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COVID-19 Pandemic: Transmissions, Deaths, Treatments, Vaccines, Interventions and More...

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Thanks for both of your replies. I was reading a treatment protocol that was put out by a hospital system down in Virginia (can't remember which one) and they were talking about liberal use of anticoagulants. Also mentioned vitamin C, zinc, HCQ, zith, steroids...I'll have to see if I can find it. This disease is horrifying and fascinating at the same time.

Here's the treatment protocol I'm referring to. Would be interesting to know how this compares to what is being done at your hospitals.

https://www.evms.edu/media/evms_pub...cine/EVMS_Critical_Care_COVID-19_Protocol.pdf
Thank you for sharing. Ironically, a week ago started taking Quercetin 250mg BID along with eating more zinc rich foods in my diet. Also, for those interested quercetin is a zinc ionophore, i.e., helps transport zinc across cell membranes.

https://www.healthline.com/nutrition/best-foods-high-in-zinc
 
Thank you for sharing. Ironically, a week ago started taking Quercetin 250mg BID along with eating more zinc rich foods in my diet. Also, for those interested quercetin is a zinc ionophore, i.e., helps transport zinc across cell membranes.

https://www.healthline.com/nutrition/best-foods-high-in-zinc
I remember hearing about quercetin a while back. Have you done any research on it, so that you can recommend specific brands or formulations? I know for some supplements it matters what type of preparation or source is used (for instance there are different formulations of vit D).
 
I remember hearing about quercetin a while back. Have you done any research on it, so that you can recommend specific brands or formulations? I know for some supplements it matters what type of preparation or source is used (for instance there are different formulations of vit D).
Quercetin dihydrate with Bromelain. I got mine at my local The Vitamin Shoppe. Bromelain helps with absorption. On a side note, my allergies have improved since taking it...yay.

https://www.healthline.com/nutrition/quercetin#what-it-is

I am not sure but I vaguely remember that quercetin in apples is in the skin so you might want to check and if so eat skin too.

https://regenexx.com/blog/coronavirus-episode-9-can-quercetin-help-covid-19/
 
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Thanks for both of your replies. I was reading a treatment protocol that was put out by a hospital system down in Virginia (can't remember which one) and they were talking about liberal use of anticoagulants. Also mentioned vitamin C, zinc, HCQ, zith, steroids...I'll have to see if I can find it. This disease is horrifying and fascinating at the same time.

Here's the treatment protocol I'm referring to. Would be interesting to know how this compares to what is being done at your hospitals.

https://www.evms.edu/media/evms_pub...cine/EVMS_Critical_Care_COVID-19_Protocol.pdf

We arent using anticoagulants as liberally as is described. Admitting anything over 4L/min to ICU and daily echocardiograms are great ideas, but if/when they get busy and fill up unit, after unit, after unit, they will need to rethink that protocol as it is just not feasible.
 
And now the WHO director is alleging the Taiwanese made racist comments about him:

Coronavirus: WHO chief and Taiwan in row over 'racist' comments
Terdro needs to go
NY has a massive subway system. LA doesn't. NYC population density 26403 ppl per square mile. LA 7545 ppl per square mile. NJ has a lot of people commuting to the city on trains. LA is a car city.

I bet that has a lot to do with it too in addition to starting a week earlier on shutting things down.
The population density of NYC and most areas in N.J. is far greater than California by far... as populated as California is we are for the most part living right on top of each other... Just look at the 50 mile radius around us...I think both Murphy and Cuomo have done a good job ...Di Blasio not so much so ... Di Blasio waited too long ... he is a poor manager who neglected to enforce restrictions on a city where it could have been life saving... the guy is a political hack.
 
