OT: NEW EVERYTHING / ANYTHING COVID-19 THREAD PART II
- Thread starter Richie O
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You think those people that check tickets at rutgers stadium gonna be able to check for vaccine cards ? Talk about out performing your pay grade
All NJ Transit workers eligible for vaccine on 3/15. Makes perfect sense and I would have had them a little earlier but we were a little confused in the early stages here in NJ. Things are opening up and hopefully all elderly will be completed by that time as well.
I’m biting my tongue really hard here on what we want to check ID’s for and what we allow to go unchecked. Lol
How about a chip inserted under your skin. My dog had one. Thankfully never had to use it.
I think the vaccines already input that chip when you get the shots. :)
Rutgers should allow Mail-In vaccine validation to the Ticketing office. As long as they are received 1 week before game day, the self confirming applicant should be good to go !! The government trusts this process for important events, so should be good for a football game... right? Since RU is using electronic ticketing now, should not be a problem. The ticket account owner can be responsible for collecting the validations from all the tickets he /she distributes and send them all in to RU ticket office.
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This P1 variant really has the insurance sector spooked. A number of firms we consult for are asking us to do claim analysis on potential exposure if this variant goes through an exponential growth phase. This was not asked of us for any of the other variants in circulation.
Looks like it's that study out of Brazil showing significant reinfection that has the gears turning. Plus if a vaccine tweak is needed it would render all of the vaccinations to date relatively useless for what they were intended for and delay vaccination another 3-6 months.
Looks like it's that study out of Brazil showing significant reinfection that has the gears turning. Plus if a vaccine tweak is needed it would render all of the vaccinations to date relatively useless for what they were intended for and delay vaccination another 3-6 months.
Well let ‘s hope not a reality. Ok so let’s allow in all of South and Central America. Brilliant educated morons.
Think they already found out that the P1 is not as bad as the SA variant. Vaccines should still work on them both, although not as well as the OG strain.
If only we had a communist government and citizens were slaves of the state. Pretty easy to "get stuff done" in those circumstances.
Not sure this was posted yet. And there is no link to the study.
news.yahoo.com
(edit) Here is the study
Obesity a driving factor in COVID-19 deaths, global report finds
The report, which described a "dramatic" correlation between countries' COVID-19 death and obesity rates, found that 90% or 2.2 million of the 2.5 million deaths from the pandemic disease so far were in countries with high levels of obesity. The study analysed the COVID-19 death figures from...
(edit) Here is the study
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www.worldobesityday.org
Apparently this guy is in a band in the UK. The Stone Roses
Here's an update on variants and vaccines. A recent paper (preprint, not peer reviewed yet, but from a very reliable source) just came out looking much more deeply into the adaptive immune responses (T-cells/B-cells) to all of the major variants in both infected/recovered patients and post-mRNA-vaccination (Pfizer/Moderna) patients, and the news is quite good as the adaptive immune response to the UK (B.1.1.7), South African (B.1.351), Brazilian (P.1), and California (CAL.20C) variants is quite strong for both types of patients. This likely means that reports that antibody responses to these variants were not nearly as robust, is likely not that important and post-vaccination immune response to these strains should likely be assumed to be similar to what is seen for the original strain.
https://www.biorxiv.org/content/10.1101/2021.02.27.433180v1.full.pdf
Derek Lowe also weighed in on this paper and had similar comments, which is reassuring, although we're 100% aligned that we're playing evolutionary Russian roulette with variants, meaning the more transmissions that occur in the world, the more likely a variant could emerge that eludes the vaccines, which is why vaccinating as fast as possible here and worldwide is so important.
Speaking of that he also weighed in on the Novavax vaccine conundrum in the US, where their phase III clinical trial is likely decelerating due to decreased transmission rates, which could delay filing for an EUA. He, like many others, believes that the robust Novavax phase III dataset from the UK and SA ought to be enough for a US EUA, especially given the preceding paragraph - we need to get transmissions down both to save lives and to reduce the probability of elusive variants and adding another vaccine, especially a refrigerator storage one, can only help in that regard.
https://blogs.sciencemag.org/pipeline/archives/2021/03/02/early-march-vaccine-thoughts
Hey @DJ Spanky - remember when I was whining about locked threads meaning the "reply" and "quote" functions were disabled, which annoyed me as I do that a lot? Figured out a workaround. Simply reply to any post in the thread, strip out the post contents, replacing it with the contents from the post in the locked thread, and then replace the "post #" in the quoted post with the post # from the locked thread post. See above.
Apparently this guy is in a band in the UK. The Stone Roses
Sorry, but who cares?
Some more details on what could look like the "afterthought" part of the Merck announcement the other day, relative to the vaccine announcements, but may end up being pretty important. The antiviral drug that Merck has licensed from Ridgeback Biotherapeutics, known as EIDD-2081, which came from the Emory Institute of Drug Development, a small company, that George Painter (famed drug discovery scientist) joined in 2013, shows some amazing activity against all kinds of viruses (including SARS-CoV-2) in vitro and in animals and is about to start phase II clinical trials.
It has shown better activity against the virus in vitro and in animals than remdesivir - both attack the same RNA polymerase enzyme in the virus, but Remdesivir blocks the enzyme so the virus can't replicate, while EIDD-2801 causes the enzyme to make replication mistakes which ead to a catastrophic mutational burden.
