You're only further embarrassing yourself.
OT: COVID Science - Pfizer/Moderna vaccines >90% effective; Regeneron antibody cocktail looks very promising in phase II/III trial and more
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You're only further embarrassing yourself.
Wrong, COVID is in the phase 2/3 trial already. Did you take the time to scroll down to the bottom of the link? INO-COVID19 -4800 DNA vaccine production and scale up underway?https://www.inovio.com/our-focus-serving-patients/covid-19/
Which vaccine are you talking about? My point was Big Pharma doesn't want INO vaccine to see the light of day, geez.
With this- - - a small electric shock that opens the cell wall. Administration with the CELLECTRA® device ensures that the DNA medicine is efficiently delivered directly into the body's cells, where it can go to work to drive an immune response. INOVIO's DNA medicines do not interfere with or change in any way an individual's own DNA. The advantages of INOVIO's DNA medicine platform are how fast DNA medicines can be designed and manufactured; the stability of the products, which do not require freezing in storage and transport; and the robust immune response, safety profile, and tolerability that have been observed in clinical trials.
Easy dude. Read the top portion where it talked about MERS.
sounds exciting. When are phase 3 results expected?
Not sure, but it hasn't gotten the press it deserves, but overseas governments have already secured over $100 million worth of doses. Dr. Fauci is part of the problem since he's invested in the current vaccines and he tried twice to invest/develop a DNA based vaccine with no success. I don't think the man is worth my sweat off my nads.
So PA just confirmed their first case of this "new" strain. The first in the US was 10 days ago in Colorado. Yet there are only about 50 cases in the entire US and very spread out coast to coast. This is supposed to be a strain that is much more highly contagious. Has this been proven yet? Is what we are seeing here exactly the same as the UK version? Or just another of the many different strains that Covid has become?
It's whatever the media wants it to be, I'm afraid.
If I was in the UK I would be afraid. Here? Have no clue if this is the same thing.
So the media is saying it’s more highly contagious or is the media reporting on what the science says? Or too early to tell?
COVID Variants: What You Should Know
The new variants (originally called strains) raise questions: Are these coronaviruses more contagious? Will the vaccines still work? Are there different things you should do to keep safe?
Did you read anywhere that I assumed he didn't have another acute event at the same time he received this vaccine which would cause the severe thrombocytopenia? Because I never said that. I typically would not rule anything completely out unless I had definitive evidence leading me to a conclusion. If you can find another reason or cause for this reportedly healthy, 56 year old male which would cause a complete decimation of his platelets, I'm all ears. Remember, the reason has to be acute enough to destroy all of his blood cells in two days as he was presumably healthy with no preexisting conditions. Otherwise, the details I have read and the timing point to the administration of the vaccine.
Anyone have any tips on getting scheduled date for the vaccine? I am part of the 1A group in the medical field but it seems pretty difficult still...
Not sure if this has been mentioned already.
www.dailymail.co.uk
Anyone receiving Covid vaccine should AVOID alcohol, experts warn
Alcohol changes the make-up of the trillions of microorganisms that live in the gut which play an important role in preventing the invasion of bacteria and viruses.
This is a bridge too far!!!Not sure if this has been mentioned already.
Anyone receiving Covid vaccine should AVOID alcohol, experts warn
Alcohol changes the make-up of the trillions of microorganisms that live in the gut which play an important role in preventing the invasion of bacteria and viruses.
Phew, I read the article. I thought they were insinuating forever!!!
Quite simple to be on good behavior for a little while.
PCR tests do not test for any strain. The US's efforts to evaluate different circulating strains (which involves RNA sequencing, which is not trivial work) are far less comprehensive than the UK's or that of many other countries. This is the kind of thing that needs Federal leadership, like many other elements of pandemic prevention/response.
https://www.nytimes.com/2021/01/06/health/coronavirus-variant-tracking.html
That's behind a paywall for me. So are we basically spot checking samples then?
Initially it was reported a few weeks back by the BBC that the PCR tests "responded differently" to the new strain but that was probably bad reporting.
