You do know he contradicted Trump's false claims all the time. He was banned from the White House and rumors of being fired by Trump numerous times.
OT: COVID Science - Pfizer/Moderna vaccines >90% effective; Regeneron antibody cocktail looks very promising in phase II/III trial and more
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Sometimes leadership means not taking suicidal action. If he spoke out too strongly he would have been removed or put on ice even more than he was.
If you were the General in command of a Division and you attempted to plan the battles for each one of your brigade comanders they would court marshal you.
50 state Governors should be smart enough to figure this out.
Some how West Virginia did
The assumption many are making is that the Federal Government had no control once the vaccine made it to each state. That is completely false. The Federal Government could have had complete control. They elected not to.
Umm it’s coordinated from the top and the resources are marshaled and dispersed from the top. Reinforcements, air support etc.
Fail
Not that i had heard this... But had heard suilence on Merck vaccine possibillities months ago
I don't want to clutter this thread up with discussion that have to do with the vaccine and treatments so we can move this to the CE board. I already started a thread there about how a state with a $40 Billion dollar budget is unable to setup a proper distribution network or even set up an an appointment system. We can discuss military planning their also.
RU#'s - this might be a stupid question, but if it is, I'm confident that you will answer it respectfully! :-) Does Merck have any vaccine manufacturing capacity that another COVID-19 vaccine manufacturer would be able to rent from them to get more doses of the, say, Pfizer or Moderna vaccines to market? Or, if the mRNA is so different than traditional vaccines, maybe the J&J vaccine if/when it gets approved?
This is a Hail Mary but I figured that I would ask.
It's a good question, which was discussed months ago, but I don't recall Merck ever saying anything publicly about it. I would think Merck could supply manufacturing capacity for others, but I don't know that it would come on line fast enough to make much of a difference in the US, where we should have enough vaccine doses for everyone who wants one by this summer (assuming J&J comes through); it could make a difference for the rest of the world, however. Maybe @newell138 knows more, as he's in the vaccine manufacturing area (I'm not). I may also ask around as I've been curious about this one too (although it's possible things are going on I don't know about, as MK is very tight with that kind of info normally, even internally).
Last thing I want to do is waste my time on that board debating facts and fake news when most there cannot even discern between the two.I don't want to clutter this thread up with discussion that have to do with the vaccine and treatments so we can move this to the CE board. I already started a thread there about how a state with a $40 Billion dollar budget is unable to setup a proper distribution network or even set up an an appointment system. We can discuss military planning their also.
a states budget is designated for certain things and isn’t a slush fund to use on other things. Covid and vaccines require resources. The federal government is uniquely qualified to provide those resources given its virtual unlimited spending authority as well as its pressure it can bring to bear on private enterprises.
thisisn’t even debatable and should be widely understood.
last thing I will say is that there is no difference between red and blue State roll outs. And please stop saying there is. The datas clear and More importantly it doesn’t matter.
Funny that you ask because there was a rumor floating around yesterday that we may possibly be doing some of the packaging for J&J. If true we will know soon, either the new line we were planning for covid is going up or its not.
BTW, if anyone is looking for an entry level job in supply chain we have a couple openings in our department at Lansdale, PA
Another question for both of you...
Is it all being made here? The reason I ask is that I got a memo the other day at work referencing a fire in an assembly plant in India that is making the vaccine.
Oxford/AstraZeneca vaccine which is mostly manufactured for the rest of the world for right now.
The fire in India is not J&J or any other American co. to my understanding its an Indian pharma co. IDK if you want any of what they are making anyway. I am hearing the Chinese and Indian version of the covid vaccine have less immune response than the 2 Merck just scrapped.
We are continuing work on the new packaging line so the J&J rumor may be true
Americans seem to ignore what the rest of the world is doing some times. This is one of those cases. Currently there are a total of 9 vaccines approved and being used worldwide.
You make assumptions , I said nothing of red state and blue state. I pointed out West Virginia having success because of smart management and a knowledge of their state make up.