Whether it will work well in humans is obviously an open question, but if it does, one major advantage it has over remdesivir is that it's orally bioavailable, so it's available in tablet form, meaning it doesn't need to be dosed by IV in a hospital. One drawback is its potential mutagenicity, although with an acute (5-day dosing), potentially lifesaving application, one would think that wouldn't be a showstopper. It also looks like a relatively simple molecule to make (good chance this would've been my team's project if I hadn't retired), so if it works, I doubt availability would will be a major issue. Stay tuned.
https://cen.acs.org/pharmaceuticals..._source=LJ&utm_medium=Social&utm_campaign=CEN
https://www.ft.com/content/de7df1ee-c566-4c79-9b3e-9b7d792d424c
A paper was published today on phase I clinical trials (pharmacokinetics and safety, not efficacy) with Merck's orally bioavailable antiviral drug, molnupiravir (MK-4482). This is the molecule I've been consulting on for the past 6 months, working with my old group in the Process R&D area (in an ironic twist, the guy leading the project form the process side was in my group for 10 years, but now he's my "boss" lol, which we chuckle about). The paper is linked below and it at least appears that the drug is metabolized as expected and is pretty well tolerated. Now we just need to see efficacy, which will be coming by late March.
If effective in large scale trials, this would become the first orally available (capsule/tablet) antiviral for use in mild to moderately ill COVID patients, where there's certainly a need as remdesivir isn't particularly effective and requires an IV. Also, this could likely be co-administered with the antibody cocktails, as they have different mechanisms of action, which would likely be complementary. Derek Lowe (In the Pipeline) also blogged about this small molecule drug candidate today and he's quite upbeat on it, given how effective it has been in animal studies with COVID and other viruses, so far.
https://aac.asm.org/content/aac/early/2021/02/24/AAC.02428-20.full.pdf
https://blogs.sciencemag.org/pipeli...-last-of-the-small-molecule-coronavirus-hopes
Huge Stone Roses fan, but Ian has always been a bit of a wanker, lol, which is why they've only put out few albums over 30 years...Apparently this guy is in a band in the UK. The Stone Roses
Connecticut is lifting capacity restrictions on March 19th. Mask rules are not changing for now.
NBC tweet on Connecticut
NBC tweet on Connecticut
A
anon_ivydyf0amkzay
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They’re ALL China strains...
/HTH
For the initial outbreak in Wuhan, yes, there's no way such an enforced draconian lockdown would have ever worked here and I'm good with that. However, post-Wuhan, their use of our pandemic playbook was textbook, especially with regard to massive, rapid testing anywhere there were flare-ups (along with tracing/isolating contacts), which is what one has to do to prevent flare-ups from becoming major outbreaks. That and having a very effective communications program to effect near 100% mask wearing. Other countries, like South Korea, Taiwan and several others in that table I posted were able to be similarly efficient and have far, far fewer cases/deaths.
We all understand . We all know where it came from. We all know how many incompetents there were and still are. We know it is still political. We know eventually people are going to say Enough Is Enough. We know know the reasons it is still used as a weapon even with 3 vaccines available and millions able soon to be vaccinated . Yet the‘re still predicting doom n gloom daily . NOT HOPE but contempt for people , groups, philosophical differences.Face it people are sick of this crap.Goodnite 🤟
A friend of my daughter called and received the JNJ shot all in the same day in Jackson
It looks like things are opening up because anecdotally I have become aware of at least 10 people who were able to schedule the shot within a week
It looks like things are opening up because anecdotally I have become aware of at least 10 people who were able to schedule the shot within a week
Yep, seeing tons of friends now getting shots scheduled, which is great...
Yet my parents in their 80's, who registered on the state website as soon as they were eligible, still have received no opportunity to book appointments from the state.
I later registered them with several other sites that use their own system.
Thanks to helpful suggestions on this football message board, I was able to get them appointments at Rowan, Sewell/Deptford for later this month.
But the fact the the state has yet to contact them to make appointments, even while I keep reading here and elsewhere how people got appointments like you describe is incredible. NJ's system is a major cluster F!@$.
By comparison, I live in New Hampshire. Here you register with the state and nowhere else. All vaccination appointments are scheduled through one system. All the state-run sites as well as the CVS and Walgreens, etc are handled in the same system. My group isn't yet eligible, but my wife and her mom, who are were initially given appointments for a first shot in April. Then as the supply increased they both received calls with the opportunity to move up their appointments. They had their first shots a couple weeks ago. There was no calling multiple places, or registering with multiple websites. No opening multiple incognito browser sessions on vaccine appointment sites to try and secure better "lottery" numbers. no muss, no fuss. Yes NH has 1 million people to NJ's 8 million. But that should not prevent NJ from managing a single cohesive system that lets the 80 year old's, who are not computer savvy, secure appointments in a simple fashion.
My staff and I all had the Pfizer vaccine. We all had symptoms post 2nd shot including tired, head aches, muscle aches , chills and one person had a low grade fever. We all tested ourselves 3 weeks post vaccine for antibodies and we all have them. Life is good
As of this morning the top 5 counties by % of population receiving at least 1 vaccination
Cape May 24.3%
Morris 22.3%
Gloucester 19.0%
Monmouth 18.5%
Somerset 18.2%
Monmouth County, NJ COVID-19 Vaccine Tracker | heraldtribune.com
Cape May 24.3%
Morris 22.3%
Gloucester 19.0%
Monmouth 18.5%
Somerset 18.2%
Monmouth County, NJ COVID-19 Vaccine Tracker | heraldtribune.com
CVS just opened up another 100+ NJ locations where you can get the vaccine.
That’s not what he meant as some of my men are very young and qualify just like you did.
Can’t be as not everyone will be able to do that.
Just my opinion but the state should have had the Queen of Rutgers Football at the very front of the line😁
I think that is a fair assessment and NJ should be criticized for it
In the past week my ex, son, daughter, sister, and 3 friends all had appt's scheduled. I showed up at Brookdale CC only to find a friend in line with the same scheduled time.
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