Wow that would really be something special. Says 11/12 patients had at least one major risk factor and still improved significantly. That’s great news.
COVID-19 Pandemic: Transmissions, Deaths, Treatments, Vaccines, Interventions and More...
- Thread starter RU848789
- Start date
- Status
Even better news. Cytodyn and it’s drug Leronlimab finished enrolling it’s 75 person trial for mild to moderate (actually 85-90) on June 11. Their severe / critical Phase 3 blinded trial for Covid is up to 71 out of 390 enrolled . The CEO said today that the mild to moderate will take 14 days to complete and the severe trial will allow for interim results for 51 patients enrolled by June 1 to be released in 28 days. It will be interim and not complete trial but results could be over whelming . The key news is by the end of June both the mild/ moderate complete trial and the severe/ critical Interim results14days, ) for Covid, will be unblinded and given to the FDA for approval. In less than 15 days , we will know if Leronlimab becomes the treatment and standard of care for Covid 19. Even when a vaccine comes along, which has its own problems, people will opt for treatment instead of a vaccine. This news will help calm the discussion of the spike in cases nationally as well as in the fall. A real viable treatment is very very close.
It does appear clear that monoclonal antibodies will work in treating Covid. This was only 12 patients so they are not as far along as Leronlimab which will have results to the FDA for its mild/ moderate trial and interim results on its severe/ critical Covid trial by the end of June . Leronlimab is a monoclonal antibody that appears in EIND use , to do things no other drug does. It also potentially can treat multiple diseases, as it is going to finish 10-12 Phase 2 trials on triple metastic breast cancer, NASH, MS, multiple cancers, pancreatic and lung cancers, Altzeimers, autoimmune diseases, to name a few. It was already in Phase 3 for approval as treatment for AIDS when it was used on Covid. By the end of June we will know if this drug will be the primary treatment for Covid.
SIAP (been away today), but the FDA revoked its HCQ/CQ Emergency Use Authorization today, so we finally can close this chapter and move on to treatments that might work for hospitalized patients. What a waste. Here's the FDA source document on this and an excerpt from the FDA report.
https://www.fda.gov/media/138945/download
Based on its review, the Agency has determined the following:
• The suggested dosing regimens for CQ and HCQ as detailed in the Fact Sheets are unlikely to produce an antiviral effect.
• Earlier reports of decreased viral shedding with HCQ or CQ treatment have not been consistently replicated and recent data from a randomized controlled trial assessing probability of negative conversion showed no difference between HCQ and standard of care alone.
• Current U.S. treatment guidelines do not recommend the use of HCQ or CQ in hospitalized patients with COVID-19 outside of a clinical trial, and the NIH guidelines now recommend against such use outside of a clinical trial.
• Recent data from a large randomized controlled trial showed no evidence of benefit for mortality or other outcomes such as hospital length of stay or need for mechanical ventilation of HCQ treatment in hospitalized patients with COVID-19.
Therefore, based on the totality of scientific evidence available, it is no longer reasonable to believe that CQ and HCQ may be effective in treating COVID-19 for the authorized uses detailed in EUA 039.
not sure what thread to post this in but this is sick.....keep doing this to people and children and people's mental states are going to break down.
Justify tens of thousands protesting in Brooklyn with the De Blasio but the same guy orders playgrounds to have bars put on them
this isnt a political post, its a human issue.
Justify tens of thousands protesting in Brooklyn with the De Blasio but the same guy orders playgrounds to have bars put on them
this isnt a political post, its a human issue.
I fully suspect there is a lag to that chart as they take time to allocate new admissions to the specific date.Wait...what's the bad info here?
As you can see, if you break down the new admissions by date of admission, as this chart does, the numbers are actually near zero over the past week. There was only one new admission on Wednesday, the last day of reporting.
Otherwise how are cases, ICU beds and Vent use up?
This lag is exactly what we see on Florida's dash board in terms of death.
Maybe I'm wrong but the #'s don't add up for no new admissions.
well it probably is because it is about coronavirus and health..thats the thing..its very appropriate I think, if you are going to talk about lockdowns and deaths and opening too soon and 2nd waves and then not even address one bit all the deaths and mental issues from not opening then this is just a one sided thread for people to post doom and gloom and keep everyone in lockdown as long as possible. Its very relevant.