The remainder of my comments here (no more replies here).
You make assumptions , I said nothing of red state and blue state. I pointed out West Virginia having success because of smart management and a knowledge of their state make up.
The remainder of my comments here (no more replies here).
The state also opted out of a federal partnership to administer vaccines to long-term care residents and staff, working instead with local pharmacies. West Virginia decided to not use CVS and Walgreens, a Warp speed federal program, for their LTC vaccines. NJ should have opted out of that program.
Why West Virginia's Winning The Race To Get COVID-19 Vaccine Into Arms
To get vaccines into long-term care facilities, West Virginia was the only state to opt out of a federal partnership with CVS and Walgreens. Instead, a network of smaller pharmacies got a jump-start.
www.npr.org
For one thing, West Virginia has been charting its own path to vaccine distribution. All 49 other states signed on with a federal program partnering with CVS and Walgreens to vaccinate long-term care and assisted living facilities. But those chain stores are less common in West Virginia, so the state instead took charge of delivering its vaccine supply to 250 pharmacies — most of them small, independent stores.
Israel has closed its airspace as a result of the new strains and now Angela Merkel says Germany will follow suit. This seems pretty drastic considering current vaccines do have an effect against the new strains and there still isn't irrefutable peer-reviewed proof these new strains are more transmissible (last I checked, at least).
A lot of good news on the mABs the last couple days. They work very well as a prophylactic. And the Regeneron one can be administered via subcutaneous injection, so no need for an IV or anything.
Too bad supply is scarce and it’s so expensive to make.
investor.regeneron.com
Lilly had similar results in their mAB combo cocktail, but don’t think it can be as easy administered.
Too bad supply is scarce and it’s so expensive to make.
Regeneron Reports Positive Interim Data with REGEN-COV™ Antibody Cocktail used as Passive Vaccine to Prevent COVID-19 | Regeneron Pharmaceuticals Inc.
TARRYTOWN, N.Y. , Jan. 26, 2021 /PRNewswire/ -- Reduction in overall infections seen within first week, with 100% prevention of symptomatic infections Markedly decreased levels and duration of viral shedding in asymptomatic infections that still occurred in REGEN-COV group Confirmatory Phase 3
investor.regeneron.com
Lilly had similar results in their mAB combo cocktail, but don’t think it can be as easy administered.
More good news. Pfizer getting us 200M doses by end of April. They pushed their timeline up by 2 months somehow.
If J&J works we’ll have enough doses to vaccinate anyone who wants it by April. We’ll be close to that even without J&J!
Bloomberg - Are you a robot?
www.bloomberg.com
If J&J works we’ll have enough doses to vaccinate anyone who wants it by April. We’ll be close to that even without J&J!
I'll believe it when I see it. They have made many false promises about production from the beginning. 200 million doses is vaccinating 100 million people twice. No way that gets done by the end of April.
Please oh Pointy God Vaccus, patron of the vaccine arts, make this be true.
The only thing I know about it is its a 1 shot deal instead of the 2 like what we currently have
Another excellent survey of the vaccine landscape by Derek Lowe in his In The Pipeline blog for ScienceMag. He hits all the categories and all the major players. Talks about the Merck vaccine failure (but has a nugget that Merck IAVI are still going to try a different route of administration, as they suspect the intra-muscular route may have been a problem) and has updates on J&J (phase III data any day now on the one dose protocol), Astra-Zeneca, and Novavax, as well as reports on how well the mRNA vaccines from Pfizer and Moderna are doing (medically, not distribution). He also highlights lesser known efforts from about a dozen other outfits. Worth a read.
https://blogs.sciencemag.org/pipeline/archives/2021/01/25/vaccine-roundup-merck-wipes-out-and-more
A little more on Pfizer getting more doses. They did this by changing the label.
Chief Executive Officer Albert Bourla said Tuesday that the drugmaker and its partner, BioNTech SE, will be able to deliver more doses to the U.S. and European Union before the end of the second quarter due to a change in the vaccine’s label that allows health-care providers to extract an additional dose from each vial.