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I hope our medical folks are learning as these folks have:

April 9th entry (still top of page as of now) and listen to the first podcast. Got 1:35 mark of first podcast and listen to an expert from Italy. Rushing to ventilators was wrong treatment and many lives were lost. Treatment should be the opposite...i.e, do everything to avoid ventilation unless absolutely necessary.
https://thinkingcriticalcare.com/
 
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I hope our medical folks are learning as these folks have:

April 9th entry (still top of page as of now) and listen to the first podcast. Got 1:35 mark of first podcast and listen to an expert from Italy. Rushing to ventilators was wrong treatment and many lives were lost. Treatment should be the opposite...i.e, do everything to avoid ventilation unless absolutely necessary.
https://thinkingcriticalcare.com/
That is consistent with what I've been reading and is what is stated in the treatment protocol from the Norfolk Va area hospital. It must be tough though when the ERs and ICUs get overwhelmed and there isn't enough time/manpower to do much other than intubate and move on to the next person.
 
I just wanted to emphasize a point that I think has been mentioned here: that we shouldn't be hugely influenced by the leveling off of new cases. That may just reflect the practical limits on how many patients can be tested each day. We really need the 15-minute test (done by Abbott, I believe) to work and to be rolled out quickly.
 
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Quercetin dihydrate with Bromelain. I got mine at my local The Vitamin Shoppe. Bromelain helps with absorption. On a side note, my allergies have improved since taking it...yay.

https://www.healthline.com/nutrition/quercetin#what-it-is

I am not sure but I vaguely remember that quercetin in apples is in the skin so you might want to check and if so eat skin too.

https://regenexx.com/blog/coronavirus-episode-9-can-quercetin-help-covid-19/
Good to know. Generally like to get as many vitamins/minerals from foods rather than supplements with some exceptions...especially if it's not a brand I trust or am familiar with because I don't think the supplement industry is that well regulated IIRC.

Have 1-1.5 apples with skin as part of my daily smoothie. Never heard of quercetin but always kept the skin on because that's the most nutrient part of the apple I've read and has the flavonols in it. Like they say "an apple a day keeps the dr. away" and this case like never before that's a good thing.
 
I just wanted to emphasize a point that I think has been mentioned here: that we shouldn't be hugely influenced by the leveling off of new cases. That may just reflect the practical limits on how many patients can be tested each day. We really need the 15-minute test (done by Abbott, I believe) to work and to be rolled out quickly.
Yep, testing is questionable but we should see a leveling off of the number of people winding up in the ICU, on ventilators, etc. Seems like that is happening in NYC at least...hopeful.
 
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Terdro needs to go

The population density of NYC and most areas in N.J. is far greater than California by far... as populated as California is we are for the most part living right on top of each other... Just look at the 50 mile radius around us...I think both Murphy and Cuomo have done a good job ...Di Blasio not so much so ... Di Blasio waited too long ... he is a poor manager who neglected to enforce restrictions on a city where it could have been life saving... the guy is a political hack.
DiBlasio looks very bad because his encouraging of the chinese celebration looks to be a political reaction to Trump's chinese travel ban.

But despite the travel ban there was very much a down playing of the situation from the federal gov't. I have to believe DiBlasio was not being given information from the fed's that said this is a serious issue. And if they were giving him that information, and he was going to ignore it, the fed's should have stepped in.

I think it is hard to pin the blame on a mayor for not having proper information regarding a pandemic that was at that time, was primarily in China.
 
I just wanted to emphasize a point that I think has been mentioned here: that we shouldn't be hugely influenced by the leveling off of new cases. That may just reflect the practical limits on how many patients can be tested each day. We really need the 15-minute test (done by Abbott, I believe) to work and to be rolled out quickly.
I think the social distancing practices is clearly showing results in NYC.

Question is how long before we can open things up without there being a major spike.
 
I think the social distancing practices is clearly showing results in NYC.

Question is how long before we can open things up without there being a major spike.

Again, that depends on how seriously you take the numbers. I think what is happening is that the system has simply reached capacity on diagnosing new cases.
 
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DiBlasio looks very bad because his encouraging of the chinese celebration looks to be a political reaction to Trump's chinese travel ban.

But despite the travel ban there was very much a down playing of the situation from the federal gov't. I have to believe DiBlasio was not being given information from the fed's that said this is a serious issue. And if they were giving him that information, and he was going to ignore it, the fed's should have stepped in.

