COVID-19 Pandemic: Transmissions, Deaths, Treatments, Vaccines, Interventions and More...
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i think this is how they are targeting september:
https://www.businessinsider.com/ind...ord-university-vaccine-before-approval-2020-4
Serum hopes to produce 40 million doses by september/october.
he thinks the cost per dose would be around $13.
he is also not looking to patent or make money on it.
hope this works.
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dont have all the details. Just know she was at home, he called 911 when they got there she was already dead. They told him she had to much fluid on her lungs t revive her. he thought he was having an asthma attack
I don’t think you’re in the profession to know this but for others out there who are....would a pulse oximeter have helped to detect this condition earlier and get help sooner before it reached such a stage?
Have seen a couple rheumatoid arthritis drugs on trial, one I think stopped for less severe patients but still ongoing for more severe patients. Now one with a heart burn drug that might be helpful in treating patients. Will probably see a shortage of pepcid now, OTC Zantac been recalled too recently.
https://www.cnbc.com/2020/04/28/hea...elp-treat-coronavirus-hospital-ceo-says-.html
https://www.cnbc.com/2020/04/28/hea...elp-treat-coronavirus-hospital-ceo-says-.html
Interesting paper on the role of Vitamin D in COVID outcomes. It's a retrospective analysis from existing serum data on COVID patients, so it requires a decent sized grain of salt, but it certainly seems like there is the potential for significant benefit from Vitamin D supplementation in patients - enough potential for a clinical trial at least, especially given how available/cheap Vitamin D is. More sunshine and milk?
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3571484
The second paper is more of an epidemiological study looking at countries/locations with high and low vitamin D levels and correlating them to COVID outcomes. Another large grain of salt required, but the theory is at least intriguing.
https://www.researchsquare.com/article/rs-21211/v1
The third link is to a study being planned on this in SC.
https://abcnews4.com/news/coronavir...nnection-to-covid-19-prevention-and-treatment
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3571484
The second paper is more of an epidemiological study looking at countries/locations with high and low vitamin D levels and correlating them to COVID outcomes. Another large grain of salt required, but the theory is at least intriguing.
https://www.researchsquare.com/article/rs-21211/v1
The third link is to a study being planned on this in SC.
https://abcnews4.com/news/coronavir...nnection-to-covid-19-prevention-and-treatment
There's a reason they occasionally have to replace workers.
Dude, we had Captain America leading the charge, so it was pretty easy at that point to predict when the war would end!
It just seems like they're taking a look at almost anything be it malaria drugs, BCG, RA drugs, acid reflux drugs, vitamin D....etc..and see what sticks and even if it looks like it might stick I'd still wonder because it's all so new.
Desperate times. I completely understood the original excitement and need for HQC testing, but hated the hype and the result that probably way too much medical focus was placed on it, to the exclusion of testing a number of other drugs. Why not try some of these things when not much seems to be working...
Just to be complete, there are thought to be 7 coronaviruses that infect humans (229E, HKU1, NL63, MERS, SARS-CoV and now SARS-CoV-2). 4 of these are endemic - in other words they are spread throughout the population and are present all the time - they cause ~30% of "colds". A couple of them have been in humans for at least 1000 years.
The recent ones can cause severe illness and death. The experts (like Stanley Perlman, UPenn) suggest that coronaviruses "self-attenuate" - they change themselves such that they are less damaging to the host. The goal of a virus is to make more virus - not to kill people.
So the question is whether or not the next coronavirus that can infect humans will cause a cold, cause a high % of death (like MERS) or cause another pandemic.
I just hope they don't screw up the testing the way they have with HCQ testing. To date there is no available clinical data on early treatment of Covid19 with HCQ. In fact our government has recommended to treat only in hospital setting and that is typically 7 days or more after onset. How about actually doing a study on patients at onset...are we really this freaking dumb?
Anything being tested for potential inhibition of viral replication should be given at onset of symptoms to have the best chance of success. Taking any potential anti-viral and waiting until the patient is overrun a week or more after onset makes little sense. It is like putting on a seatbelt after the accident. That is how dumb we are approaching this virus. Think about that???
Obviously, drugs such as IL-6 inhibitor would make more sense at the CRS/CS stage.
Here are some simple examples using ZOVIRAX:
Treatment of Herpes Zoster
800 mg of oral ZOVIRAX®, every 4 hours, 5 times daily for 7 to 10 days. Treatment should be initiated within 72 hours of the onset of lesions. In clinical trials, the greatest benefit occurred when treatment was begun within 48 hours of the onset of lesions.
