I'd be surprised if there still isn't a vaccine year from nowI think it would until a vaccine, at least within the next few years
I don't see it burning out like SARS
I'd be surprised if there still isn't a vaccine year from nowI think it would until a vaccine, at least within the next few years
I don't see it burning out like SARS
Of course it will. That's why we'll need very high testing capacity as well as the ability to contact trace/isolate people who get sick and those they expose. The current measures aren't extreme enough to completely eliminate the virus, it will be a long battle.
Long post on whether we might actually have tens of millions infected already...
A perspective I haven't seen before is in the link below. Not sure I buy it, but the authors claim that we had 10 million cases (~3+% of the population) of symptomatic SARS-CoV-2 as of the week of 3/15, from looking back at CDC influenza tracking data on "Non-Influenza Influenza Like Illnesses," as there was a surge of such reports at that time - and they estimate the symptomatic case detection rate of the coronavirus as being only between 1/100 and 1/1000. I don't claim to understand all of their paper, as it's very math heavy and I wasn't about to try to check their calculations/models. Just thought it was interesting...
https://github.com/jsilve24/ili_surge/blob/master/Silverman_and_Washburne.pdf
If true, this would actually be fantastic, as it would mean we might have 5-10% (or more) of the population right now walking around with antibodies and likely immune, which would allow them to not worry about the virus and would mean any second wave would be deprived of a large number of targets. As per the post above, this is why doing antibody testing of a random, representative population is so important, so we can know what percentage of the general population is actually infected and likely immune (the Diamond Princess did show 19% of passengers with CV2, about half of which were asymptomatic). Or at least test every passenger from the DP for antibodies to get a good first guess of the total actual infection rate in the overall population.
This would also mean that the actual IFR (infection fatality rate) is way lower than the CFR (case fatality rate). In the US, for example, the CFR is 2.7% (8454 deaths per 311,600 positive cases), while if we had, say, 33MM infections by now (10% of the population), the IFR would only be 0.02%.
However, to make a meaningful comparison to something like the flu, we'd need the symptomatic illness fatality ratio, which is what the CDC tracks, which is roughly 35,000 deaths per year out of 35,000,000 symptomatic illnesses, which is where the 0.1% "fatality rate" we often see comes from. The CDC doesn't actually track and test all of these illnesses, obviously - they use models, which typically extrapolate from hospitalization rates.
https://www.cdc.gov/flu/about/burden/index.html
Getting back to COVID-19, we know the number of people with actual symptoms is far, far less than 33MM and a decent guess of how many have symptoms is probably the number of tests we've run, so far, since most areas are only testing symptomatic people (1.65MM tested so far). So 8454 deaths/1.65MM symptomatic cases (0.5% of the US population) would be 0.5%, which is about 5X the death rate for the flu. Most projections right now are guesstimating 70-200K deaths (mine has been ~85K) from the coronavirus, assuming fairly aggressive social distancing is maintained and 5X the flu death rate would be 175K deaths, which is in that range, so it's possible this theory isn't crazy.
On the flip side, the reason i'm skeptical is that, so far, the Telluride antibody test program, where they're testing the entire 8000 person county for free, is only showing 1% of the population with antibodies after testing 1000 people, although another 2% had indeterminate results and could be positive. Even at 1%, though, that's still a lot more than the positive case percentage in the US of 0.5% (and Colorado's 0.1% positive cases per capita), but 1% is also a far cry from 10% of the US infected.
https://www.cpr.org/2020/04/02/tell...e-positive-results-but-also-more-uncertainty/
Another issue I have with having so many infections in March, is why didn't we see a lot more infections and deaths in Feb or even Jan, since they can't all come at once in March into April? And then I thought maybe it's possible that we had 5K infected by the end of January and 50K infected by the end of February (with maybe a few hundred deaths in Jan/Feb being erroneously ascribed to flu, as we know we had COVID cases back then, looking back at samples and people with symptoms that weren't recognized as COVID) and we now have millions infected today, actually, (not the 311K positive cases). Maybe this is all crazy, I don't know. Having a hard time reconciling so much conflicting data, probably because we're simply missing so much data, which is not unusual in the first few months of a pandemic.
What do we think happens once we stop social distancing? Is there any reason to think it will not just start to spread again once we start interacting with each other?
