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COVID-19 Pandemic: Transmissions, Deaths, Treatments, Vaccines, Interventions and More...

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You’re ok Greg ... what is good even in fears and sadness is to find some small hints of humor and mutual respect ... that is what we all must do... the hate needs to stop just as this virus.
 
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Where have you been? Good to see you back in the fold hopefully--there's a ton of certain media talking points being regurgitated around these supposedly CE-free threads. Need more informed and commonsense folks involved.:USA: :America: :AmericanFlag::USA: :America: :AmericanFlag::USA: :America: :AmericanFlag::USA: :America: :AmericanFlag:

This is not the CE board dude. Stop treating like it is.
 
Unfortunately NJ is poised for more trouble from Covid19
I would not be surprised - more and more we're seeing people no longer social distancing at stores, at times walking around with their mask just covering their mouth, not their nose, etc. The other day I was next in line for a register, woman got behind me within 3 feet, I turned around and stared her down until she stepped back. C'mon, this has been out there for months, what's your problem. I think we're headed for a mild bounceback in Jersey because once again people are only thinking of themselves.
 
Did So Korea send their elderly COVID-infected citizens into nursing homes? Asking for a friend.
I don't know the answer to this but how prevalent are such things like nursing homes in Asia anyway. Many households are multi-generational and the elderly live with one of the children often. That's been the case in my household here and I grew up here. Your children are your social security etc...
 
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Looks like some additional big, positive antibody news in a paper that came out yesterday (preprint, so not peer-reviewed yet, but looks solid) confirming and extending Dr. Krammer's work at Mt. Sinai, posted above. A Chinese study on 349 of the earliest patients from Wuhan shows ~6 months of generally durable antibody response in the "vast majority" of convalescent patients (who recovered from COVID infections). This is very good news for recovered patients retaining immunity for 6 months or more and for any vaccines able to raise neutralizing antibody responses (which we have seen).

https://www.medrxiv.org/content/10.1101/2020.07.21.20159178v1.full.pdf

Abstract: Long-term antibody responses and neutralizing activities following SARS-CoV-2 infections have not yet been elucidated. We quantified immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) of the spike (S) or the nucleocapsid (N) protein, and neutralizing antibodies during a period of six months following COVID-19 disease onset in 349 symptomatic COVID-19 patients, which were among the first world-wide being infected. The positivity rate and magnitude of IgM-S and IgG-N responses increased rapidly. High levels of IgMS/N and IgG-S/N at 2-3 weeks after disease onset were associated with virus control and IgG-S titers correlated closely with the capacity to neutralize SARS-CoV-2. While specific IgM-S/N became undetectable 12 weeks after disease onset in most patients, IgG-S/N titers showed an intermediate contraction phase, but stabilized at relatively high levels over the six months observation period. At late time points the positivity rates for binding and neutralizing SARS-CoV-2-specific antibodies was still over 70%. Taken together, our data indicate sustained humoral immunity in recovered patients who suffer from symptomatic COVID-19, suggesting prolonged immunity.

Conclusion: In conclusion, antibodies appear to have antiviral effects in the early stages of SARS-CoV-2 infection; and the most symptomatic patients with COVID-19 remain positive for IgG-S and exhibit sufficient neutralizing activity at six months after the onset of illness. These results support the notion that naturally infected patients have the ability to combat re-infection and vaccines may be able to produce sufficient protection. Please note, that analyses which terminated their observation earlier than ours and extrapolates the long-term trend based on this contraction phase without considering or determining the consolidation phase, bear the inherent risk to come to wrong over-pessimistic conclusions concerning the durability of humoral immune responses.

There have been recent reports that seemed to indicate antibodies disappear after a few months. Were those reports overdone? Not sure if the reports actually said that, but that’s what the narrative seemed to be the last few weeks.

This study seems to indicate while antibody levels decrease, they seem to plateau to a level that still provides protection. Do you know if those levels match what we’ve seen in some of the vaccine trials? We don’t have a snapshot after 6 months, but I think we have after 2 months for most of the vaccines.
 
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South Korea actually had masks to distribute and wear. USA was busy being the World Police and General Good Neighbor and sent China our PPE. They sent us the virus in return.
No the USA sent China our pharmaceuticals, tech, manufacturing beginning 25 years ago and has nothing to do with world peace... so unless you are being sarcastic this country and it’s people are not the issue...
 
There have been recent reports that seemed to indicate antibodies disappear after a few months. Were those reports overdone? Not sure if the reports actually said that, but that’s what the narrative seemed to be the last few weeks.

This study seems to indicate while antibody levels decrease, they seem to plateau to a level that still provides protection. Do you know if those levels match what we’ve seen in some of the vaccine trials? We don’t have a snapshot after 6 months, but I think we have after 2 months for most of the vaccines.