I think it is hard to pin the blame on a mayor for not having proper information regarding a pandemic that was at that time, was primarily in China.
Di Blasio is a hack... the fact remains that as the mayor in one of the largest cities in the world he should have erred on the side of caution...he didn’t... even after issuing his emergency edict he allowed large groups to congregate and mingle together... Kumbaya attitude... for someone who claims to be such a proponent of the working poor mayor Di Blasio is only a paper tiger in reality... truth be told he only got elected because nobody came out to vote ...
 
DiBlasio looks very bad because his encouraging of the chinese celebration looks to be a political reaction to Trump's chinese travel ban.

But despite the travel ban there was very much a down playing of the situation from the federal gov't. I have to believe DiBlasio was not being given information from the fed's that said this is a serious issue. And if they were giving him that information, and he was going to ignore it, the fed's should have stepped in.

I think it is hard to pin the blame on a mayor for not having proper information regarding a pandemic that was at that time, was primarily in China.

The City belongs to the State, not the Feds. It would be Cuomo's duty to step in, NY State has much more legal pull over NYC than the Fed.
 
Again, that depends on how seriously you take the numbers. I think what is happening is that the system has simply reached capacity on diagnosing new cases.
It's a good point. There were posts recently that even said in NJ, still, they're reporting cases / test results from 7 days ago.
 
Great article on the behind the scenes efforts to get the convalescent plasma-antibody approach moving over the last coupl, where blood plasma from infected, but recovered patients containing antibodies to the virus are infused into patients with the virus - it's been very promising in very small studies in China so far and we should know a ton more in about 2-3 weeks.


Great article on the behind the scenes efforts to get the convalescent plasma-antibody approach moving over the last couple of months, as doctors and researchers work around the clock to develop the science and clinical protocols to evaluate this treatment technology. If this ends up being as effective as many think it will be, Dr. Arturo Casadevall will be taking home the Nobel Prize in Medicine for his work to make the pitch to get this on the radar of the medical community and public health leaders and his efforts to marshall the far flung forces required to bring this from concept to a scalable treatment for at least tens of thousands, so that death is no longer a common outcome from this virus. According to the article we should know how it works in larger scale trials by late April. Crossing fingers as humanity could use a break here.

"Arturo Casadevall and collaborators at Johns Hopkins and beyond have worked around the clock to develop a convalescent serum therapy to treat COVID-19 using blood plasma from recovered patients. If early promising studies on the therapy done in China are confirmed by U.S. trials, thousands of survivors might soon line up to donate their antibody-rich plasma. "I absolutely think this could be the best treatment we have for the next few months," Hopkins pathologist Aaron Tobian says."

https://hub.jhu.edu/2020/04/08/arturo-casadevall-blood-sera-profile/

There are many challenges for the use of serum transfer. Among them is that detectable neutralizing antibodies to coronaviruses do not last long past resolution of the infection. Neutralizing antibodies (these are antibodies that bind to the virus and either block its entry into cells or cause its destruction) waned as fast as 4 months in people with SARS-CoV-1 infections.

Furthermore, a really nice pre-print study (which has not yet been peer reviewed) from Shanghai, shows that ~30% of recovered people (N=275) did not have detectable levels of neutralizing antibodies. I was very surprised and worried to see these data.

If verified, these results not only impact serum transfer efforts, but also might not be protected from reinfection. But please understand, neutralizing antibody concentrations are only one of several factors that protect people from reinfection, so don't freak out.

If these data are verified, it also might mean that a serological test (which tests for antibodies against the virus to show who has previously been injected) might have a very high error rate. Again, there are caveats to this.

Here's the link for those who like to read primary scientific literature: https://www.medrxiv.org/content/10.1101/2020.03.30.20047365v1
 



Apple and Google working together to develop a solution to alert you if you come in contact with someone who has tested positive for COVID-19. Will be Bluetooth short range tracking and opt-in only. Expect to hear a lot about this and "Contact Tracing" in the coming months and many debates about the privacy and security concerns that come with it.