Treatment of Chickenpox
20 mg/kg (not to exceed 800 mg) orally, 4 times daily for 5 days. Therapy should be initiated within 24 hours of the appearance of rash.
Anything being tested for potential inhibition of viral replication should be given at onset of symptoms to have the best chance of success. Taking any potential anti-viral and waiting until the patient is overrun a week or more after onset makes little sense. It is like putting on a seatbelt after the accident. That is how dumb we are approaching this virus. Think about that???
Obviously, drugs such as IL-6 inhibitor would make more sense at the CRS/CS stage.
Here are some simple examples using ZOVIRAX:
Treatment of Herpes Zoster
800 mg of oral ZOVIRAX®, every 4 hours, 5 times daily for 7 to 10 days. Treatment should be initiated within 72 hours of the onset of lesions. In clinical trials, the greatest benefit occurred when treatment was begun within 48 hours of the onset of lesions.
Treatment of Chickenpox
20 mg/kg (not to exceed 800 mg) orally, 4 times daily for 5 days. Therapy should be initiated within 24 hours of the appearance of rash.
Watch what happens as we collectively start to move outside more and more and get real exposure to Vitamin D and some fresh air.
Will do us all some good. All.
That's funny. I was taking generic famotidine recently for heartburn, but haven't needed it lately.
New Jersey just reported 402 deaths today. That's the biggest one-day jump. Not all of these deaths happened yesterday. This shows that the daily figures on weekends are apt to be way low, and so we shouldn't put too much weight on the weekend numbers. Clearly it's a bad sign that NJ is reporting so many deaths this far in, even on a Tuesday. Note some good news: the number of hospitalizations is down, although not as much as it should be. https://www.nj.com/coronavirus/2020...wsletter - Coronavirus#cmpid=nsltr_strybutton
Yep, my good friend from India who knows a lot more than I do about all this just emailed me about this. There's still the problem that the Serum Institute is only looking at 5-10MM doses/month through the end of this year, which is a drop in the bucket for the world or even India (or the US). Scaling vaccine manufacturing is not easy at all and the US better be getting on top of this if we don't want to be frozen out of vaccine supplies when they come on line. It could easily take a year to make enough doses for the entire country, even if a vaccine is approved in the fall - one would imagine vaccines would be reserved for health care workers, public facing essential jobs and the elderly and those with major underlying conditions, at first.
https://www.livemint.com/news/india...ccine-that-is-under-trial-11587889621799.html
No issues with it at all, scattershot and hopefully something hits the target. Unfortunate side effect is people going out and stockpiling things that aren't even proven yet.
Talked to many along the waterfront in Woodbridge watching the flyover... most respecting distances... wearing masks except one younger fireman / EMT who also was smoking ... he did not put a mask on after his puffing was done... probably mid to late 40’s... he was in dress uniform and going to Woodbridge‘s main First Aid Station off routes 1&9 for a helicopter flyover... I think the best part was when he asked if I thought he was too close ...Really? You are smoking and within about 6 feet of many over 65 year olds...When I told him my age I thought he would choke... this is just too sad... as an add on ... went through NJ.com obits about 200 people... found several parents of those I graduated from HS back in ‘68 had passed during this crisis... 90 percent were over 80... many in assisted living facilities ...very few under 60... some also had severe illness prior
Because of weekend (especially Sunday) reporting anomalies I would just look at 508 deaths over the last two days instead. 265 of those deaths were in LTCs.
The pattern for at least the past 4 weeks in NJ is that we see a sharp drop in deaths on reported on Sun & Mon (deaths occurring on Sat & Sun), followed by a huge spike on Tuesday.
Part of this is because reporting is down from local sites over the weekend. So a good portion of the deaths that occur on Sat & Sun don't get reported to the State until Monday, and reported in the daily totals released on Tuesday.
Part of the reason is also that test results are delayed, and often not reported over the weekend. So if someone dies on Thursday without a positive Covid test result, and the test result isn't reported to the hospital until Monday, then the Thursday death is included in the Monday reporting result.
If you look at a rolling average of reported deaths (which helps eliminate some of the daily spikiness), the overall trend is down.
https://agilum.com/agilum-releases-nationwide-covid-19-real-world-data-rwd-survival-rate-analytics/
Just a note, last data I saw for percentage of hospitalized patients who died was 22.4% 4/12/20).
