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COVID-19 Pandemic: Transmissions, Deaths, Treatments, Vaccines, Interventions and More...

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Missed a big detail last night in the Pfizer/BioNTech announcement. They're actually going forward into Phase II/III trials with the BNT162b2 mRNA vaccine candidate, not the BNT162b1 mRNA vaccine candidate, which had been the focus of all the press and papers to date. The differences are in what parts of the SARS-CoV-2 spike protein and other proteins are encoded into the chimp adenovirus vector. Derek Lowe explains it nicely in today's In the Pipeline, below. Sorry for missing that last night. I don't think it really makes a huge difference, since both, supposedly had similar responses in humans, with the b1 version having a slightly better T-cell response and lower levels of side effects. Hopefully, they've made the right choice.

https://blogs.sciencemag.org/pipeli.../pfizer-and-biontech-pick-a-vaccine-candidate

It comes down to the antigen(s) being coded for. The b1 candidate, the one we’ve been hearing about, codes for the coronavirus Spike protein’s receptor-binding domain (RBD), and this was constructed as a trimer, three RBDs attached to a “foldon” protein core. Meanwhile, the b2 candidate codes for what they say is an “optimized full-length Spike” protein instead, not just the receptor-binding domain. Pfizer’s press release says that both the b1 and b2 candidates “induced favorable viral antigen specific CD4+ and CD8+T cell responses, high levels of neutralizing antibody in various animal species, and beneficial protective effects in a primate SARS-CoV-2 challenge model“. But they made the choice for the b2 variety partly because it seemed to be better tolerated on injection, and also because it led to a wider variety of T-cell responses. These include both CD4+ and CD8+ T-cells, and these were raised not only to recognize the RBD region, but also other regions of the Spike protein that weren’t contained at all in the b1 candidate. And they’re quite right – that could well be beneficial, and the better tolerability is a bonus. The release says that the neutralizing antibody response was similar between the two candidates.

I saw that too. I thought they were going ahead with both, but apparently read that wrong. Thanks for explaining.
 
So, lots of information coming out today about Stella Immanuel. Personally I prefer to get my information from doctors that don't think cysts and some other medical issues that women have come from having sex with a demon in a dream. Or that God/Jesus is going to destroy Facebook's severs.

I posted her Twitter thread last night - she's not all there and only folks in the HCQ Army think she's credible (or that the Zelenko paper is credible).
 
Sorry, but that is Blather

No, it's not. Every randomized, controlled HCQ trial (RCT) whether in severe, moderate or mildly ill patients and as a prophylactic pre/post exposure, has shown no benefit, as have most observational studies (but not all, which is not a surprise, since observational studies suffer from very large variability, due to lack of control). The issue isn't that studies shouldn't have been done, it's that the controlled studies should have been done first and right away, but were not, and we ended up giving tens of thousands (maybe even hundreds of thousands) of patients a completely unproven drug with clearly more side effects than standard treatments. All of those people could, instead, have been enrolled in trials for other potentially lifesaving drugs.

Azithromycin and zinc have been in some but not all of those and we haven't had any RCTs done with the HCQ/Az/Zn combo, so the jury is still out on that - plus, as I posted yesterday, Zelenko's "study" will never be published by anyone as it's laughably bad, with no data, whatsoever, supplied for his purported "control" population. It's unlikely the combo will be any better, but we won't know for sure without an RCT on it, and we better not start giving another unproven treatment to mass numbers of patients. And while I'm not a fan of censorship, Twitter, FB and YouTube have deleted the video.

https://ktla.com/news/nationworld/f...o-of-doctors-making-false-coronavirus-claims/
 
Yep, more proof that we simply have a lot of young people who just don't care about possibly infecting their friends, family, coworkers, etc. My son and his girlfriend who are in their early 20s (and living with us and are quite careful) just shake their heads at this kind of behavior. Even though we likely have 10-20% who have been infected in NJ (with the higher numbers near NYC and the lower numbers in the suburbs/rural areas), as some small antibody studies have been done, there's still a long way to go to reach 55-80% infected, assuming that's where this will ultimately go (still some questions on that due to cross-reactivity). Would be far better if we could keep cases down where they've been for a few more months until we have much better treatments and maybe even a vaccine by the end of the year.


maybe the virus is going to virus, no matter what we do, Knightfans gloomy post would make you think we have to get to zero cases. There are spikes all around the world.....and this is happening in countries who have taken great precaution. Guess what, its not going away, people are either going to have to shelter in place for 2 years or try and live their life. Its your choice

and I think the 700 person party held by Newark residents in Jackson can put to rest the notion of ITS THE RED STATES FAULT THAT ALL THIS IS HAPPENING..ITS THEIR GOVERNORS..WAAAAH.