Announcement: https://blog.google/inside-google/c...e-partner-covid-19-contact-tracing-technology
Whitepaper: https://blog.google/documents/58/Contact_Tracing_-_Bluetooth_Specification_v1.1_RYGZbKW.pdf
High Level Slides: https://blog.google/documents/57/Overview_of_COVID-19_Contact_Tracing_Using_BLE.pdf
 
Unfortunately I'm both in and out of hospital but I have to tell you the nurses are doing the yeoman's work. We limit the The amount of people going in and out of the room and use the nurse as an arm.
The sick patients are not behaving like typical ARDS and their lung s are fairly flexible but they're requiring a ridiculous amount of what we call peep which is probably damaging their lungs. I think it's going to turn out to be more like what we call high altitude pulmonary edema. Keeping the patient on their belly especially if they're overweight half the day is now the protocol. One of the troubles is the truly ill patients are hypercoagulable and I think eventually we're just going to put everybody on standard anticoagulation because they all look like they have pulmonary emboli even as outpatients. So we want to keep the lungs as dry as possible because those alveoli , air sacs are drowning and some hospitals are using Lasix drips but we need to maintain blood pressure and perfusion to other areas so it's a double-edged sword. I had a lady 2 days ago who was improving greatly at home on day 15 and then she started getting chest pain again which I swore she had to develop a pulmonary embolus and sent her d-dimer which was off the wall And I was dreading calling her back but when she answered the phone she was like I'm great It's all gone I feel better so I'm crossing my fingers. And we can't keep testing them because we don't want to expose radiology and ultrasound people just for the sake of testing. I've never seen these kind of inflammatory numbers and hyper coagulation numbers this far out so the two week thing is so arbitrary. I really think our best that is to use the meds that will interfere with the cytokine storm because this reminds me of how some young healthy people react to the equipment when they're in open heart bypass surgery and they have such rocky roads because their immune systems are reacting to the materials like the tubing of the bypass machine. it seems like it's a two-phase illness where you have the initial infection which doesn't seem like too big of a deal and then the immunological part which is causing the most problem.


One more thing I have to add and this is anecdotally driven.
I have had people who I have put on zithromax alone And I absolutely hate doing this for a variety of reasons. And overnight their pulse ox went from '80s to '90s with them feeling improved. I don't know what to make of it but the other day I have this construction company guy who's been at home with his elderly demented ill mother and her caretaker who's also ill and he had gone to medi merge and was given some cough medication and for some reason Biaxin. They didn't covid test him.
So he's deteriorating and And he has a history of coronary disease and MI so I'm avoiding plaquenil. chest x-ray shows peripheral bilateral pneumonia pretty typical and his labs aren't too terrible yet and I switch him to zithromax and he's dancing the next day (And now I've done this multiple times) Hope I didn't just jinx myself and him. So, I'm now wtf. I'm going to give it early but we're on strict watchdog regarding the plaquenil.
I'm surprised i haven't heard the pulmonary edema comparison more. That's a good one. Also, do you dial up the PEEP to minimize the pressure support? It must be a difficult challenge finding the sweet spot with so much pathophysiology this disorder brings.
 
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DiBlasio looks very bad because his encouraging of the chinese celebration looks to be a political reaction to Trump's chinese travel ban.

But despite the travel ban there was very much a down playing of the situation from the federal gov't. I have to believe DiBlasio was not being given information from the fed's that said this is a serious issue. And if they were giving him that information, and he was going to ignore it, the fed's should have stepped in.

I think it is hard to pin the blame on a mayor for not having proper information regarding a pandemic that was at that time, was primarily in China.

What travel ban? 430,000 travelled to and from China since Trump’s January 31st travel ban.

https://www.nytimes.com/2020/04/04/us/coronavirus-china-travel-restrictions.html
 
Ya, the way I heard it, it was a law.

Although today we got a call from the police that anyone in the store must wear masks. Don't know if my town implemented something or if they also were going off half info.