Certainly promising news, but let's remember it's 12 patients and not randomized or controlled, so we're going to need a lot more data on this. You can tell from the paper, linked below, that the authors are at least being circumspect with the data, not claiming too much (since most patients do get better, even hospitalized ones; these were not patients on ventilators), which is the right position for this kind of trial. Hell yeah, let's do some larger, randomized/controlled trials and let's see what it can do (a phase III trial is underway with resuts expected in September).
Lenzilumab looks to prevent the over-inflammation response of the immune system ("the cytokine storm"), which tocilizumab also does; they just do it at different points in the cascade, with lenzilumab targeting GM-CSF, as per below, and toculizumab targeting the inflammatory protein, Interleukin-6. Both are monoclonal antibody drugs with toculizumab already approved to treat rheumatoid arthritis, while lenzilumab has not been approved for any indications yet (it's under development for leukemia and didn't seem to work so well for RA).
That's about the limit of my understanding, so it's time to call in @UMRU lol...
Background: In COVID-19, high levels of granulocyte macrophage-colony stimulating factor (GM-CSF) and inflammatory myeloid cells correlate with disease severity, cytokine storm, and respiratory failure. With this rationale, we used lenzilumab, an anti-human GM-CSF monoclonal antibody, to treat patients with severe and critical COVID-19 pneumonia.
Conclusions: In high-risk COVID-19 patients with severe and critical pneumonia, GM-CSF neutralization with lenzilumab was safe and associated with improved clinical outcomes, oxygen requirement, and cytokine storm.
https://www.medrxiv.org/content/10.1101/2020.06.08.20125369v2
Show us some data on increased deaths from people stay at home orders. It certainly sucks and has probably impacted mental health some, but I've heard of no spike in suicides and people certainly aren't starving to death, plus emergency surgeries never stopped, so not sure what you're referring to.
how about from my own personal experience, my mothers death was hastened but the hospital not allowing us in to be her advocate.....not for coronavirus but have read about many case with coronavirus where the hospital or nursing home was criminal in neglect and not keeping the patients family informed. So that is one thing
you actually think that living in a society for a year where kids cannot go to a playground is okay, that you wear masks everywhere you go is sustainable..good luck. You think that somewhere down the line, the crap isnt going to hit the fan with whats going on? people have to live, this virus is going nowhere, people will die, alot of them, its likely there isnt a vaccine, I have a friend who works in the pharmaceutical industry who is very pessimistic on a vaccine in a year...and he is as liberal as they come, even he has come to the conclusion, we have to get back to living.
you actually think that living in a society for a year where kids cannot go to a playground is okay, that you wear masks everywhere you go is sustainable..good luck. You think that somewhere down the line, the crap isnt going to hit the fan with whats going on? people have to live, this virus is going nowhere, people will die, alot of them, its likely there isnt a vaccine, I have a friend who works in the pharmaceutical industry who is very pessimistic on a vaccine in a year...and he is as liberal as they come, even he has come to the conclusion, we have to get back to living.
But it does look like there are multiple treatments on the near horizon which will limit deaths as well as hospital stay.
Fine, but let's keep it about mental health.
I think some overstate it, but I do think there is an element here which we need to consider.
There were also probably less deaths as a result of accidents with people staying home
well you need to address the fact that we are bolting these playgrounds while 50K protest daily....this is just a stunning disconnect that is going on in blue cities.
Look, we know you like to pimp the stock, but leronlimab is very unlikely to be a cure for COVID - would be great if it is, but it wasn't "built" for COVID-19, as it's a CCR-5 (chemokine receptor) antagonist aimed at HIV and/or cancer (or anything else they can show it works in), which makes it a longshot to do more than moderately help like most of the rest of the existing drugs being repurposed for COVID.
Don't get me wrong, having drugs that can reduce time to recovery and/or mortality rates is way better than nothing, but in the opinions of most experts, the only thing likely to become a cure is the engineered antibody cocktails just entering clinical trials now, as these are the ones that have antibodies made to prevent virus infection or at least virus replication inside the body by directly affecting the virus's path to infection/replication (usually via the spike protein).
Closing playgrounds, especially in suburban towns, is completely asinine. Easy to manage and be safe.
I agree the disconnect is very obvious, I thought the message of covid should have been prevalent from our leaders during the protests, and conversely keeping kids out of playgrounds seems heavy handed even before the protests and even more so afterwards.
