Numbers slammed Ducey just this morning, yet his thread, he continues to take shots when he wants, why only him...just askin
COVID-19 Pandemic: Transmissions, Deaths, Treatments, Vaccines, Interventions and More...
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Numbers slammed Ducey just this morning, yet his thread, he continues to take shots when he wants, why only him...just askin
Yes the virus doesn't care. So you can't be selective. People can protest and riot without consequences but I can't get a haircut and most of those businesses will fail. Changing all lives matter. We don't arrest protesters or people that riot but Philly has started giving out parking tickets. Stores that were destroyed, most will never return. Change must come in all forms fairly.
I have not seen statistics but a friend of mine from RU committed suicide a month ago, her parents said she was struggling living alone and was too afraid to fly back to the east coast at the height of the outbreak.
I’m also heading to Georgia this week to stay with a family member who is living on their own and struggling severely with depression that has been significantly amplified by the outbreak.
So it’s definitely happening and likely to a worse degree in cities where you can’t just put a lawn chair in your backyard and enjoy a beer. Most apartment complexes have closed off all rec areas.
As far back as April there were indications that mental health was taking a beating from the lock downs and such:
https://www.washingtonpost.com/health/2020/05/04/mental-health-coronavirus/
https://www.washingtonpost.com/heal...5e6744-74ee-11ea-85cb-8670579b863d_story.html
Maybe it's because #'s posts huge azz posts filled with tons of info that I can't even get through thus I typically breeze by them, but you post a video that is plain as day and not much else.
Just sayin.
I'm sorry to hear that.
This situation is definitely taking a toll on mental health. I know a few people really spiraling downhill. I also know some who are drinking way too much. People have financial issues, loneliness, anxiety etc. I see myself some days really having to push through. I worry about my parent's health. I have my mom calling upset because she misses us and then I feel bad. (My dad is driving her bonkers and she said he's losing his mind home. The garage now looks like a Home Depot Lol) I can't imagine being all alone. Some people are though. Work may be the most human interaction some people get. I feel more positive now that places are opening because this groundhog day replay is just bullsheet. I've hiked, walked, baked, cooked, cleaned and organized every thing possible. I even regrouted(?) my 1/2 bath tile floor after watching 13 videos on YouTube. I'm thankful in the end for my health but I'm done!
https://www.nj.com/coronavirus/2020...html?outputType=amp&__twitter_impression=true
This story has a lot of data on the current mental health crisis
This story has a lot of data on the current mental health crisis
thanks for posting, the media really seems to be ignoring these stories, the everyday person, how are they surviviing, its as if the wrong stories of coronavirus are told, its all hysteria, deaths, what Trump tweets and the human stories are forgotten.
everything that people go through in their normal lives are now magnified, it may seem insignificant to outsiders but for that person its their reality and it can spiral downward fast. Then you add in the news which is nothing but negativity and violence, talk about second waves, turn on the news and see looting and things being burned and lectures on how you should act, where you should go, how you should think.
We are only 3 months into this..it can easily get worse if NORMAL does not come back
Sorry to hear that JB. That sucks. Good for you for visiting that family member.
So as I understood, covid admissions most likey result in long term hospitalization with significant ICU care. This costs are substantial. Regardless of coverage (Medicare or private) those costs will be passed to all of us. So those with the "I will be fine, most people will be fine" attitude should consider the cost they will bear for those they may infect. Just another angle that seems to have not been discussed.
Until we see it don’t keep saying “ we’re very , very close” ...close only counts in horseshoes... We have a long way to go...
+1 How about it @bac2therac , you actually have to support broad claims with actual evidence once in a while.
Fwiw, I agree with you that hosting protests for weeks on end during lockdown is ridiculous. I think it was a pragmatic, lesser of two evils decision to try to prevent things spiraling, but still looks ridiculous
Why worry everything is going to be free ...well for certain parts of our society it appears...
You need to move to CHOP...a great place ... in your case make sure you have $ 10 for the BLM movement demands of all those visiting.
Just look at this site as an example of those who drink in excess daily, nitely and are proud of it...eventually it catches up to them while destroying families and lives in an alcoholic wasteland.
Don’t worry about tomorrow... tomorrow may never come... you may die from Covid 19 so why worry about paying any bills .... I just read the NJ.com article about 250k who may be left out of receiving their stimulus check....many never filed income tax in 2018-2019... don’t receive social security benefits.. perhaps not here legally... so why should we worry? Life is too short ...isn’t that what many say and should believe.
You are becoming a pro at this @RU848789
The Docs are now good at predicting who is going to crash. So getting 11 of 12 who are going downhill out of the hospital in 5 days is pretty amazing.