Apple and Google working together to develop a solution to alert you if you come in contact with someone who has tested positive for COVID-19. Will be Bluetooth short range tracking and opt-in only. Expect to hear a lot about this and "Contact Tracing" in the coming months and many debates about the privacy and security concerns that come with it.

Announcement: https://blog.google/inside-google/c...e-partner-covid-19-contact-tracing-technology
Whitepaper: https://blog.google/documents/58/Contact_Tracing_-_Bluetooth_Specification_v1.1_RYGZbKW.pdf
High Level Slides: https://blog.google/documents/57/Overview_of_COVID-19_Contact_Tracing_Using_BLE.pdf
I read an article about this and it seemed like it was an opt-in app. If that's true there isn't a privacy issue.
 
I am interested in this study for fighting CV19:

https://www.biospace.com/article/re...cal-trial-of-apn01-for-treatment-of-covid-19/

APN01 is a recombinant human Angiotensin Converting Enzyme 2 (rhACE2) and was developed by APEIRON biologics for the treatment of acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and pulmonary arterial hypertension (PAH). After licensing from APEIRON in February 2010, GlaxoSmithKline (GSK) conducted several clinical trials from 2014 to 2017 to treat ALI/ARDS and PAH patients, lung injury being the major source of Covid-2019 mortalities, the disease caused by the new corona virus SARS-CoV-2. In 2019, APEIRON obtained the APN01 licenses back from GSK for further clinical development, after a their strategic refocusing of GSK to oncology.

The ACE2 receptor is expressed in human airway epithelia as well as lung parenchyma and was previously identified as the essential gateway used by the first SARS-CoV virus to infect human cells. ACE2 is also the critical receptor for the new virus SARS-CoV-2 to enter human cells. Thus, treatment with recombinant human ACE2 could be used to not only block viremia but also protect lungs and other organs from injury. The drug candidate is administered intravenously as an infusion and has already shown safety and tolerability in 89 patients and volunteers.
 
The City belongs to the State, not the Feds. It would be Cuomo's duty to step in, NY State has much more legal pull over NYC than the Fed.
The state's also don't have the international intel to know.

This is a federal issue.

War time and all that.
 
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Di Blasio is a hack... the fact remains that as the mayor in one of the largest cities in the world he should have erred on the side of caution...he didn’t... even after issuing his emergency edict he allowed large groups to congregate and mingle together... Kumbaya attitude... for someone who claims to be such a proponent of the working poor mayor Di Blasio is only a paper tiger in reality... truth be told he only got elected because nobody came out to vote ...
Di Blasio looks bad I agree.

But if we agree he looks bad, then we have to agree guys higher up the food chain don't look good either.
 
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Again, that depends on how seriously you take the numbers. I think what is happening is that the system has simply reached capacity on diagnosing new cases.
How could the social distancing not be working? As opposed to normal everyday NYC? It has to. Logic backs up the #'s.
 
How could the social distancing not be working? As opposed to normal everyday NYC? It has to. Logic backs up the #'s.

That doesn't logically follow. Social distancing means we don't have as many cases as we could have had. It doesn't necessarily follow that social distancing has started to lead to decreased cases as time goes on.. Let's hope that's happening, but we don't know that yet.
 
DiBlasio looks very bad because his encouraging of the chinese celebration looks to be a political reaction to Trump's chinese travel ban.

But despite the travel ban there was very much a down playing of the situation from the federal gov't. I have to believe DiBlasio was not being given information from the fed's that said this is a serious issue. And if they were giving him that information, and he was going to ignore it, the fed's should have stepped in.

I think it is hard to pin the blame on a mayor for not having proper information regarding a pandemic that was at that time, was primarily in China.
The downplaying of the "federal government" was because of the medical experts IN the "federal government"... they were downplaying it.
 
