to cut corners in losing weight.

Re measles comeback, it would help if people actually did what they are supposed to do and get vaccinated.
Yeah but People are taking it recreationally and to cut corners. Thats the whole point of the thread
It’s the sales reps and doctors that need to be worried about more than the people in white coats inventing this
 
So numbers you think the ozempic craze is good? It works miracles for the fat and obese?
I think it may well be a miracle for many, but since we know that diet/exercise can work for many people to lose weight and those two things are usually good for people regardless of their weight, I think they should be tried first (really tried). I'm also not fond of extrapolating studies that went for 30-56 weeks, generally (Ozempic) to potentially years or the rest of one's life for a huge % of the population all at once. I just worry about undiscovered side effects.
 
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I think it may well be a miracle for many, but since we know that diet/exercise can work for many people to lose weigh and those two things are usually good for people regardless of their weight, I think they should be tried first (really tried). I'm also not fond of extrapolating studies that went for 30-56 weeks, generally (Ozempic) to potentially years or the rest of one's life for a huge % of the population all at once. I just worry about undiscovered side effects.
Yes , good points. I think the issue is that now people are getting their hands on this drug without really trying diet and excercise . If it works without side effects, that is still good.
 
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So far into this thread, no one has posted anything about them or others having bad side effects on ozempic. Maybe it is a miracle drug
 
Disclosure, I’ve been in pharma biotech industry over 20 years. There have been some bad actors that have soured people on the space but the degrees of difficulty and innovation are high. Ethics and patient safety are paramount, can’t cut corners. Highly regulated. I don’t work in metabolic or diabetes space now but GLP-1 agonists like Ozempic hold promise in other conditions that are centrally regulated, perhaps some forms of addiction. Still quite early.

I don’t think we fully know how long should be on drug for weight loss and what happens when stop taking it, if have weight gain and how much. It is quite strong for type 2 diabetes who also benefit from weight loss. Also not clear where weight loss coming from.

But, IMO, like most things, this is not a recreational drug to be taken to cut corners in losing weight.

Re measles comeback, it would help if people actually did what they are supposed to do and get vaccinated.
Most of the reforms happened after Merck's massive Vioxx scandal that really stained the industry. Thankfully, we are much more regulated and have enhanced safeguards against such bad actors.
 
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We agree. People should always try diet and exercise first and not pharmaceuticals for chronic/lifestyle conditions, IMO. Unfortunately, that's not the way our society works - too many people want instant gratification and results without effort. Also, some people simply can't overcome their own biology (like diabetes, glaucoma, certain heart diseases, cancer, etc.) and pharmaceuticals are often lifesavers/life improvers for these people. I am still a big proponent of the incredible breakthroughs Pharma has made over decades, especially with regard to vaccines, antibiotics, oncology and acute care/surgery, but sometimes usage is overdone.

Having said all that, though, Pharma is still >>>>> neutraceuticals, which are generally not tested clinically and have almost no safety/quality oversight with regard to manufacturing or side effects, as they're not governed by the FDA, like pharmaceuticals and vaccines are, which are held to highly rigorous manufacturing and clinical trial standards.
I was worried when I saw you replied, and it's nice to see we agree. T2K's response is, as usual, trite and condescending. Most people have been terribly mislead by large food companies, the government, their medical team, the education system and society as a whole. What do hospitals provide as a breakfast food? Corn flakes, orange juice and white toast--one may as well mainline liquid sugar into their veins.

Diabetes runs in our family. My father died 2 months after turning 70 over 25 years ago. I was trending towards diabetes, and despite being "fairly healthy" for most of my adult life, I needed to take a deep dive and a close look at the foods we kept in our home and were eating. We only eat whole foods now (lots of protein from fish and poultry, vegetables, low sugar fruits such as blueberries, lots of fiber from natural sources, fresh brewed tea, and lots of water).