Crazy to see we're still running short on test kits/PPE and that there is such a reporting lag. By the time some of these folks are notified, they could already be in the ICU or dead, let alone infecting others.
More people will die from substance abuse and suicide than this virus as a result of the government actions to protect the people.
I'd be surprised if there still isn't a vaccine year from now
I don’t think depression and similar problems are a choice weirdo.That's their choice.
It's not a choice to catch a deadly virus just by shaking someone's hand or picking up dinner at the store.
They are treating the wrong disease condition. Patients are not being "tired out" and need of ventilators. They are being starved of O2 because their hemoglobin has been stripped of Iron.Some doctors moving away from ventilators for virus patients
https://apnews.com/8ccd325c2be9bf454c2128dcb7bd616d
That's their choice.
It's not a choice to catch a deadly virus just by shaking someone's hand or picking up dinner at the store.
Seems that person made a choice to shake someone's hand or pick up dinner at the store.
September is definitely a reach. I know nothing about this stuff but from doctors that I've listened to it sounds like it will take about a year... Maybe being pushed up a bit due to the magnitude this emergency.Pray for one by September
That would be fantastic, because that would mean the fatality rate would be minuscule at the current levels.If, for argument's sake, 30% of the population has already been infected and is now immune, that's great and horrible at the same time.
Actually, the article doesn't include any results. Just says it's being used on 20 seriously ill patients. A bit frustrating actually - dying to see the actual results.SIAP -- news account of success with plasma antibody treatment.
https://www.yahoo.com/news/plasma-treatment-being-tested-york-213100838.html
They are treating the wrong disease condition. Patients are not being "tired out" and need of ventilators. They are being starved of O2 because their hemoglobin has been stripped of Iron.
Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.
When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.
Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:
1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.
2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.
— — — — — — — — — — — — -
Once your body is now running out of control, with all your oxygen trucks running around without any freight, and tons of this toxic form of iron floating around in your bloodstream, other defenses kick in. While your lungs are busy with all this oxidative stress they can’t handle, and your organs are being starved of o2 without their constant stream of deliveries from red blood cell’s hemoglobin, and your liver is attempting to do its best to remove the iron and store it in its ‘iron vault’. Only its getting overwhelmed too. It’s starved for oxygen and fighting a losing battle from all your hemoglobin letting its iron free, and starts crying out “help, I’m taking damage!” by releasing an enzyme called alanine aminotransferase (ALT). BOOM, there is your second of 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.
Eventually, if the patient’s immune system doesn’t fight off the virus in time before their blood oxygen saturation drops too low, ventilator or no ventilator, organs start shutting down. No fuel, no work. The only way to even try to keep them going is max oxygen, even a hyperbaric chamber if one is available on 100% oxygen at multiple atmospheres of pressure, just to give what’s left of their functioning hemoglobin a chance to carry enough o2 to the organs and keep them alive. Yeah we don’t have nearly enough of those chambers, so some fresh red blood cells with normal hemoglobin in the form of a transfusion will have to do.
The core point being, treating patients with the iron ions stripped from their hemoglobin (rendering it abnormally nonfunctional) with ventilator intubation is futile, unless you’re just hoping the patient’s immune system will work its magic in time. The root of the illness needs to be addressed.
Best case scenario? Treatment regimen early, before symptoms progress too far.
How? He's the most reasonable person from Fox news. All he was doing in the video in giving out statistics. some people don't like that because they're offended by people that aren't running around panicking.This guy is an absolute moron.
I'm hoping you were simply hoodwinked by the fancy language in the first part of the Medium blog (first link and Medium doesn't verify anything in their posts) by libertymavenstock and didn't actually cut/paste part of this from the apparent actual author and all around nutjob jarasan's blog (2nd link).
This guy is so far out in right field that nobody should be taking him seriously - just look at the rest of his blog after the hemoglobin stuff, below or any of his other entries. His HCQ part 2 of his blog is also completely off the rails, featuring this gem: "All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as the biggest Fake News blunder to rule them all. The media actively engaged their activism to fight ‘bad orange man’ at the cost of thousands of lives. Shame on them."
He's also not a doctor, which he admits, and scientifically, here's the reaction from a well respected MD in NYC from another board, who is currently treating COVID-19 patients, after being asked about the Medium version of the blog: "Complete BS. I don’t even know where to start."
https://blogs.lotterypost.com/jarasan
Sunday, April 5, 2020
FIFU. Quomo is not POTUS!