Why don’t you stick to posts that have some value instead of this nonsense.
wow. Hunterdon County/Somerset area has already moved into 1B group...police, firefighters, etc.
Have you gone to the NJ Covid Hub and registered for the Vaccine? take you 10 mins to answer some questions and I would assume you'd be a priority.
Just lost another cousin this afternoon. Like me he had asthma. He was doing great and it turned and took him in a matter of days.
I got several emails on Dec 15th saying I should be ready for mine in a few weeks. I guess it will be a few MORE weeks. Good luck to you.
Once again, aren't you the guy who last winter stated that we should not do anything because this is no worse than the flu - so only 35000 people or so would die from it? Now suddenly, you are worried about one life? Have you suddenly acquired new sensitivity to the human condition?
Reports up to this point have indicated all the people who had serious medical issues after getting the vaccine were people who were extremely sensitive to environmental allergens.
The companies administering these vaccines obviously have a lot at stake if issues arise, so they are analyzing any severe reactions to make sure they understand why they occur. In all the cases so far, getting an epinephrine injection or similar anti-allergic reaction medication has quelled the reaction. It is actually amazing that we have had so FEW severe reactions of any kind to the vaccines so far.
Every death is important, The fact though is that we are now losing 4000 people every day, so one or two deaths among 20 million vaccine injections may be a price that has to be paid to overcome this virus.
It is true we have not had enough time yet to determine any long term detrimental effects. However, due to the nature of the vaccine (relatively small pieces of RNA), the odds of long term negative effects are probably less than the odds of getting killed by a train.
As for this guy ....2008, he throws around what sounds like technical language in a manner that makes no sense. Some of us are aware what all the terms that he drops mean, but I is pretty obvious he doesn't because of the way he combines them. It is clear he does not even understand what a T-cell is or how it works.
No never said..you are talking about someone else
Question is why are coming in thread bold face lying about i what i said
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Enough? Get back to me when we are vaccinating over 1.5 million a day. Otherwise cancel your Thanksgiving plans again.
I've been hoping since Pfizer first doses have been shipped. A long, a very uncomfortable long way to go.
I know we’ve debated this but I think there will be a much more concerted effort at the top which will help. We are already seeing a different game plan. Hope they have enough insight into the supply plan to sequence the doses.
Update on SARS-CoV-2 variants and vaccines. Preliminary work shows that the Pfizer/BioNTech vaccine will very likely still be effective against both the UK and South Africa variants that are circulating and appear to be more transmissible (more work remains to be 100% sure on this). And even if we eventually see variants that "escape" the vaccine, modifying the RNA sequence used in the mRNA vaccines to provide effectiveness for new strains, should only take 6-12 weeks (it would take longer in other vaccines that use viral vectors to deliver the RNA; same for protein-based vaccines). It's still likely that vaccine immunity will last a few to several years, barring many more major mutations than we've seen to date (which should take years given the fairly slow evolution rate of this virus).
https://apnews.com/article/pfizer-study-vaccine-coronavirus-strain-3094dd3cc91b4a20780402476cdcb5ae
In addition, work was done with the UK and South African variants and polyclonal antibodies from convalescent patients (infected with COVID and recovered) and this work showed the antibodies generally neutralized the UK variant, but had some reduced neutralization of the SA variant, which has an additional mutation (E484K, an amino acid on the spike protein of the virus) the UK variant does not have. However, immune responses from the vaccine are more robust and broader, so the authors of this study said that they didn't think this variant would have a serious effect on vaccine efficacy - and that further mutations over time would likely be needed to erode vaccine immunity.
