Same here, very tired of your schtick. I have 95% of medical science on my side and you have the discredited Didier Raoult, Elon Musk and Dr. Trump on your side. HCQ is simply not effective and is actually dangerous for hospitalized COVID patients. You simply can't see the forest for the trees and keep looking for minor differences that don't really mean anything when all you have to look at is that the HCQ and comparators were matched pretty damn closely and the mortality rate was significantly greater for the HCQ patients. For a huge sample size of 15K/80K.
Don't you think that if HCQ had any efficacy at all there would have at least been some signal in a huge dataset like that? And maybe the ICU stays were longer and ventilation needs were greater for the HCQ patients because HCQ was actually worse for patients than the control - hence the eventual greater mortality rate as an outcome.
And yes, I misspoke on moderate - should have simply said less severe vs. more severe, as they did exclude the most severe patients (intubated) at start of HCQ treatment from the HCQ data, but you're correct that it's generally at least severe to be admitted to the hospital. By the way about 20% of COVID cases end up in the hospital, not 3%. And I didn't even bring Lowe's blog up today, although since you asked, he savaged HCQ in it today and rightly so.
https://blogs.sciencemag.org/pipeline/archives/2020/05/22/hydroxychloroquine-enough-already
From Lowe's Blog: But I’m going to leave it at this. There was no evidence whatsoever of any benefit with any of these treatment regimes. There was significant evidence of harm. Here’s how it works: when something is real, you continue to see a real signal as you collect more and better data. When something is not real, it disappears. Tell me again why anyone should be advocating such treatments. But your reasons had better stand up to 14,888 patients versus 81,144 comparators. Make it good.
At this point, there's probably not much more productive from continuing this conversation. Let's see what happens with the prophylactic and mild symptom studies, although I'm surprised you're simply going to buy the reports from India on this without a scientific paper/description behind it. The only published data I've seen so far on prevention of getting COVID has been from lupus patients on HCQ, who are significantly more likely to get COVID than RA patients. Granted they're not "typical" patients, but that's certainly not a good sign for prevention.