The one downside I see is that they used 1.8 grams of antibody protein per person. If I did the math right, that means they need about 2 pounds of protein to treat 500 people. That is a lot.
What is interesting about this is that drugs like this are that many all offshoots of trying to stop cytokine storms that come from T cell therapy (CAR-T) for curing cancer. Now they are turning out to be useful in an entirely different setting.
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Another one to watch for is called Anakinra (or Kineret). It is the interleukin 1 receptor agonist protein. IL-1 starts nearly all of these cytokine cascades.
Are there any antivirals in trial yet that can be taken (i.e. something like tamiflu)???
You do realize that illegal immigrants don't have a taxpayer ID, so aren't able to get medicaid, social security, or this CARES act benefit, right?
As for the others who may miss out, I feel bad for them. As mentioned in the article, they are generally un the most vulnerable population. There are plenty of folks who don't need the help, but aren't going to turn down the $1200 checks/ debit cards for their household. Those are the people you should be mad at.
We're going to be in a cycle of tons of stimulus for quite a while. Powell was saying 2 years or something like that for this round of QE...
Huh? People have been excoriating Murphy in this thread over and over and I make one post on Ducey, who clearly is a friggin' idiot who continues to downplay the virus, and somehow I'm the only one taking shots? My informational to political ratio in my posts is pretty damn high and yours is about zero. You really should think a little bit before you post.
Your missing my point. Those costs will be recouped. You our I may have coverage but those spreads will be applied to everyone.
You fool Murphy is a democrat so that’s okay he’s not one of Bac’s chosen people
Yeah but it’s via IV. Need a medicine that can be taken outside of hospitals.
We agree on much of this. I've said multiple times that I would like to see more on the virus and how best to prevent/fight it, including a lot more on transmission and treatments and less about Trump and politics in the media, which has always been my general goal with this thread. I'd also like to see more positive stories of people surviving and thriving - it doesn't have to be mostly negative. It's why I don't watch much cable news, getting much more of my science/medical news from a few key internet sources and maybe checking BBC or the Times once a day for regular news.
However, since there are political decisions that have had huge impact on the progression of the virus (and will be more), it's not realistic to have zero political discussion, but personally I try to keep a high information to political ratio in my posts. But since the demise of the CE board, many of the CE regulars now post here and much of it is not informational, which detracts from the value of the thread. In my opinion. Personally, I'd much prefer if you and some others just started separate threads about ancillary coronavirus issues, like closing parks or anything to do with protests or mind control or whatever, but I agree that mental health impacts are fair to talk about, as this has been very tough on very many, including people near and dear to me.
The new antiviral that Merck bought from Ridgeback is an antiviral with better in-vitro and animal activity against the virus than remdesivir and it's orally bioavailable (pill), which is why many are excited about it. Trials are ongoing. But like most of the antivirals, it'll likely only be moderately effective - we need the far more targeted antibody therapies for that. Next post...
Thanks! Some chatter that they "stacked the deck" with cases more likely to get better, but that could be BS. Regardless, the results on12 patients is promising, but not nearly enough. And wow, 1.8 g is a horse pill - these monoclonal antibodies are pretty expensive to make so that's not going to be very cost effective. Also, yes that's about 0.9kg/2.0 pounds for 500 people, which is 90,000 kg for 5MM people, which if it's that good would be a near impossible task - making 90,000 kg of a synthetic small molecule is doable in a major factory in a year, but the mab processes are almost all way less productive than the chemical processes. Yikes.
Numbers , you call me a pimp and you fail to understand everything the drug does and that Covid 19 is a Rantes disease identified by Dr. Bruce Paterson , whose paper is being peer reviewed for the NEJM presently , hopefully published in a couple of weeks. Listen I enjoy your posts but tone down your pimp comments and get educated on Leronlimab , so I do not have to call you ignorant because you didn’t even try to find out everything about the drug and how this little company has a chance to have a break through over BP. Listen to the doctors.
Nobody on this site bitches as much as you... even the guy who wouldn't leave his house for 4 months said that your corona drama is over the top. You were crying a few days ago because you were in disbelief that people went out to eat. I guess you have a reason to worried because according to you 1 in every 20 people who get this virus will die from it.
No, you simpleton. When you see it , it is already approved and the FDA or CDC declares it as the standard of care. When the trials are less than a month from completion, maybe 2 weeks away, from being submitted to the FDA , they are close or very close. I am just trying to give a hopeful update on treatments which is one of the primary reasons I and many others came to his thread. Not some political crap. We do not have a long way to go for effective, safe treatments.