Good question. If you dive into the links I provided or track back through the post I quoted and its links there's some discussion of that, as I shared those papers a month or so ago, but off the top of my head, the earlier studies showed significant antibody decreases over about 6 weeks after recovery from infection, but that was the end of the study, so they weren't "wrong," but they overstated what it meant, since a decrease and then a later increase is fairly common in viral responses.

This excerpt from the paper says it better than I could (especially the part I bolded) and it's not too "deep." None of this is a "guarantee" of 6+ months (or longer) of immunity for recovered patients or that vaccines will work that produced these antibodies (and T-cells; the current paper didn't analyze T-cell response, but they're likely there), but that's absolutely the way to bet now in light of this paper and Krammer's paper.

The discussion of rapidly declining humoral immune responses provoked broad media attention, raising doubts and anxiety about the feasibility of vaccine development and immunity after infection. Based on our data, it appears that the humoral immune response to SARS-CoV-2 in symptomatic COVID-19 patients is rather prototypical for viruses in having an early expansion phase followed by an intermediate contraction phase and a sustained memory phase. Analysis that terminated their observation period earlier than in our study, but extrapolated a long-term trend based on the contraction phase without considering or determining the memory/consolidation phase, bear the inherent risk to come to over-pessimistic conclusions concerning the durability of humoral immune responses after SARS-CoV-2 infection. Even primary infections inducing live-long immunity (e.g. measles infection) and very effective vaccine such as the yellow fever and rabies vaccine have a transient contraction phase in the antibody response. Although only the future will show how long protective immunity will last after natural infections or prophylactic vaccination against SARS-CoV2, our data suggests that SARS-CoV-2-specific antibody responses are quite similar to responses against many other viruses that induce immunity in humans, including the ‘common-cold’ Corona Viruses that have been shown to mediate protective immunity at for many months to years.
 
No the USA sent China our pharmaceuticals, tech, manufacturing beginning 25 years ago and has nothing to do with world peace... so unless you are being sarcastic this country and it’s people are not the issue...
Are you saying the reports of the USA sending China millions of masks before we knew the virus had spread to the shores of the USA was fake news? And that once the virus was detected here, the population had little to no PPE to slow the infection, all untrue?
 
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Good question. If you dive into the links I provided or track back through the post I quoted and its links there's some discussion of that, as I shared those papers a month or so ago, but off the top of my head, the earlier studies showed significant antibody decreases over about 6 weeks after recovery from infection, but that was the end of the study, so they weren't "wrong," but they overstated what it meant, since a decrease and then a later increase is fairly common in viral responses.

This excerpt from the paper says it better than I could (especially the part I bolded) and it's not too "deep." None of this is a "guarantee" of 6+ months (or longer) of immunity for recovered patients or that vaccines will work that produced these antibodies (and T-cells; the current paper didn't analyze T-cell response, but they're likely there), but that's absolutely the way to bet now in light of this paper and Krammer's paper.

The discussion of rapidly declining humoral immune responses provoked broad media attention, raising doubts and anxiety about the feasibility of vaccine development and immunity after infection. Based on our data, it appears that the humoral immune response to SARS-CoV-2 in symptomatic COVID-19 patients is rather prototypical for viruses in having an early expansion phase followed by an intermediate contraction phase and a sustained memory phase. Analysis that terminated their observation period earlier than in our study, but extrapolated a long-term trend based on the contraction phase without considering or determining the memory/consolidation phase, bear the inherent risk to come to over-pessimistic conclusions concerning the durability of humoral immune responses after SARS-CoV-2 infection. Even primary infections inducing live-long immunity (e.g. measles infection) and very effective vaccine such as the yellow fever and rabies vaccine have a transient contraction phase in the antibody response. Although only the future will show how long protective immunity will last after natural infections or prophylactic vaccination against SARS-CoV2, our data suggests that SARS-CoV-2-specific antibody responses are quite similar to responses against many other viruses that induce immunity in humans, including the ‘common-cold’ Corona Viruses that have been shown to mediate protective immunity at for many months to years.

Really good stuff here. Thanks.
 
Where have you been? Good to see you back in the fold hopefully--there's a ton of certain media talking points being regurgitated around these supposedly CE-free threads. Need more informed and commonsense folks involved.:USA: :America: :AmericanFlag::USA: :America: :AmericanFlag::USA: :America: :AmericanFlag::USA: :America: :AmericanFlag:
There is a small but triggered group here who is actively trying to get me banned. We know who they are. Just need to keep calling them out for their misdeeds and expose the obvious hypocrisy.
 
OK

DEATHS:

SK 297 US 90,000+

Tell me how we as a nation are doing well.
We are doing much better than many Euro countries when you look at death rates. UK and Belgium are horrific for starters. Many others worse than us.

SK has zero diversity, less rights, and no protestors spreading it at the worst time. We’d have to fundamentally change this entire country if we wanted to emulate them. Are you advocating that?
 