Fox is Fuquing Up continuously, they have Quomo on there again. Put him on NY public TV, this frinking mumbling goombah is not GEOTUS! WTF! Losing viewers bigly!
posted by jarasan # 11:19 AM 0 comments
Friday, April 3, 2020
Karma is a sinking ship.[/paste:font]
Venezuela has got the corona blues, what a beautiful example of karma!!!!!
These f'ing drug dealers with a navy deserve no less, Maduro will be gone before 2021.
posted by jarasan # 12:09 AM 4 comments
So here’s what we need to do to bring this thing to an end so that America can begin the larger recovery: Refuse to fear. The media, the swamp, and politically motivated Never Trumpers, Democrats, and the left are all trying to get you to lose your mind. Don’t let them. Clean and reload all the firearms in your home. Participate with your friends through their social media push-up challenges. Take an Instagram yoga time out. Enjoy the free American Ballet Theater virtual ballet classes with your baby girl. Or send your boys to their virtual Taekwondo class on YouTube. Live, and never let anyone stop you.
so what is your issue here, tell me that giving this drug to hundreds of people didnt matter including some who woke up the next morning feeling 1000% better.
Looks like most of the coronavirus infections in the NYC area came from people who traveled to NYC from Europe, based on two parallel viral genome studies. This is why travel bans probably only really work in our modern world when the entire world is locked down. Also, given how transmissible the virus now appears to be, there probably is no way it ever could have been stopped, since by the time an outbreak is noticed, asymptomatic people would have always traveled out of the source region. All an earlier lockdown/travel ban would likely have done is delayed the pandemic, not denied it.
The other tidbit from the article is that genome analyses have confirmed that the virus came from bats, not a lab in Wuhan. "Maciej Boni of Penn State University and his colleagues recently used this method to see where the coronavirus, designated SARS-CoV-2, came from in the first place. While conspiracy theories might falsely claim the virus was concocted in a lab, the virus’s genome makes clear that it arose in bats."
https://www.nytimes.com/2020/04/08/...ope-genomes.html?referringSource=articleShare
But doesn't this prove the travel ban actually worked? That is, it seems to have prevented the virus from coming from China. The problem seems to be that the ban wasn't broader earlier.
I did not get it from there. In fact I had not seen that until you linked him. That guy is a whacko. I got it on a critical care site discussing these articles:I'm hoping you were simply hoodwinked by the fancy language in the first part of the Medium blog (first link and Medium doesn't verify anything in their posts) by libertymavenstock and didn't actually cut/paste part of this from the apparent actual author and all around nutjob jarasan's blog (2nd link). Or maybe this guy jarasan (and you) got it from somewhere slightly more legit (I hope).
This guy is so far out in right field that nobody should be taking him seriously - just look at the rest of his blog after the hemoglobin stuff, below or any of his other entries. His HCQ part 2 of his blog is also completely off the rails, featuring this gem: "All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as the biggest Fake News blunder to rule them all. The media actively engaged their activism to fight ‘bad orange man’ at the cost of thousands of lives. Shame on them."
He's also not a doctor, which he admits, and scientifically, here's the reaction to the hemoglobin first part from a well respected MD in NYC from another board, who is currently treating COVID-19 patients, after being asked about the Medium version of the blog: "Complete BS. I don’t even know where to start."
https://blogs.lotterypost.com/jarasan
Sunday, April 5, 2020
FIFU. Quomo is not POTUS!
Fox is Fuquing Up continuously, they have Quomo on there again. Put him on NY public TV, this frinking mumbling goombah is not GEOTUS! WTF! Losing viewers bigly!
posted by jarasan # 11:19 AM 0 comments
Friday, April 3, 2020
Karma is a sinking ship.[/paste:font]
Venezuela has got the corona blues, what a beautiful example of karma!!!!!
These f'ing drug dealers with a navy deserve no less, Maduro will be gone before 2021.
posted by jarasan # 12:09 AM 4 comments
I saw an interesting theory that the reason children aren't getting this virus is because they produce much higher amounts of melatonin than do the aged.
How? He's the most reasonable person from Fox news. All he was doing in the video in giving out statistics. some people don't like that because they're offended by people that aren't running around panicking.