As I started with my redo of my diet, my old family doctor's first line for my high cholesterol was "take a statin." Nothing on diet. Just- you could lose some weight. There was candy in the waiting room of the doctor's office. 🤦‍♂️Hospitals have soda and candy machines all over the place. So do schools (that seems to be changing a little bit). But Kraft foods recently got a huge contract to serve that garbage lunchables in schools. Garbage is being kind.

Back to me. When I cleaned up my diet, the weight flew off. I experimented with my macros for protein/fat/fiber, and I found that saturated fat had a very bad impact on my cholesterol. By making some changes in my diet, I lowered my cholesterol by 30-40%. I still have some work to do. But my insulin sensitivity/resistance numbers improved markedly too.

Back to statins. As I went to a couple of different cardiologists, a lipidologist and gained a lot of information from a few lipidologists who are very active online, I became very steeped in the two main mechanisms of how the body produces and absorbs cholesterol, raising the values when you get your lipid readings. I found that there is a test called a cholesterol balance test that can be used to measure phytosterol concentrations. I learned that I was an overabsorber, and that in this case, statins may not have much of an impact on lowering my cholesterol. I started taking ezetimibe, which acts in the digestive tract, not the liver, which is a different pathway than the statin works. I also got the OK to take an herbal supplement called berberine, which is approved in Europe for lowering cholesterol (but of course, in the US many doctors laugh at herbal supplements). Berberine functions as a PCSK9 inhibitor. PSCK9i's are avaialbe in the US as a very expensive injetctable pharma (surprise again) for about $500/month. I will be getting a new lipid panel soon.

I recognize that for some patients, statins are beneficial. But a lot of people experience bad side effects. There are statins that can avoid these side effects. But there are a lot of other alternatives to statins, and some are cost prohibitive. The medical community (e.g., my doctor) however, tends to think every cholesterol problem is a nail and a statin is the only tool avaiable to treat it.
 
Good thread topic, by the way...
Thanks . I knew of people going on this for diabetes . But when I heard of people slightly overweight people getting prescribed this to inject at home just to drop a few lbs for New Year’s resolutions, i wondered wtf. Is this for real?
 
I was worried when I saw you replied, and it's nice to see we agree. T2K's response is, as usual, trite and condescending. Most people have been terribly mislead by large food companies, the government, their medical team, the education system and society as a whole. What do hospitals provide as a breakfast food? Corn flakes, orange juice and white toast--one may as well mainline liquid sugar into their veins.

Diabetes runs in our family. My father died 2 months after turning 70 over 25 years ago. I was trending towards diabetes, and despite being "fairly healthy" for most of my adult life, I needed to take a deep dive and a close look at the foods we kept in our home and were eating. We only eat whole foods now (lots of protein from fish and poultry, vegetables, low sugar fruits such as blueberries, lots of fiber from natural sources, fresh brewed tea, and lots of water).

As I started with my redo of my diet, my old family doctor's first line for my high cholesterol was "take a statin." Nothing on diet. Just- you could lose some weight. There was candy in the waiting room of the doctor's office. 🤦‍♂️Hospitals have soda and candy machines all over the place. So do schools (that seems to be changing a little bit). But Kraft foods recently got a huge contract to serve that garbage lunchables in schools. Garbage is being kind.

Back to me. When I cleaned up my diet, the weight flew off. I experimented with my macros for protein/fat/fiber, and I found that saturated fat had a very bad impact on my cholesterol. By making some changes in my diet, I lowered my cholesterol by 30-40%. I still have some work to do. But my insulin sensitivity/resistance numbers improved markedly too.

Back to statins. As I went to a couple of different cardiologists, a lipidologist and gained a lot of information from a few lipidologists who are very active online, I became very steeped in the two main mechanisms of how the body produces and absorbs cholesterol, raising the values when you get your lipid readings. I found that there is a test called a cholesterol balance test that can be used to measure phytosterol concentrations. I learned that I was an overabsorber, and that in this case, statins may not have much of an impact on lowering my cholesterol. I started taking ezetimibe, which acts in the digestive tract, not the liver, which is a different pathway than the statin works. I also got the OK to take an herbal supplement called berberine, which is approved in Europe for lowering cholesterol (but of course, in the US many doctors laugh at herbal supplements). Berberine functions as a PCSK9 inhibitor. PSCK9i's are avaialbe in the US as a very expensive injetctable pharma (surprise again) for about $500/month. I will be getting a new lipid panel soon.