No..its the virus and its going to do what it wants.
 
Two years? Why? there are currently over 2000 clinical trials ongoing of both treatments and vaccines. We've seen improvements in treatment protocols in the past 4-5 months and those improvements should continue. It's looking more likely that we will have a viable vaccine maybe as early as October/November approval for emergency use with roll out to the general public after that. Yes, life sucks right now but if people would adhere to safety guidelines for another 5-6 months we will hopefully get to a place where life is near normal. The country has faced crises like this before (Great Depression, WW2) and we did a better job of pulling together.
 
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maybe the virus is going to virus, no matter what we do, Knightfans gloomy post would make you think we have to get to zero cases. There are spikes all around the world.....and this is happening in countries who have taken great precaution. Guess what, its not going away, people are either going to have to shelter in place for 2 years or try and live their life. Its your choice

and I think the 700 person party held by Newark residents in Jackson can put to rest the notion of ITS THE RED STATES FAULT THAT ALL THIS IS HAPPENING..ITS THEIR GOVERNORS..WAAAAH.

No..its the virus and its going to do what it wants.

It is the virus, but it's going to do what we let it do. The choice is ours, collectively. Many countries have controlled it to very low levels; many have not and we've done worse than most. The spikes in other countries with low cases have been largely contained, but require vigilance to do so. And the other part isn't worth arguing with you over, since you only see things in black and white and shout about them to boot.

Also, if you've been paying attention, many experts believe we'll have a near cure soon, with engineered antibodies, which we'll know about by September, and vaccines by the end of the year, so hopefully, we're only talking 3-6 months before things are much better on a treatment/prevention front. No guarantees on that, since this is a novel virus, but I have pretty high confidence in this, as do many others in the field.
 
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No, it doesn't. A take is an opinion, a statement.
Instead of lamely defecting, answer the question:

"so for everyone who is upset over no one wearing masks and the spike hikes in other states, does this take by you apply to them as well?"

There is a lot of people in here watching other states, but yet you only called out one person. And if I may add a second question, why?
 
So, lots of information coming out today about Stella Immanuel. Personally I prefer to get my information from doctors that don't think cysts and some other medical issues that women have come from having sex with a demon in a dream. Or that God/Jesus is going to destroy Facebook's servers.

Ouch!

love it...you with no medical degree basically repeating msnbc talking points on every subject for the past 4 years dismissing what real medical doctors who have treated covid patients have to say

YUUUUUGGGE Ouch!

Another "so much more knowledgeable than you" doctor down the drain.

Wouldn't it be easier just to wait a day before posting whatever latest doctor opinion supports your narrative? By then, every last trace of said opinion will be scrubbed clean from the Internet for being fake news and you can save the time and embarrassment involved in posting.
 
Instead of lamely defecting, answer the question:

"so for everyone who is upset over no one wearing masks and the spike hikes in other states, does this take by you apply to them as well?"

There is a lot of people in here watching other states, but yet you only called out one person. And if I may add a second question, why?

It's not a deflection. It's what I wrote and you continue misinterpreting.
 
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I found out something last week, to be able to access my company's site, I must have a fever of 100.4 or lower.

Growing up 100 was the benchmark to staying home from school, I haven't had a fever in ages so I forget what 100 feels like (or I've hit it and didn't just realize it), I'm just surprised its set at 100.4.
 
https://rutgers.forums.rivals.com/t...entions-and-more.191275/page-214#post-4620406

Important news should be available this week on the now completed randomized, controlled clinical trial (RCT, the gold standard of clinical science) with Roche's tocilizumab, an IL-6 inhibitor aimed at addressing the overreactive inflammatory response often called the cytokine storm, which is responsible for many COVID deaths, especially in the elderly, whose immune systems often don't work as well as those of younger people. Crossing fingers, as this could be a major step forward if it confirms the very promising mortality reduction results seen in earlier, small-scale observational studies (generally RCTs are required for "proof" of efficacy). More in the link below and some history in the post linked above.