Here you go. The site's search functionality is decent - took 5 seconds to find my post above - phase III data on the single shot protocol are expected any day now and if good (immune responses in healthy volunteers were pretty good, so it's likely to be good, although maybe not quite as effective as the mRNA vaccines), we should expect an EUA (emergency use authorization) by late February.
Not sure if that’s the sole reason. I guess the question is, can they actually get 6 doses or not? If that’s true, than the label change is justified and 6 doses is 6 doses.
More good news from the monoclonal antibody cocktails. Eli Lilly reported results from a large phase III trial (1035 patients) in recently infected high risk patients using their combo of 2 mAbs (they've mostly been using just one of them so far) showing a 70% reduction in hospitalizations and deaths in these high risk patients. Every reason to believe that the Regeneron cocktail would be similarly effective (data pending soon).
https://medicalxpress.com/news/2021-01-lilly-covid-antibodies-hospitalizations-deaths.html
Also, Regeneron announced that their cocktail was effective as a "passive vaccine" with a 50% reduction (400 patient trial) in preventing infections and 100% effectiveness in lessening severity of infection in those who become infected.
https://www.nbcnews.com/health/heal...ive-preventing-covid-19-company-says-n1255667
https://medicalxpress.com/news/2021-01-lilly-covid-antibodies-hospitalizations-deaths.html
Also, Regeneron announced that their cocktail was effective as a "passive vaccine" with a 50% reduction (400 patient trial) in preventing infections and 100% effectiveness in lessening severity of infection in those who become infected.
https://www.nbcnews.com/health/heal...ive-preventing-covid-19-company-says-n1255667
The analogy is just stupid. We understand you hate allowing state's rights and all but planning done locally is almost always better. A top down blanket roll out probably wouldn't have worked any better.
all that would have done was make it easier for the states to blame the feds for all failures which adds to the polarized country as the msm would create more hysteria. There was plenty of time for states to work and put plans in place. You see some states are accomplishing this and others are not.
What about CT or VT or even Puerto Rico? NJ is toward the upper end of states administering what they have. As others have pointed out WV did not follow the senior pop guidelines so an easier early administration.You make assumptions , I said nothing of red state and blue state. I pointed out West Virginia having success because of smart management and a knowledge of their state make up.
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Umm no. I just don’t think things should be left up to them when it comes to things that require national policy like defense and a global pandemic. You know the virus doesn’t see state borders.
We need both and both the Federal and State efforts have been weak so far, especially on the Fed side, particularly with regard to knowing vaccine doses vs. time and where they're going, plus there was very little funding for the states to put the local programs together that are needed to do the day-to-day work. I also think there's no doubt a very motivated/integrated Federal program, utlizing the military and modern health care data systems would be best - that's what they have in Israel (posted on this a few days ago), where over 30% have been vaccinated already - of course part of that is them successfully procuring a higher % of doses than others have, but they've also been able to deliver almost all of their doses.
The last round of stimulus provided $9 Billion in vaccine distribution funding
Covid relief bill includes about $8 billion for vaccine distribution
The Covid-19 relief package agreed to by lawmakers provides for more funding for coronavirus vaccine distribution than did earlier proposals.
The funding appears to exceed the $6 billion target set by the Trump administration and may meet the demand made by national organizations representing local public health officials, who have said that at least $8.4 billion was required to carry out the massive vaccination campaign.
Hard to say without the data. Need to know prevention of symptoms and prevention of severe disease/deaths (as well as any side effects, which are not expected to be an issue) for the comparison with the two mRNA vaccines, which are nearly identical. If it's 80% or more effective in preventing symptoms, with no severe cases, I think it might become the vaccine of choice, given the single shot and milder storage conditions (refrigeration only). If it's only 70% effective and there are even a few severe cases, my guess is it might become a secondary vaccine, at least in the US, where the other two will likely be available in high numbers by late spring.
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