I recognize that for some patients, statins are beneficial. But a lot of people experience bad side effects. There are statins that can avoid these side effects. But there are a lot of other alternatives to statins, and some are cost prohibitive. The medical community (e.g., my doctor) however, tends to think every cholesterol problem is a nail and a statin is the only tool avaiable to treat it.
Statins literally have saved millions and millions of lives since being introduced to the market. Like with all medications, I would stay away from max approved dosages. For those that can't tolerate statins or want to avoid systemic medications, there are plenty of other options.

One of the most exciting biotech initiatives is from a company called Verve Therapeutics. They are working on a gene-editing program that would actually turn off the PCSK9 gene (and thus the troublesome protein). Wild stuff!
 
Most of the reforms happened after Merck's massive Vioxx scandal that really stained the industry. Thankfully, we are much more regulated and have enhanced safeguards against such bad actors.
Nice try, but wrong, as usual. The VIOXX mess never resulted in any criminal findings against Merck and the vast majority of the lawsuits were settled out of court, after Merck won case after case on product liability (MK won 4 of 6, lost one and one was a hung jury), such that most litigants were happy to take the settlement, since they were likely to lose in court.

The VIOXX case wasn't even in the top 5 of all-time damage awards from juries as per the link below, which includes truly heinous behavior, like the role of Purdue in the opiod crisis - at least Merck withdrew VIOXX from the market voluntarily once the risks were better known.

VIOXX was actually a "miracle drug" that countless docs and patients said was the best pain reliever ever, but unfortunately it did have rare heart attack side effects that became clearer after approval - and Ozempic could end up with undiscovered side effects when used in very large populations for years.

https://www.enjuris.com/blog/resour...ellbutrin, Avandia,under the False Claims Act.

https://www.drugwatch.com/vioxx/lawsuits/

The VIOXX case and many others, which were far worse, as per the link, have certainly driven changes in how Pharma conducts clinical trials and markets drugs, although I still say DTC (direct to consumer advertising) has given Pharma a black eye, since so much $$ is spent on marketing/advertising instead of new drugs/R&D, with docs as much more effective gatekeepers of patient safety than they are now.
 
Nice try, but wrong, as usual. The VIOXX mess never resulted in any criminal findings against Merck and the vast majority of the lawsuits were settled out of court, after Merck won case after case on product liability (MK won 4 of 6, lost one and one was a hung jury), such that most litigants were happy to take the settlement, since they were likely to lose in court.

The VIOXX case wasn't even in the top 5 of all-time damage awards from juries as per the link below, which includes truly heinous behavior, like the role of Purdue in the opiod crisis - at least Merck withdrew VIOXX from the market voluntarily once the risks were better known.

VIOXX was actually a "miracle drug" that countless docs and patients said was the best pain reliever ever, but unfortunately it did have rare heart attack side effects that became clearer after approval - and Ozempic could end up with undiscovered side effects when used in very large populations for years.

https://www.enjuris.com/blog/resources/largest-pharmaceutical-settlements-lawsuits/#:~:text=Drugs: Paxil, Wellbutrin, Avandia,under the False Claims Act.

https://www.drugwatch.com/vioxx/lawsuits/

The VIOXX case and many others, which were far worse, as per the link, have certainly driven changes in how Pharma conducts clinical trials and markets drugs, although I still say DTC (direct to consumer advertising) has given Pharma a black eye, since so much $$ is spent on marketing/advertising instead of new drugs/R&D, with docs as much more effective gatekeepers of patient safety than they are now.
$5B in settlements. LOL! Merck hiding the Vioxx data led to the most radical and meaningful clinical trial reforms ever (of course, after killing a bunch of people).