https://www.dailymail.co.uk/health/...-treatment-halt-immune-storm-coronavirus.html
 
https://rutgers.forums.rivals.com/t...entions-and-more.191275/page-214#post-4620406

Important news should be available this week on the now completed randomized, controlled clinical trial (RCT, the gold standard of clinical science) with Roche's tocilizumab, an IL-6 inhibitor aimed at addressing the overreactive inflammatory response often called the cytokine storm, which is responsible for many COVID deaths, especially in the elderly, whose immune systems often don't work as well as those of younger people. Crossing fingers, as this could be a major step forward if it confirms the very promising mortality reduction results seen in earlier, small-scale observational studies (generally RCTs are required for "proof" of efficacy). More in the link below and some history in the post linked above.

https://www.dailymail.co.uk/health/...-treatment-halt-immune-storm-coronavirus.html

Just wait for HCQ guy to come in and tell you how control randomized trials don't matter cause some doctor in Norway said HCQ works in his paper that hasn't been peer reviewed and you have no clue. After all he is a doctor and you (and I) are not.

Thoroughly enjoying how the narrative has now shifted to we are vastly over counting bodies. Good stuff.
 
Positive tests have been up the last several days. However upon inspection, so have tests administered. In fact, our seven day moving average of tests administered is higher than it's been since June 8th. This truth is reflected in the spot positivity rate which hasn't moved above 1 and 2 percent in almost two months.
 
Two years? Why? there are currently over 2000 clinical trials ongoing of both treatments and vaccines. We've seen improvements in treatment protocols in the past 4-5 months and those improvements should continue. It's looking more likely that we will have a viable vaccine maybe as early as October/November approval for emergency use with roll out to the general public after that. Yes, life sucks right now but if people would adhere to safety guidelines for another 5-6 months we will hopefully get to a place where life is near normal. The country has faced crises like this before (Great Depression, WW2) and we did a better job of pulling together.
Because it realistically could take 2 years and maybe more...
 
Last night I posted about lingering heart symptoms in a Red Sox pitcher; seems like this may be a common complication:
https://www.google.com/amp/s/mobile.reuters.com/article/amp/idUSKCN24S2FC
https://www.google.com/amp/s/mobile.reuters.com/article/amp/idUSKCN24S2FC

“More than three-quarters of recently recovered COVID-19 patients had heart muscle problems show up during magnetic resonance imaging (MRI) tests, German doctors reported on Monday in JAMA Cardiology. In some patients, the heart may be "in serious trouble as a part of COVID-19 disease," Dr. Valentina Puntmann of University Hospital Frankfurt told Reuters.”

Was just about to post this and had a nagging thought that someone might've already posted it and found this. Certainly a scary study with 78 out of 100 recovered COVID patients having abnormal heart MRIs. Below is a link to the journal article.

https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916

Results Of the 100 included patients, 53 (53%) were male, and the median (interquartile range [IQR]) age was 49 (45-53) years. The median (IQR) time interval between COVID-19 diagnosis and CMR (cardiovascular MRI) was 71 (64-92) days. Of the 100 patients recently recovered from COVID-19, 67 (67%) recovered at home, while 33 (33%) required hospitalization. At the time of CMR, high-sensitivity troponin T (hsTnT) was detectable (3 pg/mL or greater) in 71 patients recently recovered from COVID-19 (71%) and significantly elevated (13.9 pg/mL or greater) in 5 patients (5%). Compared with healthy controls and risk factor–matched controls, patients recently recovered from COVID-19 had lower left ventricular ejection fraction, higher left ventricle volumes, higher left ventricle mass, and raised native T1 and T2. A total of 78 patients recently recovered from COVID-19 (78%) had abnormal CMR findings, including raised myocardial native T1 (n = 73), raised myocardial native T2 (n = 60), myocardial late gadolinium enhancement (n = 32), and pericardial enhancement (n = 22). There was a small but significant difference between patients who recovered at home vs in the hospital for native T1 mapping (median [IQR], 1122 [1113-1132] ms vs 1143 [1131-1156] ms; P = .02) but not for native T2 mapping or hsTnT levels. None of these measures were correlated with time from COVID-19 diagnosis (native T1: r = 0.07; P = .47; native T2: r = 0.14; P = .15; hsTnT: r = −0.07; P = .50). High-sensitivity troponin T was significantly correlated with native T1 mapping (r = 0.35; P < .001) and native T2 mapping (r = 0.22; P = .03). Endomyocardial biopsy in patients with severe findings revealed active lymphocytic inflammation. Native T1 and T2 were the measures with the best discriminatory ability to detect COVID-19–related myocardial pathology.
 