So we agree on this, but do I think we need to go further in ripping DeBlasio down for it? Not in this thread. Go start another one for that.
well i just point him out to show the hypocrisy..its why people in the middle america are saying pandemic was over 19 days ago when the protesters began so if they are saying screw precautions they are just taking their signals from what they observe
Middle america can be a bit more sophisticated then coming to that conclusion so quickly, but again, not for this thread.
You can’t stop people from protesting, pandemic or not.
I hope they protest until the moon is in the seventh house and Jupiter aligns with Mars then peace will guide the planets and love will steer the stars.
are you judging them like you judged the lake of the ozarks or nyc hipsters getting wasted in St Marks Place
how is not when posters here routinely slam De Santis, Ducey and other red state governors and Numbers is one of those posters
Didn’t judge any of them. But protesting is different than Chad getting wasted.
Where were all the anti protest people when there were protests to open the country?
apply the same standards, no one is more important, no cause, no life, just because something thinks its a seminal moment
Protesting murder of George Floyd was one thing ... just as dangerous as a rally... as long as MSM controls the narrative well we’ll see... 1 million ticket requests for a Jacksonville Florida Concert ... the group Trump is coming on tour.
political protest good, Trump rally bad...thats why you see the increased coronavirus hysteria on the tv the past few days
one ( protest) is an effort to better the nation.
The other (rally) is in someone's self interest .
Once states started opening up coronavirus started rising again.
So if you want to complain about protesting increasing the number infected, go on and I'll agree.
But that will be just a whine if you don't include states opening up causing rate of infections to rise.
Also if you want to be fair, admit Trump's rallies have a good chance of causing more COVID-19 cases
But then you might think any talk about infections rising is just a case of hysteria and there's nothing to worry about.
Many feel that way, some have found out their wrong the hard way , while others just went about their business without being harmed.
The object, in my mind, is making sure as little as possible wind up harmed.
So what's considered hysteria to some is what others consider needed info.
Last edited:
wait so people burying their loved ones dont matter, people losing their business dont matter
wow that is some selective bullcrap on your part
its great we have people like you to decide and determine what should be important in life
Someone started a separate thread about how DeSanits will not allow NJ, NY and Conn residents to Disney. This would have made sense a couple months ago, but it's a laughable move now.
No one discussed the topic here that I saw, and rightfully so.
Just to add my .02, bettering the nation is a subjective call. Different people feel differently as to which is more important.
Unfortunately the virus doesnt care
this is a coronavirus thread and politics has been woven in from day 1, you cannot escape it at this point as its become almost majority political at this pointt
But you can keep a consistent message.
If Covid is disease worthy of shutting the country down for a couple months, then you can sternly express that protestors need to stay smart. Even if it accomplishes nothing amongst those protestors. As Bac notes, others, especially those who are skeptical of the virus, or feel the shutdowns are oppressive, see these Governors drop the covid messaging when it's people out there destroying stores and looting, and say wtf?
From leadership messaging is very important. We certainly criticize Trump for his messaging regarding masks, and I do think certain democratic politicians deserve it regarding the protests as well.
hat will be just a whine if you don't include states opening up causing rate of infexctions to rise
I stated : "So if you want to complain about protesting increasing the number infected, go on and I'll agree."
Shame you feel the need to make a point with a lie and that's what leaving out a vital part of my message made your reply.
Businesses closing and people dying do matter.
So I guess you feel the protesting is wrong and against Trump having political rallies because both are unsafe right now.
Not selective BS on my part, the bullcrap was you just taking a part of my message to make a point that made my message look different than it really was.
I stated : "So if you want to complain about protesting increasing the number infected, go on and I'll agree."
Shame you feel the need to make a point with a lie and that's what leaving out a vital part of my message made your reply.
Businesses closing and people dying do matter.
So I guess you feel the protesting is wrong and against Trump having political rallies because both are unsafe right now.
It is when you bring up DeBlasio and we go back and forth on it, but it hasn't been otherwise, the Leronlimab discussion above for instance.
i want a similar standard, im for opening...so if we see mayors and governors marching and saying go out and protest but in the meantime locking everyone else down and belitting the earlier stay at home protesters then its just hypocrisy, these so called leaders limit funerals and wakes yet they encourage thousands to show up at one persons memorial...yeah for the greater good of the nation, spare me crap like that
- Status
Similar threads