Nice try. What Merck did with Vioxx was disgusting.
 
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I was worried when I saw you replied, and it's nice to see we agree. T2K's response is, as usual, trite and condescending. Most people have been terribly mislead by large food companies, the government, their medical team, the education system and society as a whole. What do hospitals provide as a breakfast food? Corn flakes, orange juice and white toast--one may as well mainline liquid sugar into their veins.

Diabetes runs in our family. My father died 2 months after turning 70 over 25 years ago. I was trending towards diabetes, and despite being "fairly healthy" for most of my adult life, I needed to take a deep dive and a close look at the foods we kept in our home and were eating. We only eat whole foods now (lots of protein from fish and poultry, vegetables, low sugar fruits such as blueberries, lots of fiber from natural sources, fresh brewed tea, and lots of water).

As I started with my redo of my diet, my old family doctor's first line for my high cholesterol was "take a statin." Nothing on diet. Just- you could lose some weight. There was candy in the waiting room of the doctor's office. 🤦‍♂️Hospitals have soda and candy machines all over the place. So do schools (that seems to be changing a little bit). But Kraft foods recently got a huge contract to serve that garbage lunchables in schools. Garbage is being kind.

Back to me. When I cleaned up my diet, the weight flew off. I experimented with my macros for protein/fat/fiber, and I found that saturated fat had a very bad impact on my cholesterol. By making some changes in my diet, I lowered my cholesterol by 30-40%. I still have some work to do. But my insulin sensitivity/resistance numbers improved markedly too.

Back to statins. As I went to a couple of different cardiologists, a lipidologist and gained a lot of information from a few lipidologists who are very active online, I became very steeped in the two main mechanisms of how the body produces and absorbs cholesterol, raising the values when you get your lipid readings. I found that there is a test called a cholesterol balance test that can be used to measure phytosterol concentrations. I learned that I was an overabsorber, and that in this case, statins may not have much of an impact on lowering my cholesterol. I started taking ezetimibe, which acts in the digestive tract, not the liver, which is a different pathway than the statin works. I also got the OK to take an herbal supplement called berberine, which is approved in Europe for lowering cholesterol (but of course, in the US many doctors laugh at herbal supplements). Berberine functions as a PCSK9 inhibitor. PSCK9i's are avaialbe in the US as a very expensive injetctable pharma (surprise again) for about $500/month. I will be getting a new lipid panel soon.

I recognize that for some patients, statins are beneficial. But a lot of people experience bad side effects. There are statins that can avoid these side effects. But there are a lot of other alternatives to statins, and some are cost prohibitive. The medical community (e.g., my doctor) however, tends to think every cholesterol problem is a nail and a statin is the only tool avaiable to treat it.
I worked in Pharma for 30+ years, but am pretty conservative in taking them. I only take a baby aspirin and low dose Crestor for lipids. While I know diet/exercise can be quite effective for some in addressing obesity, diabetes and even lipid levels, I have a hard part with the diet part, as I like the crappy foods I eat, lol, but I have made some changes towards more fruits/veggies and less refined foods. I've always been a bit active, but much moreso in retirement with ~30 min of exercise most days aimed at my various maladies (shoulder, knee, back/disc, feet, etc.) which I got from doing PT, and fairly vigorous walking most days playing disc golf or just walking with my wife, plus weekly soccer.

But we disagree somewhat on statins and significantly on herbal supplements. Statins are probably the best tested/evaluated drugs in history and the benefits are significant for most people, although there are side effects and diet/exercise can be effective too, so prescribing statins shouldn't be an automatic, just like prescribing Ozempic shouldn't me, IMO. Herbal supplements, in general, have never been evaluated in randomized controlled clinical trials and their manufacture is not subject to the rigors of FDA oversight, so their quality (active ingredients and contaminants) is not controlled like pharmaceuticals are. Berberine has not had the large scale RCTs conducted to firmly establish efficacy and patient safety - doesn't mean it's not possible it's helpful, but the data just aren't there yet.