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I referred recovered patients to donate to Columbia, UPenn but it's a problem catching them at the right time and getting follow up testng to prove that they're negative several times before they'll take their plasma. It's an exhausting process.
By the way have you seen the list of companies who have applied to the FDA testing for point of service? It reads like a takeout menu from a Chinese restaurant.

https://www.fda.gov/medical-devices...al-devices/faqs-diagnostic-testing-sars-cov-2
I wonder if it would simply be easier to go right to the antibody test, especially since we know the PCR viral test is not particularly sensitive, meaning people with low, but non-zero viral loads will still be donating, even if they have negative viral tests
There are many challenges for the use of serum transfer. Among them is that detectable neutralizing antibodies to coronaviruses do not last long past resolution of the infection. Neutralizing antibodies (these are antibodies that bind to the virus and either block its entry into cells or cause its destruction) waned as fast as 4 months in people with SARS-CoV-1 infections.

Furthermore, a really nice pre-print study (which has not yet been peer reviewed) from Shanghai, shows that ~30% of recovered people (N=275) did not have detectable levels of neutralizing antibodies. I was very surprised and worried to see these data.

If verified, these results not only impact serum transfer efforts, but also might not be protected from reinfection. But please understand, neutralizing antibody concentrations are only one of several factors that protect people from reinfection, so don't freak out.

If these data are verified, it also might mean that a serological test (which tests for antibodies against the virus to show who has previously been injected) might have a very high error rate. Again, there are caveats to this.

Here's the link for those who like to read primary scientific literature: https://www.medrxiv.org/content/10.1101/2020.03.30.20047365v1

Absolutely, great points. Still much we don't know about antibody levels and neutralizing antibodies (and memory B cells and more), including are our tests discriminatory enough and even if they are, do we know how much of which component is key to immunity and for who long and in which patients, etc., etc.. The Scientific American article provides an easier to read, but still pretty insightful, overview of many of the issues and the 2nd one has a deeper take on the science.

That's why I'm simply so curious to see the results of the trials of the plasma therapy, i.e., can we at least confirm remission of very serious viral infections, as was seen in the two small Chinese studies (with 5 and 10 seriously ill patients, including on ventilators)? If that is confirmed and that's all it does (i.e., even if it doesn't confer long term immunity), even that is huge and scalable for 10,000 seriously ill patients in the US. If it's much more effective early in the infection, then scalability would be more difficult with obviously many more patients.

https://www.scientificamerican.com/article/what-immunity-to-covid-19-really-means/

https://onlinelibrary.wiley.com/doi/epdf/10.1111/vox.12926
 
The downplaying of the "federal government" was because of the medical experts IN the "federal government"... they were downplaying it.

If that is true, then I agree. But would that not let DiBlasio off the hook? To some extent at least?
 



Apple and Google working together to develop a solution to alert you if you come in contact with someone who has tested positive for COVID-19. Will be Bluetooth short range tracking and opt-in only. Expect to hear a lot about this and "Contact Tracing" in the coming months and many debates about the privacy and security concerns that come with it.

Announcement: https://blog.google/inside-google/c...e-partner-covid-19-contact-tracing-technology
Whitepaper: https://blog.google/documents/58/Contact_Tracing_-_Bluetooth_Specification_v1.1_RYGZbKW.pdf
High Level Slides: https://blog.google/documents/57/Overview_of_COVID-19_Contact_Tracing_Using_BLE.pdf

I for one am shocked that they are willing to team up to collect even more data on people. Surely it is wholly out of the goodness of their hearts and I expect a change in their respect terms of use any day to confirm this data will not be sold to third parties or monetized.
 
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How America was hit with COVID-19 from two continents: Majority of cases in US epicenter New York came from Europe - but a DIFFERENT strain spread from China to the West Coast, genome studies reveal


PXTVlzZ.jpg



https://www.dailymail.co.uk/health/...-COVID-19-two-continents-studies-suggest.html
 
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I am interested in this study for fighting CV19:

https://www.biospace.com/article/re...cal-trial-of-apn01-for-treatment-of-covid-19/

APN01 is a recombinant human Angiotensin Converting Enzyme 2 (rhACE2) and was developed by APEIRON biologics for the treatment of acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and pulmonary arterial hypertension (PAH). After licensing from APEIRON in February 2010, GlaxoSmithKline (GSK) conducted several clinical trials from 2014 to 2017 to treat ALI/ARDS and PAH patients, lung injury being the major source of Covid-2019 mortalities, the disease caused by the new corona virus SARS-CoV-2. In 2019, APEIRON obtained the APN01 licenses back from GSK for further clinical development, after a their strategic refocusing of GSK to oncology.