Two years? Why? there are currently over 2000 clinical trials ongoing of both treatments and vaccines. We've seen improvements in treatment protocols in the past 4-5 months and those improvements should continue. It's looking more likely that we will have a viable vaccine maybe as early as October/November approval for emergency use with roll out to the general public after that. Yes, life sucks right now but if people would adhere to safety guidelines for another 5-6 months we will hopefully get to a place where life is near normal. The country has faced crises like this before (Great Depression, WW2) and we did a better job of pulling together.

I agree with you. I do think it would be helpful if this timeline and probability was a lot more publicized. I don't think most people have any idea what the chances are of having a vaccine available later this year. Then, I think it would also be helpful to set a milestone such as, if we get the vaccine and are able to vaccinate X% of essential workers / vulnerable, then everyone can do X again.

Right now, one of the frustrations for many, which I think is leading to less precautions being taken, is that there is no described end game. If people were told, "we should have enough vaccine doses given by December 15 so you can most likely have a holiday season with your family and friends; now we need everyone to come together just for a few months until then," that would be a lot better than the current message, which is that this is likely to last a long time.
 
Two years? Why? there are currently over 2000 clinical trials ongoing of both treatments and vaccines. We've seen improvements in treatment protocols in the past 4-5 months and those improvements should continue. It's looking more likely that we will have a viable vaccine maybe as early as October/November approval for emergency use with roll out to the general public after that. Yes, life sucks right now but if people would adhere to safety guidelines for another 5-6 months we will hopefully get to a place where life is near normal. The country has faced crises like this before (Great Depression, WW2) and we did a better job of pulling together.


Not fast rushed like this is.
 
A lot of retail stores have already cancelled being open on Thanksgiving and early Black Friday to help stop the spread. Good luck with a vaccine by the end of the year.
 
maybe the virus is going to virus, no matter what we do, Knightfans gloomy post would make you think we have to get to zero cases. There are spikes all around the world.....and this is happening in countries who have taken great precaution. Guess what, its not going away, people are either going to have to shelter in place for 2 years or try and live their life. Its your choice

and I think the 700 person party held by Newark residents in Jackson can put to rest the notion of ITS THE RED STATES FAULT THAT ALL THIS IS HAPPENING..ITS THEIR GOVERNORS..WAAAAH.

No..its the virus and its going to do what it wants.
I've been saying since the first 14 day shelter in place order, that really did nothing, that at some point we will have to face the music. The focus has been flawed from day one. We are trying to prevent everyone from getting it instead focusing on those at most risk which is much more manageable and less destructive to the economy.
 
https://rutgers.forums.rivals.com/t...entions-and-more.191275/page-214#post-4620406

Important news should be available this week on the now completed randomized, controlled clinical trial (RCT, the gold standard of clinical science) with Roche's tocilizumab, an IL-6 inhibitor aimed at addressing the overreactive inflammatory response often called the cytokine storm, which is responsible for many COVID deaths, especially in the elderly, whose immune systems often don't work as well as those of younger people. Crossing fingers, as this could be a major step forward if it confirms the very promising mortality reduction results seen in earlier, small-scale observational studies (generally RCTs are required for "proof" of efficacy). More in the link below and some history in the post linked above.

https://www.dailymail.co.uk/health/...-treatment-halt-immune-storm-coronavirus.html

Almost forgot about this. Aren’t they already using this in some countries like India? I feel like I’ve seen articles over the last month or so with anecdotal evidence that this works, and didn’t understand why it’s not being used here. Hopefully the results from this trial changes that.

I know hospitals already use many different anti-inflammatory medicines, but hopefully this one would move the needle more. Maybe they are already using this???
 
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I've been saying since the first 14 day shelter in place order, that really did nothing, that at some point we will have to face the music. The focus has been flawed from day one. We are trying to prevent everyone from getting it instead focusing on those at most risk which is much more manageable and less destructive to the economy.