I was working on a novel PCSK9 inhibitor (orally bioavailable) when I left Merck - it... started phase III trials earlier this year.

https://www.aafp.org/pubs/afp/afp-c...ks-rigorous-evidence-has-potential-harms.html
 
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Measles in Philly - began with a kid who brought it from another country (of course). Its odd to always be blaming the unvaccinated while letting millions of ill and unvaccinated anons in unscreened.

As for pharmas - I like one - Regeneron (local).

One of their founders gave a local HS (AOC's!) address at graduation and had the hivers pulling their hair out - lol "go pharmer!" I would trust Regeneron on most things without breaking into sweats

The outbreak began after a child who'd recently spent time in another country was admitted to the Children’s Hospital of Philadelphia (CHOP) with an infection, which was subsequently identified as measles. The Philadelphia Department of Public Health considers the case to be "imported" but did not say from where.

The disease then spread to three other people at CHOP, two of whom were already hospitalized there for other reasons.

Two of those infected at the hospital were a parent and child. The child had not been vaccinated and the parent was offered medication usually given to unvaccinated people that can prevent infection after exposure to measles, but refused it, the Philadelphia Inquirer first reported.

Despite quarantine instructions, the child was sent to day care on Dec. 20 and 21, the health department said"

Philadelphia measles outbreak has hospitals on alert after child was sent to day care despite quarantine instructions​




 
Ozempic is a promising drug but it is just an adjunct, You still have to do diet exercise and lifestyle changes. Most medical studies have shown that when people stop taking Ozempic, without the lifestyle changes, they do gain weight back. People who take these drugs should enroll in programs that in addition to the drug, give you nutritional experts, lifestyle coaches and exercise regimens. They charge monthly for this program it is it is worth it because these are the people who lose the most weight and then actually keep it off.
.
 
The good news is that the pharmaceutical companies are making billions off of these drugs ,so they will keep refining it, this is only the first generation. Medical studies have shown that,in general, people are only 3 to 5% successful in changing their bad habits ,so hopefully future generations of this drug will help the rest. Sorry if this comes across as a lecture.
 
I worked in Pharma for 30+ years, but am pretty conservative in taking them. I only take a baby aspirin and low dose Crestor for lipids. While I know diet/exercise can be quite effective for some in addressing obesity, diabetes and even lipid levels, I have a hard part with the diet part, as I like the crappy foods I eat, lol, but I have made some changes towards more fruits/veggies and less refined foods. I've always been a bit active, but much moreso in retirement with ~30 min of exercise most days aimed at my various maladies (shoulder, knee, back/disc, feet, etc.) which I got from doing PT, and fairly vigorous walking most days playing disc golf or just walking with my wife, plus weekly soccer.

But we disagree somewhat on statins and significantly on herbal supplements. Statins are probably the best tested/evaluated drugs in history and the benefits are significant for most people, although there are side effects and diet/exercise can be effective too, so prescribing statins shouldn't be an automatic, just like prescribing Ozempic shouldn't me, IMO. Herbal supplements, in general, have never been evaluated in randomized controlled clinical trials and their manufacture is not subject to the rigors of FDA oversight, so their quality (active ingredients and contaminants) is not controlled like pharmaceuticals are. Berberine has not had the large scale RCTs conducted to firmly establish efficacy and patient safety - doesn't mean it's not possible it's helpful, but the data just aren't there yet.

I was working on a novel PCSK9 inhibitor (orally bioavailable) when I left Merck - it... started phase III trials earlier this year.

https://www.aafp.org/pubs/afp/afp-c...ks-rigorous-evidence-has-potential-harms.html
That link is hot trash. I hear ya on FDA regulated, but I have little faith left in the FDA. I had no idea about the Berberine fad, and I have several papers on studies in Europe and Asia showing the lipid lowering effectiveness of berberine. I'm keeping tabs ony blood work with my very good doc. The only bad effect I saw was that it interacts with some medicines I am not on.