More on the Regeneron engineered antibody approach, as they published two fascinating papers in Science on this, today, linked below. After producing a few hundred antibodies from their humanized mouse model, they did studies on activity of these against a pseudo SARS-CoV-2 virus, narrowing it down to about 9 candidates for further studies that they tested against this pseudovirus and the authentic virus, finally settling on a "cocktail" of two antibodies that show very high neutralizing activity against the virus. Note that these antibodies are indistinguishable from human antibodies collected from plasma from recovered COVID patients and they can scale up the process to make large amounts of these antibodies in large cell culture bioreactors.
The reason for a mixture of antibodies is that the two intercept viral entry into human cells by binding tightly to two different parts of the virus's RBD (receptor binding domain) - the big "spike" protein you see in all the pictures that is key for the virus gaining entry via the ACE2 receptor on lung and endothelial cells. Regeneron showed that a combo of two antibodies ensured that any mutant variants they saw in the lab (with the pseudovirus) would be stopped by at least one of the antibodies, whereas a single antibody treatment might not be able to stop a mutated form in a person from evading that antibody, as it would require two simultaneous viral mutations to defeat both antibodies. This lesson was learned in the HIV field, where eventually cocktails of 2-3 antiviral drugs were required to defeat the virus. Not to beat a dead horse, but Regeneron is my pick to have the best engineered antibody drug, mostly because of their impressive success against Ebola with the same approach a couple of years ago.
https://science.sciencemag.org/cont...c0123f628dd52f86ce70468b&keytype2=tf_ipsecsha
Abstract
Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments for Ebola – one from genetically-humanized mice, and the other from a human survivor. Here, we describe parallel efforts using both humanized mice and convalescent patients to generate antibodies against the SARS-CoV-2 spike protein, yielding a large collection of fully-human antibodies that were characterized for binding, neutralization and three dimensional structure. Based on these criteria, we selected pairs of highly-potent individual antibodies that simultaneously bind the receptor-binding domain of the spike protein, providing ideal partners for a therapeutic antibody cocktail that aims to decrease the potential for virus escape mutants that might arise in response to selective pressure from a single antibody treatment.
https://science.sciencemag.org/content/early/2020/06/15/science.abd0831
Abstract
Antibodies targeting the spike protein of SARS-CoV-2 present a promising approach to combat the COVID19 pandemic; however, concerns remain that mutations can yield antibody resistance. We investigate the development of resistance against four antibodies to the spike protein that potently neutralize SARS-CoV-2, individually as well as when combined into cocktails. These antibodies remain effective against spike variants that have arisen in the human population. However, novel spike mutants rapidly appeared following in vitro passaging in the presence of individual antibodies, resulting in loss of neutralization; such escape also occurred with combinations of antibodies binding diverse but overlapping regions of the spike protein. Importantly, escape mutants were not generated following treatment with a non-competing antibody cocktail.
Ok, I won't use the word pimp any more, but the fact still remains that leronlimab is an mAb targeted at a human protein receptor in a patient's body, and like most other mAbs that do that, especially those modulating the immune response system, there is always both significant risk and potential lack of efficacy. This drug is not targeting the virus, per se, which is why the engineered antibodies are far more likely to be efficaceous and safe, since they should only be targeting the virus. Some of the engineered antibodies are indistinguishable from actual human antibodies. To expect more than modest success with any of these repurposed drugs is unwarranted.
Most people are skeptical , doubting and have been told the very opposite by scientists and medical experts. You do realize that the number of those needing treatments will far outweigh any supplies not for weeks but months. We shall see what transpires.
LOL obsessed? You follow me around like a dog. And you try to derail all the threads I start. Sad.
https://www.nationalreview.com/news...sitive-cases-if-theyve-attended-blm-protests/
From a health prospective (never mind the insane politics of this) but does this not undermine the idea of contract tracing and risk more and more people becoming ill. Not to mention what this does to government communications and people following direction.
From a health prospective (never mind the insane politics of this) but does this not undermine the idea of contract tracing and risk more and more people becoming ill. Not to mention what this does to government communications and people following direction.
That's dumb IMO. It's like those comments yesterday from Scott Gottlieb with regards to contact tracing....it's not that you necessarily find every single infected person but you do want to identify the activities that led to clusters/outbreaks.
Just saw a story similar to ones we've seen in the past with regards to churches. WV has seen some clusters develop in five churches. So you want to know the activities which led to the outbreak and try to take appropriate mitigation steps.
https://news.yahoo.com/west-virginia-sees-coronavirus-outbreaks-in-churches-200854506.html
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