The ACE2 receptor is expressed in human airway epithelia as well as lung parenchyma and was previously identified as the essential gateway used by the first SARS-CoV virus to infect human cells. ACE2 is also the critical receptor for the new virus SARS-CoV-2 to enter human cells. Thus, treatment with recombinant human ACE2 could be used to not only block viremia but also protect lungs and other organs from injury. The drug candidate is administered intravenously as an infusion and has already shown safety and tolerability in 89 patients and volunteers.


Great find. Buy me some of that stock.
That is the key to stop this infection..at the receptor site which will then prevent the cascade which leads to the pneumonia phase of infection and then the phase that looks like high altitude pulmonary edema/pulmonary hypertension because they have different treatments depending on which presentation the patient has at what phase of the illness. Some look like typical pneumonia and just need some oxygen for a while and some look like complicated pneumonia with ARDS and some look like high altitude pulmonary edema where some sort of ultra-inflammatory reaction is set off and the blood vessels are involved and you get a lot of what we call ventilation perfusion mismatch and lung damage from using too high of peep as we try to force high pressurized O2 into inflamed like a vasculitis thickened microcirculationof the alveoli. It's this phase where I think the donor serum could be helpful if pooled from enough donors from the same geographical area. By the way I haven't seen any antibody test that's without its faults and you can have a cross-reactivity with other Corona viruses so you're not going to be able to identify donors with an antibody test at this time.
 
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That doesn't logically follow. Social distancing means we don't have as many cases as we could have had. It doesn't necessarily follow that social distancing has started to lead to decreased cases as time goes on.. Let's hope that's happening, but we don't know that yet.
If you are starting from a point of an infected population that has not practiced social distancing for weeks(if not longer) then it would follow that social distancing would lead to decreased cases over time.
 
If you are starting from a point of an infected population that has not practiced social distancing for weeks(if not longer) then it would follow that social distancing would lead to decreased cases over time.
Both of you have valid points. Cases should be going down because of distancing, and probably are, however, there's no way to tell how widespread infection still is without more testing. Drive thru testing sites are still limited to a few hundred a day, and only for those showing symptoms that are serious enough to concern medical professionals. So that potential number of infections reported in NJ are kind of capped by the number of tests processed per day. My cousin just recovered from the virus after 11 days in the hospital. My uncle tested positive as well, but was at home. My aunt and other cousin showed some symptoms, but were told that they weren't serious enough to test, but should assume they have it. Their numbers do not get included in the daily report of new cases.
 
Great find. Buy me some of that stock.
That is the key to stop this infection..at the receptor site which will then prevent the cascade which leads to the pneumonia phase of infection and then the phase that looks like high altitude pulmonary edema/pulmonary hypertension because they have different treatments depending on which presentation the patient has at what phase of the illness. Some look like typical pneumonia and just need some oxygen for a while and some look like complicated pneumonia with ARDS and some look like high altitude pulmonary edema where some sort of ultra-inflammatory reaction is set off and the blood vessels are involved and you get a lot of what we call ventilation perfusion mismatch and lung damage from using too high of peep as we try to force high pressurized O2 into inflamed like a vasculitis thickened microcirculationof the alveoli. It's this phase where I think the donor serum could be helpful if pooled from enough donors from the same geographical area. By the way I haven't seen any antibody test that's without its faults and you can have a cross-reactivity with other Corona viruses so you're not going to be able to identify donors with an antibody test at this time.
I found that link while trying to search for existing receptor site research. I found some articles that led to that site. It has been a long time since my days on the bench but truth be told I miss it badly. Sure I moved out and up and made plenty of money but the most enjoyment/satisfaction I had in my career was on the bench.
 
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