Another side effect of statins is they can cause insulin resistant people towards diabetes. There are other possible side effects too. I may go to a pharmanPCSK9i down the road, and there is also the pro drug bempedoic acid, which is also expensive.
 
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That link is hot trash. I hear ya on FDA regulated, but I have little faith left in the FDA. I had no idea about the Berberine fad, and I have several papers on studies in Europe and Asia showing the lipid lowering effectiveness of berberine. I'm keeping tabs ony blood work with my very good doc. The only bad effect I saw was that it interacts with some medicines I am not on.

Another side effect of statins is they can cause insulin resistant people towards diabetes. There are other possible side effects too. I may go to a pharmanPCSK9i down the road, and there is also the pro drug bempedoic acid, which is also expensive.
Now you've done it, lol. C'mon, that link contains links to a number of primary scientific and small clinical studies done with berberine, so to call it "hot trash" is inaccurate. "Papers showing lipid lowering effectiveness" likely just means small pharmacokinetic studies, not RCTs assessing safety and efficacy. There are tons of molecules out there that are active on any number of clinical targets, but activity DOES NOT mean that molecule will be a safe and effective treatment - need the trials for that and as far as I can tell, they don't exist yet, but if you want to be a guinea pig, go for it. Not me. Especially with a supplement that is not regulated and of possibly dubious quality due to lack of regulatory oversight.
 
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Awesome. For some people it works. Have heard several stories that once a person stops taking the drug, it is hard to not go back to the old habits. Everyone is different, and if you can keep the weight off after going off the drug, that is a great accomplishment.
Yes, the TV networks did a recent dive on this and it's true that not only people go back to their old ways but on average they regain everything back plus 10%. Some people get a discount on the drug while prescribed for losing weight. At some point they lose the discount and it's very expensive. So they go off the meds and return to normal+.
 
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people need to just eat right and exercise but its too easy to eat unhealthy (and cheaper) and too many people would rather sit and look at their phones instead of even going for a walk.
I do think this is mostly true but there are definitely some people where they are just predisposed to being big. Just like some people stay skinny despite eating crap, people can have slower metabolisms as well as underlying conditions. But yes - hard to argue against eating better and exercise generally.
 
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I've always been on the slim side my whole life so never had issues with weight but I have tried to eat healthier and exercise more as I've gotten older. I'm not a trainer or psychologist or whatever but my thinking is you have to know your own psychology and figure out how to make things a habit. What makes you tick and what works for you and fits in your life. Once it's habit, it's hard to stop it, good habits are hard to break not just bad ones.

IMO one thing would be start small, however small, for exercise or food choices. Say 10 min walk a couple times a week or a vegetarian meal once a week to get more healthy stuff in your body. Do that for a couple months and then once its a habit (imo it takes 2-3 months for some thing to become a habit that's harder to break) build on it with another step or baby step. Once you get a sort of cycle going you can build with more steps and it's harder to break that habit even though the things you're doing might be "harder" than when you first started.

Another thing for me with regards to food is I don't ever feel I'm restricting myself or denying myself. I eat tons of healthy foods (fruits, veggies, nuts, grains etc..) daily and exercise daily so my thinking is I have a lot of check marks in the positive column on a daily basis so when I feel like eating something that might not be healthy or whatever, I eat it. This doesn't happen all the time but it does at times. I don't consider them cheat days or whatever, it's just I feel like eating that so I do lol. So I never feel like I've denied myself anything or restricted myself and so then it's easy to stick with all the other healthy things I do since I don't feel limited. That's my psychology and it makes it easier to make the positive habits a way of life. When it's a habit and a way of life, it will probably stick for the long haul.

Last suggestion is do these things with family or friends for camaraderie/support but not competition (unless that is part the participants psychology/motivation). The buddy system can be a helpful thing.

Just my 2 cents.
 
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