In the link above, here is data: (Note 12% of people on HCQ died versus 22.4% of all NYC Hospital patients which includes those mentioned below who might have been treated in NYC. What does that mean? The death % outside of the treatments below is more than likely > 22.4% since the combo of all patients gives you 22.4%. I would love to see the death % of all patients without the treatments to compare to below with treatments. I include the NYC hospital data as the second table but remember they are two separate views. One is treatment results reported nationally (4/28) and the second is NYC data on 4/12.
Just a note, last data I saw for percentage of hospitalized patients who died was 22.4% 4/12/20).
In the link above, here is data: (Note 12% of people on HCQ died versus 22.4% of all NYC Hospital patients which includes those mentioned below who might have been treated in NYC. What does that mean? The death % outside of the treatments below is more than likely > 22.4% since the combo of all patients gives you 22.4%. I would love to see the death % of all patients without the treatments to compare to below with treatments. I include the NYC hospital data as the second table but remember they are two separate views. One is treatment results reported nationally (4/28) and the second is NYC data on 4/12.
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Perfect weather for golf!! But our governor won’t open the courses while they are open almost every where else!!
Very interesting article on a group of top scientists and billionaires working together on a kind of "Manhattan Project" blueprint to combat COVID-19. They've gotten their 17-page report into the hands of VP Pence and others in the White House. Thought the comments on HCQ (barely mentioned), antibody "immunity cards" (dismissed as dumb), and FDA red tape (want 1 week to approve new drugs) were fascinating.
Team includes Ed Scolnick, the brilliant and difficult former head of R&D at Merck, who I met several times over the years and even gave a presentation to once (scariest day of my professional life, lol - was happy I didn't get yelled at). I'm sure there's more to come...
https://www.straitstimes.com/world/...-manhattan-project-seeking-to-combat-covid-19
Calling themselves Scientists to Stop Covid-19, the group of a dozen scientists - including chemical biologists, an immunobiologist, a neurobiologist, a chronobiologist, an oncologist, a gastroenterologist, an epidemiologist and a nuclear scientist - are marshalling brains and money to distil unorthodox ideas from around the globe.
They have described their work as a lockdown-era Manhattan Project - a reference to the World War II scientists who helped develop the atomic bomb - and are led by a 33-year-old physician-turned-venture capitalist, Dr Tom Cahill...
...The team also pledged to avoid politics in an election year. Hydroxychloroquine, a malaria drug promoted by the President, received only a passing mention in the final report.
The group also disparaged the idea of antibody testing to allow people back to work. Dr Cravatt, a chemial biologist, called it the "worst idea I've ever heard", pointing out that prior exposure may not prevent people from giving the virus to others. There were also concerns that people might intentionally infect themselves to obtain a clean bill of health later.
The groups initial recommendations in the report centre on the government's response. One suggestion was to buy medicines not yet proven effective as a way to encourage manufacturers to ramp up production . Another was to slash the time required for a clinical review of new drugs to a week from up to a year at present.
Team includes Ed Scolnick, the brilliant and difficult former head of R&D at Merck, who I met several times over the years and even gave a presentation to once (scariest day of my professional life, lol - was happy I didn't get yelled at). I'm sure there's more to come...
https://www.straitstimes.com/world/...-manhattan-project-seeking-to-combat-covid-19
Calling themselves Scientists to Stop Covid-19, the group of a dozen scientists - including chemical biologists, an immunobiologist, a neurobiologist, a chronobiologist, an oncologist, a gastroenterologist, an epidemiologist and a nuclear scientist - are marshalling brains and money to distil unorthodox ideas from around the globe.
They have described their work as a lockdown-era Manhattan Project - a reference to the World War II scientists who helped develop the atomic bomb - and are led by a 33-year-old physician-turned-venture capitalist, Dr Tom Cahill...
...The team also pledged to avoid politics in an election year. Hydroxychloroquine, a malaria drug promoted by the President, received only a passing mention in the final report.
The group also disparaged the idea of antibody testing to allow people back to work. Dr Cravatt, a chemial biologist, called it the "worst idea I've ever heard", pointing out that prior exposure may not prevent people from giving the virus to others. There were also concerns that people might intentionally infect themselves to obtain a clean bill of health later.
The groups initial recommendations in the report centre on the government's response. One suggestion was to buy medicines not yet proven effective as a way to encourage manufacturers to ramp up production . Another was to slash the time required for a clinical review of new drugs to a week from up to a year at present.
One of the most fascinating things I have ever heard about. What an incredible collection of influence and talent
This is a letter published to the Arizona Gov by the Associations of American Physicians and Surgeons.
It's a conservative group of doctors with about 5000 members.
Well gee that goes against what talking head journalists who act like medical doctors told us
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