“I’m quite optimistic that even with these mutations, immunity is not going to suddenly fail on us,” Bloom said. “It might be gradually eroded, but it’s not going to fail on us, at least in the short term.”
https://www.statnews.com/2021/01/07/coronavirus-mutation-vaccine-strength/
Having said all of the above, this is why getting the world vaccinated fairly quickly, especially those countries with high infection rates is so important, since evolutionary changes are far more likely when more people are being infected (just rolling the dice more). What would also suck is if the virus were largely eliminated from a bunch of countries, but then a new variant that somewhat or even largely escapes the vaccines (since they're all targeting the spike protein, although not 100% identically, so eluding all of them is unlikely) developed elsewhere and started infecting vaccinated people. That's why vigilance on strains and immune responses to those strains induced by vaccines are so important to identify quickly to allow modified vaccines to be developed quickly.
https://www.reuters.com/article/hea...against-new-coronavirus-variant-idUSKBN28W1P5
Wait, are you telling me they don't have it all figured out? Oh crap, another year of social distancing and ordering in. I thought all our problems were about to go away. Praying for Inovio
Genetic Variants May Lead to False Negatives with SARS-CoV-2 Molecular
Laboratories should expect some false negative results because the SARS-CoV-2 virus can mutate over time and not be detected.
something new I've been recently seeing is positive antigen tests and false negative PCR related to above...particularly TaqPath. My own obtained samples all go to LabCorp or Quest - now with quick tat.
fyi had my vax just after Christmas day...had very strange side effect (waited for Moderna on purpose). Been walking around with a sustained erection since getting vax. Very unusual.
Kidding aside, I had such a nonreaction that im concerned i got saline. will expect a bit more something in a couple weeks on booster. I also suspect the rollout is going to be accelerating from here on out. Received email yesterday allowing ordering for my NJ office. At first they wanted to inspect my cold storage chain but they seemingly punted on that. i do have to get a new digital data logger. Obviously not dealing with Pfizer.
Genetic Variants May Lead to False Negatives with SARS-CoV-2 Molecular
Laboratories should expect some false negative results because the SARS-CoV-2 virus can mutate over time and not be detected.www.fda.gov
something new I've been recently seeing is positive antigen tests and false negative PCR related to above...particularly TaqPath. My own obtained samples all go to LabCorp or Quest - now with quick tat.
fyi had my vax just after Christmas day...had very strange side effect (waited for Moderna on purpose). Been walking around with a sustained erection since getting vax. Very unusual.
Kidding aside, I had such a nonreaction that im concerned i got saline. will expect a bit more something in a couple weeks on booster. I also suspect the rollout is going to be accelerating from here on out. Received email yesterday allowing ordering for my NJ office. At first they wanted to inspect my cold storage chain but they seemingly punted on that. i do have to get a new digital data logger. Obviously not dealing with Pfizer.
😂 had me for a second
From The Economist
GOOD NEWS from covid-19 wards is hard to come by these days. A relentless surge in infections is overwhelming hospitals around the world. But the results from clinical trials of two drugs announced today just improved the prognosis, for both patients and hospitals.
The two drugs, called tocilizumab and sarilumab, are currently used to reduce inflammation in patients with arthritis. Hyper-inflammation, whereby the immune system goes into overdrive and destroys the organs, is how covid-19 tends to kill. The search for suitable anti-inflammatory drugs for covid-19 has already turned up one, dexamethasone. It is a cheap steroid that dampens the immune system across the board. In contrast, tocilizumab and sarilumab are more targeted. They are both made of antibodies that block the effect of interleukin-6, a protein that stokes the immune response and has been prominent in patients with covid-19.
GOOD NEWS from covid-19 wards is hard to come by these days. A relentless surge in infections is overwhelming hospitals around the world. But the results from clinical trials of two drugs announced today just improved the prognosis, for both patients and hospitals.
The two drugs, called tocilizumab and sarilumab, are currently used to reduce inflammation in patients with arthritis. Hyper-inflammation, whereby the immune system goes into overdrive and destroys the organs, is how covid-19 tends to kill. The search for suitable anti-inflammatory drugs for covid-19 has already turned up one, dexamethasone. It is a cheap steroid that dampens the immune system across the board. In contrast, tocilizumab and sarilumab are more targeted. They are both made of antibodies that block the effect of interleukin-6, a protein that stokes the immune response and has been prominent in patients with covid-19.
Saw that too. Think this was a UK study though, I wonder what the fda’s stance of this is.
Even with a vaccine I really want there to be successful treatments
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