I would not be surprised - more and more we're seeing people no longer social distancing at stores, at times walking around with their mask just covering their mouth, not their nose, etc. The other day I was next in line for a register, woman got behind me within 3 feet, I turned around and stared her down until she stepped back. C'mon, this has been out there for months, what's your problem. I think we're headed for a mild bounceback in Jersey because once again people are only thinking of themselves.

Even with mask wearing we’ll likely see explosive growth again in the NY metro area this winter. The CDC and WHO need to stop waffling and finally admit this is an aerosolized virus. It may not be as aerosolized as smallpox, but how else does 1 person infect 500+ people within a day in manufacturing plants and prisons. If it can be spread via HVAC thats a HUGE problem that mask wearing will not solve (since masks are not worn to protect you, but to protect others. Problem is that admission would likely roundhouse the global markets again.
 
We are doing much better than many Euro countries when you look at death rates. UK and Belgium are horrific for starters. Many others worse than us.

SK has zero diversity, less rights, and no protestors spreading it at the worst time. We’d have to fundamentally change this entire country if we wanted to emulate them. Are you advocating that?
You have no idea what you're talking about yet again. In 2 months at our current rate, we'll be 2nd in the world in per capita deaths, passing all those European countries we're slightly to moderately behind ("much better" is a fantasy) and we'll be behind only Belgium - and the only reason for that is Belgium is the one country that's reporting deaths accurately (we're well undercounting vs. excess deaths). Brazil may pass both of us, though.

And you and your buddy keep talking about how "different" SK is. You mean, like well-prepared, efficient, with aligned leadership and people all working towards a common goal, executing nearly flawlessly on early aggressive testing with comprehensive tracing/isolating and nearly 100% mask wearing, all without any serious lockdowns? Yeah, I'll buy that - we have had very little of that, despite having the best pandemic playbook and being rated the country "best prepared" for a pandemic. Talk about underachieving.
 
Holy Name Hospital in Teaneck is seeing an uptick in COVID cases, much earlier than expected. Teaneck was the epicenter of cases in NJ in the spring
 
Holy Name Hospital in Teaneck is seeing an uptick in COVID cases, much earlier than expected. Teaneck was the epicenter of cases in NJ in the spring
How many do they have ?I remember a few weeks reading how they were down to none.
 
nice game you play. You say every other country that does well is not like us, and then you say no countries are like us when asked.
There is no country like us is 100% correct, it's not even debatable. A handful may be somewhat comparable, but far from apples-to-apples. List the foreign countries and their characteristics that you believe are like the U.S. Thanks.
 
This is fair. I'll concede that Fauci should have known better and expected people to photograph him at the game and that some would criticize him for not wearing a mask, even if only for the symbolism. However, in his defense, he's only been in the limelight a short time, so my guess is he simply wasn't even thinking about it, since he implied strongly that he's "safe" with his wife and very good friend - I'm guessing the three of them probably don't wear masks at all when they're together off camera, which is ok.

He also knew that the first pitch would be highly covered by the media and knew he could've not worn a mask being 6+ feet away, but for the cameras he knew the symbolism was important, so he wore the mask. And I agree completely that a minor slip-up when one thinks he's off-camera is far different from the POTUS actively mocking mask-wearers and refusing to wear a mask for months in public, both of which certainly has played a role in so many of his loyal followers feeling like wearing masks is unnecessary.


What he did was despicable. All it takes is one second from those droplets spreading. There is no time out for Covid. He should know better. Those poor souls that could be infected and die from his thoughtless malfunction God help them.
 
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Even with mask wearing we’ll likely see explosive growth again in the NY metro area this winter. The CDC and WHO need to stop waffling and finally admit this is an aerosolized virus. It may not be as aerosolized as smallpox, but how else does 1 person infect 500+ people within a day in manufacturing plants and prisons. If it can be spread via HVAC thats a HUGE problem that mask wearing will not solve (since masks are not worn to protect you, but to protect others. Problem is that admission would likely roundhouse the global markets again.

No, we won't if we have nearly universal mask wearing. Also, if it were that easily aerosolized, such that it was spread by HVAC systems, we'd have far more people infected. Several countries have shown that universal masking/distancing are nearly enough to stop transmissions.

In addition, it's just as plausible that during a day, one person infects 10 and several of them infect 5-10 more and pretty quickly one can get to 500 and there have also been the occasional superspreaders who have infected 25-50 people, almost all in large indoor gatherings involving a lot of close contact (i.e., the HVAC was not suspected); the only large outdoor spreading event I know of is the UEFA soccer match featuring Bergamo from Northern Italy, which many think seeded the huge outbreak there after many fans caught the virus there and spread it in Italy - others at soccer matches are suspected, which is a big part of why European soccer leagues have no fans at the game.
 
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