I guess it depends on what you're looking for. Agree with all of the higher end type places:
Catherine Lombardi
Clydz
Stage Left
Frog and the Peach
Steakhouse 85
Due Mare
Others more on the casual side:
Evelyn's (Lebanese/Middle Eastern- there's a new place next to it that I haven't tried yet- City something?)
Destination Dogs
George Street Ale House
Harvest Moon (brewpub)
World of Beer (not a huge menu, but good beers on tap)
Old Bay (food was better during a recent visit, solid tap list)
Stuff Yer Face (I have to list it, home of the Boli!)
Dillinger's Tap Room ? (opened where Hotoke used to be, haven't tried it yet)
Glasswood's Tavern at the Hyatt
Christopher's at the Heldrich
Old Man Rafferty's
Tumulty's
A little outside of town on Hamilton in Somerset:
Sophie's Bistro