So how's your plan protect the most vulnerable while freeing everyone else?
 
To be fair, there has likely never been such a global effort to conquer a comparable disease before.
AIDS? And still no vaccine but cure is much more substantial. I think we are headed the same way with this. Each vaccine will have flaws but treatment already has shown dramitic improvement from day 1
 
I found out something last week, to be able to access my company's site, I must have a fever of 100.4 or lower.

Growing up 100 was the benchmark to staying home from school, I haven't had a fever in ages so I forget what 100 feels like (or I've hit it and didn't just realize it), I'm just surprised its set at 100.4.
Damn you were lucky my father sent me to high school with a 102 temp... turns out I had walking pneumonia and was dangerously close to hospitalization .After antibiotics and 10 days off made it through . Mom was already in hospital recovering from major surgery so I understood why my father didn’t want me to stay home . Later I would always teased him about it. God I wish he was still here.
 
So how's your plan protect the most vulnerable while freeing everyone else?
Seperation, as we all were anyway. Removing them from nursing homes to larger empty spaces which these days isn't hard to find. People with medical conditions banned from leaving their homes but being provided a lot of free services(food delivery, internet etc) and medical aid when needed. The rest of us should treat it like any other virus.
 
Seperation, as we all were anyway. Removing them from nursing homes to larger empty spaces which these days isn't hard to find. People with medical conditions banned from leaving their homes but being provided a lot of free services(food delivery, internet etc) and medical aid when needed. The rest of us should treat it like any other virus.

So warehousing seniors away from nursing homes in empty buildings? To be taken care of by whom? Caregivers now free to move about in public as if there isn't a pandemic going on?

Then giving free services to the medically vulnerable (possibly a majority of the population) ...also administered by people who are now moving around like there isn't a pandemic?

That's a better idea?
 
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Seperation, as we all were anyway. Removing them from nursing homes to larger empty spaces which these days isn't hard to find. People with medical conditions banned from leaving their homes but being provided a lot of free services(food delivery, internet etc) and medical aid when needed. The rest of us should treat it like any other virus.

Abandoned factories would be a great place to store the elderly and those in nursing homes.....lol. Every community has at least 1 or 2.....lol
 
Abandoned factories would be a great place to store the elderly and those in nursing homes.....lol. Every community has at least 1 or 2.....lol
So warehousing seniors away from nursing homes in empty buildings? To be taken care of by whom? Caregivers now free to move about in public as if there isn't a pandemic going on?

Then giving free services to the medically vulnerable (possibly a majority of the population) ...also administered by people who are now moving around like there isn't a pandemic?

That's a better idea?
FL opened-up shuttered hospital/LTC facilities to be used for covid- infected LTC patients.
Because patients must test negative twice before being sent back to nursing homes, the new COVID-only facility will serve people who no longer require hospital-level care but are still COVID-positive. In addition, long-term care facilities can transfer COVID-positive residents who need more clinical monitoring and appropriate isolation to safely recover.
https://www.miamiherald.com/news/coronavirus/article243924337.html
 
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So warehousing seniors away from nursing homes in empty buildings? To be taken care of by whom? Caregivers now free to move about in public as if there isn't a pandemic going on?

Then giving free services to the medically vulnerable (possibly a majority of the population) ...also administered by people who are now moving around like there isn't a pandemic?

That's a better idea?
Warehousing? First off had did it go with NY, NJ and PA under the current plan? Please recognize that was a complete failure and almost criminal. If you think the was the best we could you really weren't looking for an answer you were looking for arguement. If you agree that it was an absolute failure than I will explain more.
 
It is the virus, but it's going to do what we let it do. The choice is ours, collectively. Many countries have controlled it to very low levels; many have not and we've done worse than most. The spikes in other countries with low cases have been largely contained, but require vigilance to do so. And the other part isn't worth arguing with you over, since you only see things in black and white and shout about them to boot.

Also, if you've been paying attention, many experts believe we'll have a near cure soon, with engineered antibodies, which we'll know about by September, and vaccines by the end of the year, so hopefully, we're only talking 3-6 months before things are much better on a treatment/prevention front. No guarantees on that, since this is a novel virus, but I have pretty high confidence in this, as do many others in the field.


oh i have no doubt this will go away after the election if someone wins
 
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